Anja Capell

Overview

Best Publications

• ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import

  Dorothee Dormann;Dorothee Dormann;Ramona Rodde;Ramona Rodde;Dieter Edbauer;Eva Bentmann;Eva Bentmann

  887
  Citations

• The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway.

  Christian Haass;Cynthia A. Lemere;Anja Capell;Anja Capell;Martin Citron

  806
  Citations

• Presenilin-dependent γ-secretase processing of β-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

  Magdalena Sastre;Harald Steiner;Klaus Fuchs;Anja Capell

  643
  Citations

• The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue

  Taisuke Tomita;Kei Maruyama;Takaomi C. Saido;Hideaki Kume

  527
  Citations

• The Proteolytic Fragments of the Alzheimer’s Disease-associated Presenilin-1 Form Heterodimers and Occur as a 100–150-kDa Molecular Mass Complex

  Anja Capell;Jürgen Grünberg;Brigitte Pesold;Anke Diehlmann

  443
  Citations

• Intracellular Generation and Accumulation of Amyloid β-Peptide Terminating at Amino Acid 42 *

  Christine Wild-Bode;Tsuneo Yamazaki;Anja Capell;Uwe Leimer

  410
  Citations

• A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling.

  Harald Steiner;Karen Duff;Anja Capell;Helmut Romig

  402
  Citations

• Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.

  Sven Lammich;Masayasu Okochi;Masatoshi Takeda;Christoph Kaether

  385
  Citations

• Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

  Harald Steiner;Marcus Kostka;Helmut Romig;Gabriele Basset

  382
  Citations

• Phosphorylation Regulates Intracellular Trafficking of β-Secretase

  Jochen Walter;Regina Fluhrer;Bianka Hartung;Michael Willem

  373
  Citations

• Maturation and Pro-peptide Cleavage of β-Secretase

  Anja Capell;Harald Steiner;Michael Willem;Hartmut Kaiser

  367
  Citations

• TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.

  Fargol Mazaheri;Nicolas Snaidero;Nicolas Snaidero;Gernot Kleinberger;Charlotte Madore

  356
  Citations

• Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

  Marc Suárez-Calvet;Marc Suárez-Calvet;Estrella Morenas-Rodríguez;Estrella Morenas-Rodríguez;Gernot Kleinberger;Kai Schlepckow

  354
  Citations

• Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Aβ42 production

  Tobias Moehlmann;Edith Winkler;Xuefeng Xia;Dieter Edbauer

  321
  Citations

• The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum.

  Jochen Walter;Anja Capell;Jürgen Grünberg;Brigitte Pesold

  298
  Citations

• Expression of Alzheimer’s Disease-associated Presenilin-1 Is Controlled by Proteolytic Degradation and Complex Formation

  Harald Steiner;Anja Capell;Brigitte Pesold;Martin Citron

  291
  Citations

• Presenilin-1 affects trafficking and processing of βAPP and is targeted in a complex with nicastrin to the plasma membrane

  Christoph Kaether;Sven Lammich;Dieter Edbauer;Michaela Ertl

  249
  Citations

• Missense Mutations in the Progranulin Gene Linked to Frontotemporal Lobar Degeneration with Ubiquitin-immunoreactive Inclusions Reduce Progranulin Production and Secretion

  Sunita S. Shankaran;Anja Capell;Alexander T. Hruscha;Katrin Fellerer

  233
  Citations

• Presenilin-1 differentially facilitates endoproteolysis of the β-amyloid precursor protein and Notch

  Anja Capell;Harald Steiner;Helmut Romig;Simone Keck

  215
  Citations

• The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes

  Benjamin M Schwenk;Christina M Lang;Sebastian Hogl;Sabina Tahirovic

  206
  Citations