D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Chemistry D-index 43 Citations 8,308 270 World Ranking 11302 National Ranking 1492

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Gene
  • Organic chemistry

Weiliang Zhu mainly focuses on Computational chemistry, Drug discovery, Stereochemistry, Docking and Hydrogen bond. His study in Computational chemistry is interdisciplinary in nature, drawing from both Chemical physics, Intermolecular force, Ab initio quantum chemistry methods and Halogen. His Drug discovery research is multidisciplinary, incorporating perspectives in Virtual screening, Combinatorial chemistry, Computational biology, Data science and Receiver operating characteristic.

His Stereochemistry study incorporates themes from Chemical synthesis, Click chemistry, Molecular dynamics and Rational design. His Docking study combines topics from a wide range of disciplines, such as Virology, DOCK, DNA, In silico and Binding site. His Hydrogen bond study necessitates a more in-depth grasp of Molecule.

His most cited work include:

  • Predicting protein-protein interactions based only on sequences information. (599 citations)
  • Halogen bonding--a novel interaction for rational drug design? (436 citations)
  • TarFisDock: a web server for identifying drug targets with docking approach (264 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of study are Stereochemistry, Computational chemistry, Molecular dynamics, Hydrogen bond and Biochemistry. His Stereochemistry study combines topics in areas such as Receptor and Structure–activity relationship. His Computational chemistry research includes elements of Crystallography, Ab initio, Molecule and Halogen bond.

His Crystallography research integrates issues from Ring and Halogen. His study looks at the intersection of Molecular dynamics and topics like Biophysics with Hydrophobic effect. His work carried out in the field of Hydrogen bond brings together such families of science as Inorganic chemistry and Intermolecular force.

He most often published in these fields:

  • Stereochemistry (20.05%)
  • Computational chemistry (19.26%)
  • Molecular dynamics (14.78%)

What were the highlights of his more recent work (between 2018-2021)?

  • Stereochemistry (20.05%)
  • Molecular dynamics (14.78%)
  • Cancer research (8.18%)

In recent papers he was focusing on the following fields of study:

Weiliang Zhu spends much of his time researching Stereochemistry, Molecular dynamics, Cancer research, Apoptosis and Cell growth. His Stereochemistry research integrates issues from Inhibitory postsynaptic potential, Ic50 values and Nitric oxide. His studies deal with areas such as Biophysics, Conformational change, Protein folding, Native structure and Hydrogen bond as well as Molecular dynamics.

The study incorporates disciplines such as Plasma protein binding, van der Waals force and Hydrophobic effect in addition to Biophysics. His Cancer research study incorporates themes from Protein kinase B, Diffuse large B-cell lymphoma, Viability assay, Cell cycle and PI3K/AKT/mTOR pathway. His Moiety study combines topics from a wide range of disciplines, such as IC50 and Biochemistry.

Between 2018 and 2021, his most popular works were:

  • Nelfinavir was predicted to be a potential inhibitor of 2019-nCov main protease by an integrative approach combining homology modelling, molecular docking and binding free energy calculation (123 citations)
  • Molecular Mechanism of Binding Selectivity of Inhibitors toward BACE1 and BACE2 Revealed by Multiple Short Molecular Dynamics Simulations and Free-Energy Predictions. (28 citations)
  • D3Targets-2019-nCoV: a webserver for predicting drug targets and for multi-target and multi-site based virtual screening against COVID-19. (24 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • Organic chemistry

His main research concerns Molecular dynamics, Stereochemistry, Biophysics, Pharmacology and Moiety. His biological study spans a wide range of topics, including Ligand, Benzamidine, Druggability, Receptor–ligand kinetics and Binding selectivity. His Stereochemistry research incorporates themes from Drug target, Protease, Small molecule and Homology.

In the field of Biophysics, his study on Conformational change overlaps with subjects such as Closed state. His research integrates issues of cGMP-specific phosphodiesterase type 5, Potency and Clinical trial in his study of Pharmacology. Weiliang Zhu interconnects Isatis tinctoria, Glycoside, Inhibitory postsynaptic potential, Nitric oxide and Ic50 values in the investigation of issues within Moiety.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Predicting protein-protein interactions based only on sequences information.

Juwen Shen;Jian Zhang;Xiaomin Luo;Weiliang Zhu.
Proceedings of the National Academy of Sciences of the United States of America (2007)

839 Citations

Halogen bonding--a novel interaction for rational drug design?

Yunxiang Lu;Ting Shi;Yong Wang;Huaiyu Yang.
Journal of Medicinal Chemistry (2009)

670 Citations

TarFisDock: a web server for identifying drug targets with docking approach

Honglin Li;Zhenting Gao;Ling Kang;Hailei Zhang.
Nucleic Acids Research (2006)

404 Citations

Nonbonding interactions of organic halogens in biological systems: implications for drug discovery and biomolecular design

Yunxiang Lu;Yong Wang;Weiliang Zhu.
Physical Chemistry Chemical Physics (2010)

400 Citations

PDTD: a web-accessible protein database for drug target identification

Zhenting Gao;Zhenting Gao;Honglin Li;Honglin Li;Hailei Zhang;Xiaofeng Liu.
BMC Bioinformatics (2008)

321 Citations

Conformational transition of amyloid β-peptide

Yechun Xu;Jianhua Shen;Xiaomin Luo;Weiliang Zhu.
Proceedings of the National Academy of Sciences of the United States of America (2005)

307 Citations

Halogen bonding for rational drug design and new drug discovery

Yunxiang Lu;Yingtao Liu;Zhijian Xu;Haiying Li.
Expert Opinion on Drug Discovery (2012)

220 Citations

Halogen bond: its role beyond drug-target binding affinity for drug discovery and development.

Zhijian Xu;Zhuo Yang;Yingtao Liu;Yunxiang Lu.
Journal of Chemical Information and Modeling (2014)

209 Citations

Binding interaction of quercetin-3-β-galactoside and its synthetic derivatives with SARS-CoV 3CLpro: Structure–activity relationship studies reveal salient pharmacophore features

Lili Chen;Jian Li;Cheng Luo;Hong Liu.
Bioorganic & Medicinal Chemistry (2006)

186 Citations

Nelfinavir was predicted to be a potential inhibitor of 2019-nCov main protease by an integrative approach combining homology modelling, molecular docking and binding free energy calculation

Xu Z;Peng C;Shi Y;Zhu Z.
bioRxiv (2020)

177 Citations

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