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Claire Wyman

Claire Wyman

D-Index & Metrics

Genetics

D-Index
59
Citations
12336
World Ranking
3246
National Ranking
113

Overview

Claire Wyman is a researcher affiliated with Erasmus MC in the Netherlands, focusing primarily on the field of Biochemistry, Genetics and Molecular Biology. Their work spans several subfields including Molecular Biology, Biophysics, Oncology, Plant Science, and Structural Biology.

Their research addresses a range of topics within these fields, particularly emphasizing DNA repair mechanisms, CRISPR and genetic engineering, and related molecular processes. Key topics in their publications include:

  • CRISPR and Genetic Engineering
  • DNA Repair Mechanisms
  • Genetically Modified Organisms Research
  • Fungal and Yeast Genetics Research
  • PARP Inhibition in Cancer Therapy
  • Cell Image Analysis Techniques
  • Advanced Fluorescence Microscopy Techniques

Wyman has published multiple papers contributing to an understanding of molecular interactions in DNA repair, among other areas. Some notable recent publications include:

  • Role of BRCA2 DNA-binding and C-terminal domain in its mobility and conformation in DNA repair (2021, eLife)
  • Conformational flexibility and oligomerization of BRCA2 regions induced by RAD51 interaction (2020, Nucleic Acids Research)
  • BRCA2-HSF2BP oligomeric ring disassembly by BRME1 promotes homologous recombination (2023, Science Advances)
  • Publisher Correction: Molecular basis of microhomology-mediated end-joining by purified full-length Polθ (2020, Nature Communications)
  • Distinct mobility patterns of BRCA2 molecules at DNA damage sites (2023, bioRxiv - Cold Spring Harbor Laboratory)

Their work is regularly published in venues such as bioRxiv, Zenodo, Nucleic Acids Research, UNC Libraries, eLife, and Science Advances, with bioRxiv and Zenodo hosting multiple contributions.

Wyman frequently collaborates with other researchers in their field. Regular co-authors include:

  • Roland Kanaar
  • Dejan Ristić
  • Alex N. Zelensky
  • Jesse Aaron
  • Eric Wait

Best Publications

  • DNA Double-Strand Break Repair: All's Well that Ends Well

    Claire Wyman;Roland Kanaar

  • BLM–DNA2–RPA–MRN and EXO1–BLM–RPA–MRN constitute two DNA end resection machineries for human DNA break repair

    Amitabh V. Nimonkar;Jochen Genschel;Eri Kinoshita;Piotr Polaczek

  • Human Rad50/Mre11 is a flexible complex that can tether DNA ends.

    Martijn de Jager;John van Noort;Dik C. van Gent;Cees Dekker

  • DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities.

    Atsushi Shibata;Atsushi Shibata;Davide Moiani;Davide Moiani;Andrew S. Arvai;Andrew S. Arvai;Jefferson Perry;Jefferson Perry;Jefferson Perry

  • H-NS mediated compaction of DNA visualised by atomic force microscopy

    Remus Thei Dame;Claire Wyman;Nora Goosen

  • Unusual Oligomerization Required for Activity of NtrC, a Bacterial Enhancer-Binding Protein

    Claire Wyman;Irene Rombel;Anne K. North;Carlos Bustamante

  • The structure‐specific endonuclease Mus81–Eme1 promotes conversion of interstrand DNA crosslinks into double‐strands breaks

    Katsuhiro Hanada;Magdalena Budzowska;Mauro Modesti;Alex Maas

  • Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA

    Fernando Moreno-Herrero;Martijn de Jager;Nynke H. Dekker;Roland Kanaar

  • Homologous recombination-mediated double-strand break repair

    Claire Wyman;Dejan Ristic;Roland Kanaar

  • Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore.

    Claudio Ciferri;Jennifer De Luca;Silvia Monzani;Karin J. Ferrari

  • Structural basis for H-NS-mediated trapping of RNA polymerase in the open initiation complex at the rrnB P1

    Remus Thei Dame;Claire Wyman;Reinhild Wurm;Rolf Wagner

  • Counting RAD51 proteins disassembling from nucleoprotein filaments under tension

    Joost van Mameren;Mauro Modesti;Mauro Modesti;Roland Kanaar;Claire Wyman

  • Conformational changes in CLIP-170 regulate its binding to microtubules and dynactin localization

    Gideon Lansbergen;Yulia Komarova;Yulia Komarova;Mauro Modesti;Claire Wyman

  • Rad54, a Jack of all trades in homologous recombination

    T.L. Raoul Tan;Roland Kanaar;Claire Wyman

  • A human XRCC4–XLF complex bridges DNA

    Sara N. Andres;Alexandra Vergnes;Dejan Ristic;Claire Wyman

  • Regulation of DNA strand exchange in homologous recombination.

    J. Thomas Holthausen;Claire Wyman;Roland Kanaar

  • The architecture of the human Rad54-DNA complex provides evidence for protein translocation along DNA.

    Dejan Ristic;Claire Wyman;Coen Paulusma;Roland Kanaar

  • Nanoparticle-induced fluorescence lifetime modification as nanoscopic ruler: demonstration at the single molecule level.

    J. Seelig;K. Leslie;A. Renn;S. Kuhn

  • A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51

    Najim Ameziane;Patrick May;Anneke Haitjema;Henri J. van de Vrugt;Henri J. van de Vrugt

  • Human Rad51 filaments on double- and single-stranded DNA: correlating regular and irregular forms with recombination function

    Dejan Ristic;Mauro Modesti;Thijn van der Heijden;John van Noort

Frequent Co-Authors

Roland Kanaar
Roland Kanaar Erasmus University Rotterdam
Jan H.J. Hoeijmakers
Jan H.J. Hoeijmakers Erasmus University Rotterdam
Cees Dekker
Cees Dekker Delft University of Technology
Wim Vermeulen
Wim Vermeulen Erasmus University Rotterdam
Gijs J. L. Wuite
Gijs J. L. Wuite Vrije Universiteit Amsterdam
Jeroen Essers
Jeroen Essers Erasmus University Rotterdam
John A. Tainer
John A. Tainer The University of Texas MD Anderson Cancer Center
Dik C. van Gent
Dik C. van Gent Erasmus University Rotterdam
Andrew S. Arvai
Andrew S. Arvai Scripps Research Institute

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