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Steven H. Kleinstein

Steven H. Kleinstein

D-Index & Metrics

Biology and Biochemistry

D-Index
73
Citations
19240
World Ranking
5928
National Ranking
2806

Overview

Steven H. Kleinstein is affiliated with Yale University in the United States. Their research spans multiple areas within medicine, immunology, and molecular biology, with a significant focus on immunology and infectious diseases.

Kleinstein's work covers a broad range of topics, including:

  • T-cell and B-cell Immunology
  • Vaccines and immunoinformatics approaches
  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • Immune Cell Function and Interaction
  • Monoclonal and Polyclonal Antibodies Research
  • Long-Term Effects of COVID-19

The primary fields of study for Kleinstein's publications are:

  • Medicine
  • Immunology and Microbiology
  • Biochemistry, Genetics and Molecular Biology

Within these, the main subfields of focus include:

  • Immunology
  • Molecular Biology
  • Infectious Diseases
  • Epidemiology
  • Neurology

Kleinstein has contributed to several high-profile papers, including:

  • Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders, 2021, Science
  • Human germinal centres engage memory and naive B cells after influenza vaccination, 2020, Nature
  • Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children, 2021, Immunity
  • A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection, 2020, The Journal of Immunology
  • Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms, 2021, Cell Reports Medicine

Frequent publication venues for Kleinstein include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Immunology
  • Zenodo (CERN European Organization for Nuclear Research)
  • Nature Immunology
  • PLoS Computational Biology

Kleinstein has collaborated regularly with several co-authors, notably:

  • Ruth R. Montgomery
  • Kenneth B. Hoehn
  • Ofer Levy
  • David A. Hafler
  • Albert C. Shaw

Best Publications

  • Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.

    Ping Chih Ho;Jessica Dauz Bihuniak;Andrew N. MacIntyre;Matthew Staron

  • Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data

    Namita T. Gupta;Jason A. Vander Heiden;Mohamed Uduman;Daniel Gadala-Maria

  • Two levels of protection for the B cell genome during somatic hypermutation

    Man Liu;Jamie L. Duke;Daniel J. Richter;Daniel J. Richter;Carola G. Vinuesa

  • Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone

    Steven M. Kerfoot;Gur Yaari;Jaymin R. Patel;Kody L. Johnson

  • B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes

    Joel N. H. Stern;Gur Yaari;Gur Yaari;Jason A. Vander Heiden;George Church

  • pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires.

    Jason A. Vander Heiden;Gur Yaari;Mohamed Uduman;Joel N.H. Stern

  • CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype

    Griselda V Zuccarino-Catania;Saheli Sadanand;Florian J Weisel;Mary M Tomayko

  • Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders.

    Simone Brioschi;Wei Le Wang;Vincent Peng;Meng Wang

  • Definition of Germinal-Center B Cell Migration In Vivo Reveals Predominant Intrazonal Circulation Patterns

    Anja E. Hauser;Tobias Junt;Thorsten R. Mempel;Michael W. Sneddon

  • Differential Expression of Ly6C and T-bet Distinguish Effector and Memory Th1 CD4+ Cell Properties during Viral Infection

    Heather D. Marshall;Anmol Chandele;Yong Woo Jung;Yong Woo Jung;Hailong Meng

  • Human germinal centres engage memory and naive B cells after influenza vaccination.

    Jackson S. Turner;Julian Q. Zhou;Julianna Han;Aaron J. Schmitz

  • The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection

    Claudia X. Dominguez;Robert A. Amezquita;Robert A. Amezquita;Tianxia Guan;Tianxia Guan;Heather D. Marshall

  • Practical guidelines for B-cell receptor repertoire sequencing analysis

    Gur Yaari;Steven H. Kleinstein

  • Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity

    Krzysztof Bryniarski;Wlodzimierz Ptak;Asha Jayakumar;Kerstin Püllmann

  • Models of Somatic Hypermutation Targeting and Substitution Based on Synonymous Mutations from High-Throughput Immunoglobulin Sequencing Data

    Gur Yaari;Gur Yaari;Jason A. Vander Heiden;Mohamed Uduman;Daniel Gadala-Maria

  • Automated analysis of high-throughput B-cell sequencing data reveals a high frequency of novel immunoglobulin V gene segment alleles

    Daniel Gadala-Maria;Gur Yaari;Mohamed Uduman;Steven H. Kleinstein

  • The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies

    Devin Sok;Uri Laserson;Uri Laserson;Jonathan Laserson;Yi-Ping Liu

  • Salmonella Typhimurium type III secretion effectors stimulate innate immune responses in cultured epithelial cells.

    Vincent M. Bruno;Sebastian Hannemann;María Lara-Tejero;Richard A. Flavell

  • Correction: Corrigendum: Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection

    Caitlin Bohannon;Ryan Powers;Lakshmipriyadarshini Satyabhama;Ang Cui

  • Quantitative set analysis for gene expression: a method to quantify gene set differential expression including gene-gene correlations

    Gur Yaari;Christopher R. Bolen;Juilee Thakar;Steven H. Kleinstein

Frequent Co-Authors

Kevin C. O’Connor
Kevin C. O’Connor Yale University
Susan M. Kaech
Susan M. Kaech Salk Institute for Biological Studies
David A. Hafler
David A. Hafler Yale University
Ruth R. Montgomery
Ruth R. Montgomery Yale University
Akiko Iwasaki
Akiko Iwasaki Yale University
Mark J. Shlomchik
Mark J. Shlomchik University of Pittsburgh
Stuart C. Sealfon
Stuart C. Sealfon Icahn School of Medicine at Mount Sinai
Kei-Hoi Cheung
Kei-Hoi Cheung Yale University
Erol Fikrig
Erol Fikrig Yale University
George M. Church
George M. Church Harvard University

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