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Immunology

D-Index
71
Citations
17700
World Ranking
2323
National Ranking
1122

Overview

Patricia L. Earl is affiliated with the National Institute of Allergy and Infectious Diseases in the United States. Their research spans multiple areas within medicine, focusing notably on infectious diseases and immunology. Their work includes significant contributions to the study of poxviruses, herpesviruses, bacterial pathogens, and viral infections such as SARS-CoV-2.

The main fields of study for Patricia L. Earl include Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. Within these broader fields, their research subfields cover Epidemiology, Virology, Molecular Biology, Infectious Diseases, and Immunology.

The research topics that have been central to their work are:

  • Poxvirus research and outbreaks
  • Herpesvirus Infections and Treatments
  • Bacillus and Francisella bacterial research
  • SARS-CoV-2 and COVID-19 Research
  • Immunotherapy and Immune Responses
  • Drug-Induced Adverse Reactions
  • Virus-based gene therapy research

Patricia L. Earl has published extensively in well-regarded scientific journals. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Journal of Allergy and Clinical Immunology
  • Cell
  • npj Vaccines

Frequent collaborators in their research include Bernard Moss, Jeffrey L. Americo, Catherine A. Cotter, Alec W. Freyn, and Tiffany R. Frey. These coauthors have worked with Earl on various aspects of infectious disease research and immunology.

Some recent papers authored by Patricia L. Earl are:

  • Virulence differences of mpox (monkeypox) virus clades I, IIa, and IIb.1 in a small animal model, 2023, Proceedings of the National Academy of Sciences
  • An mpox virus mRNA-lipid nanoparticle vaccine confers protection against lethal orthopoxviral challenge, 2023, Science Translational Medicine
  • Comparison of protection against mpox following mRNA or modified vaccinia Ankara vaccination in nonhuman primates, 2024, Cell
  • One or two injections of MVA-vectored vaccine shields hACE2 transgenic mice from SARS-CoV-2 upper and lower respiratory tract infection, 2021, Proceedings of the National Academy of Sciences
  • Intranasal inoculation of an MVA-based vaccine induces IgA and protects the respiratory tract of hACE2 mice from SARS-CoV-2 infection, 2022, Proceedings of the National Academy of Sciences

Best Publications

  • Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.

    Rama Rao Amara;Francois Villinger;John D. Altman;Shari L. Lydy

  • In vitro mutagenesis identifies a region within the envelope gene of the human immunodeficiency virus that is critical for infectivity.

    R L Willey;D H Smith;L A Lasky;T S Theodore

  • Generation of Recombinant Vaccinia Viruses

    Linda S. Wyatt;Patricia L. Earl;Bernard Moss

  • Use of a hybrid vaccinia virus-T7 RNA polymerase system for expression of target genes.

    T R Fuerst;P L Earl;B Moss

  • Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox

    Patricia L. Earl;Jeffrey L. Americo;Linda S. Wyatt;Leigh Anne Eller

  • Oligomeric structure of the human immunodeficiency virus type 1 envelope glycoprotein

    Patricia L. Earl;Robert W. Doms;Bernard Moss

  • Folding, interaction with GRP78-BiP, assembly, and transport of the human immunodeficiency virus type 1 envelope protein.

    P L Earl;B Moss;R W Doms

  • Mucosal immunization with HIV-1 peptide vaccine induces mucosal and systemic cytotoxic T lymphocytes and protective immunity in mice against intrarectal recombinant HIV-vaccinia challenge

    Igor M. Belyakov;Michael A. Derby;Jeffrey D. Ahlers;Brian L. Kelsall

  • Conserved TAAATG sequence at the transcriptional and translational initiation sites of vaccinia virus late genes deduced by structural and functional analysis of the HindIII H genome fragment.

    J L Rosel;P L Earl;J P Weir;B Moss

  • Protective Efficacy of a Global HIV-1 Mosaic Vaccine against Heterologous SHIV Challenges in Rhesus Monkeys

    Dan H. Barouch;Dan H. Barouch;Kathryn E. Stephenson;Erica N. Borducchi;Kaitlin Smith

  • Identification of the fusion peptide of primate immunodeficiency viruses.

    Marnix L. Bosch;Patricia L. Earl;Kathleen Fargnoli;Silvia Picciafuoco

  • Highly attenuated smallpox vaccine protects mice with and without immune deficiencies against pathogenic vaccinia virus challenge

    Linda S. Wyatt;Patricia L. Earl;Leigh Anne Eller;Bernard Moss

  • Biological and immunological properties of human immunodeficiency virus type 1 envelope glycoprotein: analysis of proteins with truncations and deletions expressed by recombinant vaccinia viruses

    P L Earl;S Koenig;B Moss

  • Preparation of Cell Cultures and Vaccinia Virus Stocks

    Patricia L. Earl;Norman Cooper;Linda S. Wyatt;Bernard Moss

  • Shared modes of protection against poxvirus infection by attenuated and conventional smallpox vaccine viruses

    Igor M. Belyakov;Patricia Earl;Amiran Dzutsev;Vladimir A. Kuznetsov

  • Native oligomeric human immunodeficiency virus type 1 envelope glycoprotein elicits diverse monoclonal antibody reactivities.

    P. L. Earl;C. C. Broder;D. Long;S. A. Lee

  • Removal of cryptic poxvirus transcription termination signals from the human immunodeficiency virus type 1 envelope gene enhances expression and immunogenicity of a recombinant vaccinia virus.

    P L Earl;A W Hügin;B Moss

  • The importance of local mucosal HIV-specific CD8(+) cytotoxic T lymphocytes for resistance to mucosal viral transmission in mice and enhancement of resistance by local administration of IL-12.

    Igor M. Belyakov;Jeffrey D. Ahlers;Benjamin Y. Brandwein;Patricia Earl

  • Homology between DNA polymerases of poxviruses, herpesviruses, and adenoviruses: nucleotide sequence of the vaccinia virus DNA polymerase gene

    Patricia L. Earl;Elaine V. Jones;Bernard Moss

  • Critical Role for Env as well as Gag-Pol in Control of a Simian-Human Immunodeficiency Virus 89.6P Challenge by a DNA Prime/Recombinant Modified Vaccinia Virus Ankara Vaccine

    Rama Rao Amara;James M. Smith;James M. Smith;Silvija I. Staprans;David C. Montefiori

  • Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine

    Rama Rao Amara;Francois Villinger;John D Altman;Shari L Lydy;Shari L Lydy

Frequent Co-Authors

Bernard Moss
Bernard Moss National Institutes of Health
Linda S. Wyatt
Linda S. Wyatt National Institutes of Health
Rama Rao Amara
Rama Rao Amara Emory University
David C. Montefiori
David C. Montefiori Duke University
Harriet L. Robinson
Harriet L. Robinson Emory University
Britta Wahren
Britta Wahren Karolinska Institute
Merlin L. Robb
Merlin L. Robb Walter Reed Army Institute of Research
Robert W. Doms
Robert W. Doms Children's Hospital of Philadelphia
Eric Sandström
Eric Sandström Karolinska Institute
Christopher C. Broder
Christopher C. Broder Uniformed Services University of the Health Sciences

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