His main research concerns Biochemistry, Amyloid precursor protein, APH-1, Presenilin and Cell biology. Gopal Thinakaran focuses mostly in the field of Biochemistry, narrowing it down to topics relating to Alpha secretase and, in certain cases, Senile plaques. As a member of one scientific family, Gopal Thinakaran mostly works in the field of Amyloid precursor protein, focusing on Amyloid and, on occasion, Alzheimer's disease, Neuroscience and Endocrinology.
Gopal Thinakaran has researched APH-1 in several fields, including PEN-2, Gamma-secretase complex and Nicastrin. The concepts of his Presenilin study are interwoven with issues in Molecular biology, Gene and Proteolysis. Gopal Thinakaran has included themes like Secretion and Cleavage in his Cell biology study.
His primary areas of investigation include Amyloid precursor protein, Cell biology, Presenilin, Biochemistry and Neuroscience. His work deals with themes such as Senile plaques and Amyloid, which intersect with Amyloid precursor protein. His study focuses on the intersection of Cell biology and fields such as Transmembrane protein with connections in the field of Ectodomain.
Gopal Thinakaran combines subjects such as Molecular biology, Gene and Membrane protein with his study of Presenilin. Gopal Thinakaran interconnects Dementia and Neurodegeneration in the investigation of issues within Neuroscience. His APH-1 research integrates issues from PEN-2 and Gamma-secretase complex.
Gopal Thinakaran spends much of his time researching Cell biology, Amyloid precursor protein, Neuroscience, Amyloid and Receptor. His studies deal with areas such as Presenilin and Senile plaques as well as Cell biology. His Presenilin research includes elements of Transgene, Mutation, Protease, Exon and Alpha secretase.
Particularly relevant to Amyloid precursor protein secretase is his body of work in Amyloid precursor protein. As part of his studies on Amyloid precursor protein secretase, Gopal Thinakaran often connects relevant areas like Biochemistry. His study in Amyloid is interdisciplinary in nature, drawing from both Biophysics, P3 peptide and Signal transducing adaptor protein.
Gopal Thinakaran focuses on Amyloid precursor protein, Cell biology, Neuroscience, Receptor and Alzheimer's disease. Gopal Thinakaran has included themes like Biochemistry and Protease in his Amyloid precursor protein study. His Biochemistry study combines topics in areas such as Dynein, Microtubule, P3 peptide and Axoplasmic transport.
The various areas that Gopal Thinakaran examines in his Neuroscience study include Disease etiology, Disease pathogenesis, Function, Cell surface receptor and Signaling proteins. His work carried out in the field of Alzheimer's disease brings together such families of science as Human brain, Multiple sclerosis and Alternative splicing. His Amyloid precursor protein secretase study incorporates themes from Alpha secretase, Presenilin, Proteolysis and Amyloid.
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Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo
David R. Borchelt;Gopal Thinakaran;Christopher B. Eckman;Christopher B. Eckman;Michael K. Lee.
ENDOPROTEOLYSIS OF PRESENILIN 1 AND ACCUMULATION OF PROCESSED DERIVATIVES IN VIVO
Gopal Thinakaran;David R Borchelt;Michael K Lee;Hilda H Slunt.
Amyloid Precursor Protein Trafficking, Processing, and Function
Gopal Thinakaran;Edward H. Koo.
Journal of Biological Chemistry (2008)
The role of presenilin cofactors in the γ-secretase complex
Nobumasa Takasugi;Taisuke Tomita;Ikuo Hayashi;Makiko Tsuruoka.
Trafficking and Proteolytic Processing of APP
Christian Haass;Christoph Kaether;Gopal Thinakaran;Sangram Sisodia.
Cold Spring Harbor Perspectives in Medicine (2012)
Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.
Huaxi Xu;Gunnar K. Gouras;Jeffrey P. Greenfield;Bruno Vincent.
Nature Medicine (1998)
Protein Topology of Presenilin 1
Andrew Doan;Gopal Thinakaran;David R Borchelt;Hilda H Slunt.
Association of γ-Secretase with Lipid Rafts in Post-Golgi and Endosome Membranes
Kulandaivelu S. Vetrivel;Haipeng Cheng;William Lin;Takashi Sakurai.
Journal of Biological Chemistry (2004)
ASSESSMENT OF NORMAL AND MUTANT HUMAN PRESENILIN FUNCTION IN CAENORHABDITIS ELEGANS
Diane Levitan;Timothy G. Doyle;Denise Brousseau;Michael K. Lee.
Proceedings of the National Academy of Sciences of the United States of America (1996)
Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-amyloid peptides
Jeffrey P. Greenfield;Julia Tsai;Gunnar K. Gouras;Gunnar K. Gouras;Bing Hai.
Proceedings of the National Academy of Sciences of the United States of America (1999)
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