World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
73
Citations
23940
World Ranking
5845
National Ranking
2766

Overview

Gopal Thinakaran is affiliated with the University of Chicago in the United States. Their research primarily focuses on Alzheimer's disease and related neurodegenerative conditions, integrating multiple fields such as medicine, biochemistry, genetics, and molecular biology.

The scientist's main areas of study encompass physiology, molecular biology, cell biology, neurology, and cellular and molecular neuroscience. Their research themes include Alzheimer's disease research and treatments, neuroinflammation and neurodegeneration mechanisms, immune cells in cancer, neuroscience and neuropharmacology research, cellular transport and secretion, cholinesterase and neurodegenerative diseases, and computational drug discovery methods.

Among the prominent recent publications authored by Gopal Thinakaran are:

  • "BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia," 2022, Molecular Neurodegeneration
  • "Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation," 2020, Cell Reports
  • "Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention," 2021, The Journal of Experimental Medicine
  • "Significance of cytosolic cathepsin D in Alzheimer's disease pathology: Protective cellular effects of PLGA nanoparticles against β-amyloid-toxicity," 2020, Neuropathology and Applied Neurobiology
  • "Alzheimer's genes in microglia: a risk worth investigating," 2023, Molecular Neurodegeneration

Gopal Thinakaran frequently publishes in journals such as Molecular Neurodegeneration, bioRxiv (Cold Spring Harbor Laboratory), Cell Reports, The Journal of Experimental Medicine, and Neuropathology and Applied Neurobiology.

Their research collaborations include frequent co-authorship with researchers such as Ari Sudwarts, Moorthi Ponnusamy, Shuai Wang, Alena Kozlova, and Jubao Duan.

Best Publications

  • Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

    David R. Borchelt;Gopal Thinakaran;Christopher B. Eckman;Christopher B. Eckman;Michael K. Lee

  • Amyloid Precursor Protein Trafficking, Processing, and Function

    Gopal Thinakaran;Edward H. Koo

  • ENDOPROTEOLYSIS OF PRESENILIN 1 AND ACCUMULATION OF PROCESSED DERIVATIVES IN VIVO

    Gopal Thinakaran;David R Borchelt;Michael K Lee;Hilda H Slunt

  • Trafficking and Proteolytic Processing of APP

    Christian Haass;Christoph Kaether;Gopal Thinakaran;Sangram Sisodia

  • The role of presenilin cofactors in the gamma-secretase complex.

    Nobumasa Takasugi;Taisuke Tomita;Ikuo Hayashi;Makiko Tsuruoka

  • Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.

    Huaxi Xu;Gunnar K. Gouras;Jeffrey P. Greenfield;Bruno Vincent

  • Association of γ-Secretase with Lipid Rafts in Post-Golgi and Endosome Membranes

    Kulandaivelu S. Vetrivel;Haipeng Cheng;William Lin;Takashi Sakurai

  • Protein Topology of Presenilin 1

    Andrew Doan;Gopal Thinakaran;David R Borchelt;Hilda H Slunt

  • Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-amyloid peptides

    Jeffrey P. Greenfield;Julia Tsai;Gunnar K. Gouras;Gunnar K. Gouras;Bing Hai

  • ASSESSMENT OF NORMAL AND MUTANT HUMAN PRESENILIN FUNCTION IN CAENORHABDITIS ELEGANS

    Diane Levitan;Timothy G. Doyle;Denise Brousseau;Michael K. Lee

  • Effects of PS1 Deficiency on Membrane Protein Trafficking in Neurons

    Satoshi Naruse;Gopal Thinakaran;Jin Jun Luo;John W. Kusiak

  • Generation of APLP2 KO Mice and Early Postnatal Lethality in APLP2/APP Double KO Mice

    C.S. von Koch;H. Zheng;H. Chen;M. Trumbauer

  • Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP).

    H. H. Slunt;Gopal Thinakaran;C. Von Koch;A. C. Y. Lo

  • Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors

    Gopal Thinakaran;Christie L. Harris;Tamara Ratovitski;Frances Davenport

  • Metabolism of the Swedish Amyloid Precursor Protein Variant in Neuro2a (N2a) Cells EVIDENCE THAT CLEAVAGE AT THE “β-SECRETASE” SITE OCCURS IN THE GOLGI APPARATUS

    Gopal Thinakaran;David B. Teplow;Robert Siman;Barry Greenberg

  • Comparative evaluation of synaptophysin-based methods for quantification of synapses.

    Michael E. Calhoun;Mathias Jucker;Lee J. Martin;Gopal Thinakaran

  • Generation of Alzheimer β-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation

    Huaxi Xu;David Sweeney;Rong Wang;Gopal Thinakaran

  • Expression of Presenilin 1 and 2 (PS1 and PS2) in Human and Murine Tissues

    Michael K. Lee;Hilda H. Slunt;Lee J. Martin;Gopal Thinakaran

  • Membrane rafts in Alzheimer's disease beta-amyloid production.

    Kulandaivelu S. Vetrivel;Gopal Thinakaran

  • PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

    Wen jie Luo;Hong Wang;Hongqiao Li;Benny S. Kim

Frequent Co-Authors

Sangram S. Sisodia
Sangram S. Sisodia University of Chicago
Donald L. Price
Donald L. Price Johns Hopkins University
David R. Borchelt
David R. Borchelt University of Florida
Satyabrata Kar
Satyabrata Kar University of Alberta
Huaxi Xu
Huaxi Xu Xiamen University
Taisuke Tomita
Taisuke Tomita University of Tokyo
Takeshi Iwatsubo
Takeshi Iwatsubo University of Tokyo
Sam Gandy
Sam Gandy Icahn School of Medicine at Mount Sinai
Rong Wang
Rong Wang Icahn School of Medicine at Mount Sinai
Robert Vassar
Robert Vassar Northwestern University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Students passionate about Biology and Biochemistry can benefit from a range of online degree options that offer flexibility and diverse career prospects. Whether pursuing direct patient care, research, or wellness, online programs are widely accessible to help you reach your goals.

For those looking at advanced pharmacy roles, accredited pharmd online programs let you earn a doctorate with a blend of virtual coursework and clinical experiences. If understanding human movement and physical performance appeals to you, consider an online exercise physiology degree, or fast-track your education with an accelerated kinesiology degree online.

Mental health is another field with growing demand. Biology majors can extend their expertise with the shortest pmhnp certificate program to become a Psychiatric-Mental Health Nurse Practitioner.

These online programs not only open new professional pathways but also make advanced education more accessible for busy students and working adults.

Best Scientists Citing Gopal Thinakaran

Trending Scientists