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Biology and Biochemistry

D-Index
55
Citations
10580
World Ranking
15088
National Ranking
1190

Overview

Meritxell Canals is affiliated with the University of Nottingham in the United Kingdom. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, Neuroscience, and Medicine, with a focus on Molecular Biology, Cellular and Molecular Neuroscience, Immunology, Oncology, and Physiology. The scientist's work addresses a range of key topics including Receptor Mechanisms and Signaling, Neuropeptides and Animal Physiology, Pharmacological Receptor Mechanisms and Effects, Chemokine Receptors and Signaling, Pain Mechanisms and Treatments, T-cell and B-cell Immunology, and Cancer, Stress, Anesthesia, and Immune Response.

Canals has contributed to several recent papers published in notable scientific venues, which include:

  • Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists, 2020, Science Signaling
  • Critical Assessment of G Protein-Biased Agonism at the μ-Opioid Receptor, 2020, Trends in Pharmacological Sciences
  • Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain, 2020, Proceedings of the National Academy of Sciences
  • The Life Cycle of the Mu-Opioid Receptor, 2020, Trends in Biochemical Sciences
  • Atypical opioid receptors: unconventional biology and therapeutic opportunities, 2021, Pharmacology & Therapeutics

The scientist frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), the Journal of Biological Chemistry, the British Journal of Pharmacology, ACS Chemical Neuroscience, and Pharmacology & Therapeutics.

Frequent co-authors collaborating with Canals include:

  • J. Robert Lane
  • Julie Sanchez
  • Jonathan A. Javitch
  • Herman D. Lim
  • Stefan Schulz

The body of work for Meritxell Canals shows a concentrated interest in opioid receptor pharmacology and signaling mechanisms, particularly the interactions and signaling pathways of G protein-coupled receptors. Their publications have investigated intrinsic efficacy of agonists, biased agonism, receptor life cycles, and endosomal signals relevant to pain relief.

Best Publications

  • Presynaptic Control of Striatal Glutamatergic Neurotransmission by Adenosine A1–A2A Receptor Heteromers

    Francisco Ciruela;Vicent Casadó;Ricardo J. Rodrigues;Rafael Luján

  • Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors

    Joëlle A. Hillion;Meritxell Canals;Maria Torvinen;Vicent Casado

  • Adenosine A2A-Dopamine D2 Receptor-Receptor Heteromerization QUALITATIVE AND QUANTITATIVE ASSESSMENT BY FLUORESCENCE AND BIOLUMINESCENCE ENERGY TRANSFER

    Meritxell Canals;Daniel Marcellino;Francesca Fanelli;Francisco Ciruela

  • Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs

    Ron O. Dror;Hillary F. Green;Celine Valant;David W. Borhani

  • The role of kinetic context in apparent biased agonism at GPCRs

    Carmen Klein Herenbrink;David A. Sykes;Prashant Donthamsetti;Meritxell Canals

  • Receptor heteromerization in adenosine A2A receptor signaling Relevance for striatal function and Parkinson’s disease

    Kjell Fuxe;L. F. Agnati;K. Jacobsen;J. Hillion

  • Pharmacological modulation of chemokine receptor function

    DJ Scholten;M Canals;D Maussang;L Roumen

  • Adenosine A2A and dopamine D2 heteromeric receptor complexes and their function

    Kjell Fuxe;Sergi Ferré;Meritxell Canals;Maria Torvinen

  • Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists.

    Alexander Gillis;Arisbel B. Gondin;Andrea Kliewer;Julie Sanchez;Julie Sanchez

  • Combining mass spectrometry and pull-down techniques for the study of receptor heteromerization. Direct epitope-epitope electrostatic interactions between adenosine A2A and dopamine D2 receptors.

    Francisco Ciruela;Javier Burgueño;Vicent Casadó;Meritxell Canals

  • Orexin-1 Receptor-Cannabinoid CB1 Receptor Heterodimerization Results in Both Ligand-dependent and -independent Coordinated Alterations of Receptor Localization and Function

    James Ellis;John D. Pediani;Meritxell Canals;Sandra Milasta

  • Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

    Dane D. Jensen;Tina Marie Lieu;Michelle L. Halls;Nicholas A. Veldhuis

  • Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer.

    Meritxell Canals;Javier Burgueño;Daniel Marcellino;Núria Cabello

  • Cannabinoid Receptor Type 1 Protects against Age- Related Osteoporosis by Regulating Osteoblast and Adipocyte Differentiation in Marrow Stromal Cells

    Aymen I. Idris;Antonia Sophocleous;Euphemie Landao-Bassonga;Meritxell Canals

  • The alpha1b-adrenoceptor exists as a higher-order oligomer: effective oligomerization is required for receptor maturation, surface delivery, and function.

    Juan F. Lopez-Gimenez;Meritxell Canals;John D. Pediani;Graeme Milligan

  • Adenosine A2A-dopamine D2 receptor-receptor heteromers. Targets for neuro-psychiatric disorders

    Sergi Ferré;Francisco Ciruela;Meritxell Canals;Daniel Marcellino

  • Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

    Nestor N. Jimenez-Vargas;Luke A. Pattison;Peishen Zhao;Tina Marie Lieu

  • Adenosine A2A Receptor and Dopamine D3 Receptor Interactions: Evidence of Functional A2A/D3 Heteromeric Complexes

    Maria Torvinen;Daniel Marcellino;Meritxell Canals;Luigi F. Agnati

  • Receptor heteromerization in adenosine A2A receptor signaling

    K. Fuxe;Luigi Francesco Agnati;K. Jacobsen;J. Hillion

  • Adenosine A 2A -Dopamine D 2 Receptor-Receptor Heteromerization

    Meritxell Canals;Daniel Marcellino;Francesca Fanelli;Francisco Ciruela

Frequent Co-Authors

Nigel W. Bunnett
Nigel W. Bunnett New York University
Arthur Christopoulos
Arthur Christopoulos Monash University
Sergi Ferré
Sergi Ferré National Institute on Drug Abuse
Rafael Franco
Rafael Franco University of Barcelona
Kjell Fuxe
Kjell Fuxe Karolinska Institute
Patrick M. Sexton
Patrick M. Sexton Monash University
Francisco Ciruela
Francisco Ciruela University of Barcelona
Carmen Lluis
Carmen Lluis University of Barcelona
Graeme Milligan
Graeme Milligan University of Glasgow
Amina S. Woods
Amina S. Woods National Institute on Drug Abuse

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