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Gunnar K. Gouras

Gunnar K. Gouras

D-Index & Metrics

Neuroscience

D-Index
55
Citations
16242
World Ranking
4633
National Ranking
89

Overview

Gunnar K. Gouras is affiliated with Lund University in Sweden, focusing primarily on Medicine and Neuroscience. Their scholarly work spans 67 publications in Medicine and 42 in Neuroscience, with substantial contributions also made to subfields such as Physiology, Neurology, Cellular and Molecular Neuroscience, Molecular Biology, and Biophysics.

The scientist's main research topics include Alzheimer's disease research and treatments, neuroinflammation and neurodegeneration mechanisms, neuroscience and neuropharmacology research, Parkinson's disease mechanisms and treatments, nuclear receptors and signaling, spectroscopy techniques in biomedical and chemical research, and computational drug discovery methods.

Several recent papers illustrate the scope of their research interests and collaborations. Notable publications comprise:

  • APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases, 2022, Molecular Neurodegeneration
  • Super-Resolution Infrared Imaging of Polymorphic Amyloid Aggregates Directly in Neurons, 2020, Advanced Science
  • Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies, 2020, Stem Cell Reports
  • Upregulation of APP endocytosis by neuronal aging drives amyloid-dependent synapse loss, 2021, Journal of Cell Science
  • Galectin-3 is elevated in CSF and is associated with Aβ deposits and tau aggregates in brain tissue in Alzheimer's disease, 2022, Acta Neuropathologica

The scientist frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Alzheimer's & Dementia, Stem Cell Reports, Journal of Alzheimer's Disease, and Advanced Science. These outlets reflect the interdisciplinary nature of their work combining biomedical research and clinical neuroscience.

Collaborative efforts are a substantive aspect of their work. Frequent co-authors include Isak Martinsson, Oxana Klementieva, Sabine C Konings, Tomas Deierborg, and Laura Torres-Garcia. Such partnerships highlight an extensive network within the neuroscience and neurobiology research community.

Best Publications

  • Regulation of NMDA receptor trafficking by amyloid-beta.

    Eric M Snyder;Yi Nong;Claudia G Almeida;Surojit Paul

  • Intraneuronal Aβ42 Accumulation in Human Brain

    Gunnar K. Gouras;Gunnar K. Gouras;Julia Tsai;Jan Naslund;Bruno Vincent

  • Intraneuronal Alzheimer Aβ42 Accumulates in Multivesicular Bodies and Is Associated with Synaptic Pathology

    Reisuke H. Takahashi;Reisuke H. Takahashi;Teresa A. Milner;Feng Li;Ellen E. Nam

  • Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.

    Huaxi Xu;Gunnar K. Gouras;Jeffrey P. Greenfield;Bruno Vincent

  • Stimulation of β-Amyloid Precursor Protein Trafficking by Insulin Reduces Intraneuronal β-Amyloid and Requires Mitogen-Activated Protein Kinase Signaling

    Laura Gasparini;Gunnar K. Gouras;Rong Wang;Rachel S. Gross

  • Oligomerization of Alzheimer's β-Amyloid within Processes and Synapses of Cultured Neurons and Brain

    Reisuke H. Takahashi;Claudia G. Almeida;Patrick F. Kearney;Fangmin Yu

  • Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-amyloid peptides

    Jeffrey P. Greenfield;Julia Tsai;Gunnar K. Gouras;Gunnar K. Gouras;Bing Hai

  • Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses.

    Claudia G. Almeida;Davide Tampellini;Reisuke H. Takahashi;Paul Greengard

  • Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease

    Gunnar K. Gouras;Davide Tampellini;Reisuke H. Takahashi;Estibaliz Capetillo-Zarate

  • Testosterone reduces neuronal secretion of Alzheimer's β-amyloid peptides

    Gunnar K. Gouras;Huaxi Xu;Rachel S. Gross;Jeffrey P. Greenfield

  • Intraneuronal Aβ accumulation and origin of plaques in Alzheimer's disease

    Gunnar K. Gouras;Claudia G. Almeida;Reisuke H. Takahashi

  • β-Amyloid Accumulation Impairs Multivesicular Body Sorting by Inhibiting the Ubiquitin-Proteasome System

    Claudia G. Almeida;Reisuke H. Takahashi;Gunnar K. Gouras

  • Plaque formation and the intraneuronal accumulation of β-amyloid in Alzheimer's disease.

    Reisuke H. Takahashi;Toshitaka Nagao;Gunnar K. Gouras

  • β-amyloid Peptides and Amyloid Plaques in Alzheimer's Disease.

    Gunnar K. Gouras;Tomas T. Olsson;Oskar Hansson

  • Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice

    Feng Li;Noel Y. Calingasan;Fangmin Yu;William M. Mauck

  • APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases

    Unknown

  • Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

    Tao Ma;Charles A. Hoeffer;Estibaliz Capetillo-Zarate;Fangmin Yu

  • Conditional Inactivation of Presenilin 1 Prevents Amyloid Accumulation and Temporarily Rescues Contextual and Spatial Working Memory Impairments in Amyloid Precursor Protein Transgenic Mice

    Carlos A. Saura;Guiquan Chen;Seema Malkani;Se Young Choi

  • Effects of Synaptic Modulation on β-Amyloid, Synaptophysin, and Memory Performance in Alzheimer's Disease Transgenic Mice

    Davide Tampellini;Estibaliz Capetillo-Zarate;Magali Dumont;Zhenyong Huang

  • Evidence for phosphorylation and oligomeric assembly of presenilin 1

    Mary Seeger;Christer Nordstedt;Suzana Petanceska;Suzana Petanceska;Dora M. Kovacs

  • COMMUNICATION Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice

    Feng Li;Noel Y. Calingasan;Fangmin Yu;William M. Mauck

Frequent Co-Authors

Paul Greengard
Paul Greengard Rockefeller University
Huaxi Xu
Huaxi Xu Xiamen University
Teresa A. Milner
Teresa A. Milner Cornell University
M. Flint Beal
M. Flint Beal Cornell University
Patrik Brundin
Patrik Brundin Roche (United States)
Vassilis E. Koliatsos
Vassilis E. Koliatsos Johns Hopkins University School of Medicine
Sangram S. Sisodia
Sangram S. Sisodia University of Chicago
Keith A. Crutcher
Keith A. Crutcher University of Cincinnati
Joseph D. Buxbaum
Joseph D. Buxbaum Icahn School of Medicine at Mount Sinai
Chao Wang
Chao Wang Soochow University

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