World's Best Scientists 2026 revealed!
Mauro Modesti

Mauro Modesti

D-Index & Metrics

Molecular Biology

D-Index
45
Citations
7552
World Ranking
2862
National Ranking
108

Overview

Mauro Modesti is affiliated with Aix-Marseille University in France and specializes in Biochemistry, Genetics, and Molecular Biology. Their research primarily focuses on Molecular Biology, with additional work in Oncology, Genetics, Immunology, and Cell Biology.

Their recent scientific publications include:

  • Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling, 2021, Nature Communications
  • Sequential role of RAD51 paralog complexes in replication fork remodeling and restart, 2020, Nature Communications
  • RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA, 2022, Molecular Cell
  • Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex, 2021, Nature Communications
  • STING protects breast cancer cells from intrinsic and genotoxic-induced DNA instability via a non-canonical, cell-autonomous pathway, 2021, Oncogene

The main topics covered in their research include:

  • DNA Repair Mechanisms
  • Genomics and Chromatin Dynamics
  • CRISPR and Genetic Engineering
  • PARP inhibition in cancer therapy
  • DNA and Nucleic Acid Chemistry
  • RNA Research and Splicing
  • RNA modifications and cancer

Frequent publication venues for their work are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Cell
  • Nature Communications
  • Nucleic Acids Research
  • Proceedings of the National Academy of Sciences

Mauro Modesti regularly collaborates with several co-authors, including:

  • Florian Morati
  • Lulu Bi
  • Xi-Miao Hou
  • Bo Sun
  • Manon Brenière

Best Publications

  • Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4

    Pierre-Olivier Mari;Bogdan I. Florea;Stephan P. Persengiev;Nicole S. Verkaik

  • Rab6 Regulates Transport and Targeting of Exocytotic Carriers

    Ilya Grigoriev;Daniël Splinter;Nanda Keijzer;Phebe S. Wulf

  • The structure‐specific endonuclease Mus81–Eme1 promotes conversion of interstrand DNA crosslinks into double‐strands breaks

    Katsuhiro Hanada;Magdalena Budzowska;Mauro Modesti;Alex Maas

  • Unraveling the structure of DNA during overstretching by using multicolor, single-molecule fluorescence imaging

    Joost van Mameren;Peter Gross;Geraldine Farge;Pleuni Hooijman

  • DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity.

    Mauro Modesti;Joanne E. Hesse;Martin Gellert

  • Crystal structure of the Xrcc4 DNA repair protein and implications for end joining.

    Murray S. Junop;Mauro Modesti;Alba Guarné;Rodolfo Ghirlando

  • Counting RAD51 proteins disassembling from nucleoprotein filaments under tension

    Joost van Mameren;Mauro Modesti;Mauro Modesti;Roland Kanaar;Claire Wyman

  • Conformational changes in CLIP-170 regulate its binding to microtubules and dynactin localization

    Gideon Lansbergen;Yulia Komarova;Yulia Komarova;Mauro Modesti;Claire Wyman

  • A human XRCC4–XLF complex bridges DNA

    Sara N. Andres;Alexandra Vergnes;Dejan Ristic;Claire Wyman

  • Revealing the competition between peeled ssDNA, melting bubbles, and S-DNA during DNA overstretching using fluorescence microscopy

    Graeme A. King;Peter Gross;Ulrich Bockelmann;Mauro Modesti

  • DNA repair: Spot(light)s on chromatin

    Mauro Modesti;Roland Kanaar

  • Crystal Structure of Human XLF: A Twist in Nonhomologous DNA End-Joining

    Sara N. Andres;Mauro Modesti;Chun J. Tsai;Gilbert Chu

  • Sliding sleeves of XRCC4–XLF bridge DNA and connect fragments of broken DNA

    Ineke Brouwer;Gerrit Sitters;Gerrit Sitters;Andrea Candelli;Andrea Candelli;Stephanie J. Heerema;Stephanie J. Heerema

  • Structural and Functional Interaction between the Human DNA Repair Proteins DNA Ligase IV and XRCC4

    Peï Yu Wu;Philippe Frit;Philippe Frit;Srilakshmi Meesala;Stéphanie Dauvillier;Stéphanie Dauvillier

  • DNA-binding and strand-annealing activities of human Mre11: implications for its roles in DNA double-strand break repair pathways

    Martijn de Jager;Mies L. G. Dronkert;Mauro Modesti;Cecile E. M. T. Beerens

  • Human Rad51 filaments on double- and single-stranded DNA: correlating regular and irregular forms with recombination function

    Dejan Ristic;Mauro Modesti;Thijn van der Heijden;John van Noort

  • Real-time assembly and disassembly of human RAD51 filaments on individual DNA molecules

    Thijn van der Heijden;Ralf Seidel;Mauro Modesti;Roland Kanaar

  • A noncatalytic function of the ligation complex during nonhomologous end joining

    Jessica Cottarel;Philippe Frit;Philippe Frit;Oriane Bombarde;Oriane Bombarde;Bernard Salles;Bernard Salles

  • Homologous Recombination in Real Time: DNA Strand Exchange by RecA

    Thijn van der Heijden;Mauro Modesti;Susanne Hage;Roland Kanaar

  • RAD51AP1 is a structure-specific DNA binding protein that stimulates joint molecule formation during RAD51-mediated homologous recombination.

    Mauro Modesti;Magda Budzowska;Céline Baldeyron;Jeroen A.A. Demmers

Frequent Co-Authors

Gijs J. L. Wuite
Gijs J. L. Wuite Vrije Universiteit Amsterdam
Roland Kanaar
Roland Kanaar Erasmus University Rotterdam
Claire Wyman
Claire Wyman Erasmus MC
Cees Dekker
Cees Dekker Delft University of Technology
Bernard Salles
Bernard Salles Paul Sabatier University
Rodolfo Ghirlando
Rodolfo Ghirlando National Institutes of Health
Maria Jasin
Maria Jasin Memorial Sloan Kettering Cancer Center
Maria Falkenberg
Maria Falkenberg University of Gothenburg
Anna Akhmanova
Anna Akhmanova Utrecht University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring molecular biology opens a range of interdisciplinary opportunities, especially through flexible online education. Many students are interested in expanding their expertise with graduate-level credentials. If you’re considering further study, a masters in history can provide a strong foundation in research and analytical skills—a great complement to scientific training.

For those who are budget-conscious, understanding the cost of mlis degree us options is essential. Affordable online programs allow you to develop skills in information management, which are highly valuable if you anticipate a career that blends molecular biology with library or data sciences.

Interested in health-related communication? There are asha approved slp programs online that let you work toward credentials in speech-language pathology—an area with significant crossover in biological research and healthcare.

If you do not have a background in communication sciences but are considering that path, an slp bridge program online makes this transition possible. These programs are designed to help non-majors gain the necessary prerequisites for graduate study in communication sciences.

Best Scientists Citing Mauro Modesti

Trending Scientists

Recently Published Articles