Xu Shen

Overview

Best Publications

• Binding interaction of quercetin-3-β-galactoside and its synthetic derivatives with SARS-CoV 3CLpro: Structure–activity relationship studies reveal salient pharmacophore features

  Lili Chen;Jian Li;Cheng Luo;Hong Liu

  314
  Citations

• Cinanserin Is an Inhibitor of the 3C-Like Proteinase of Severe Acute Respiratory Syndrome Coronavirus and Strongly Reduces Virus Replication In Vitro

  Lili Chen;Chunshan Gui;Xiaomin Luo;Qingang Yang

  243
  Citations

• d-Alanine:d-alanine ligase as a new target for the flavonoids quercetin and apigenin

  Dalei Wu;Yunhua Kong;Cong Han;Jing Chen

  240
  Citations

• Arctigenin Effectively Ameliorates Memory Impairment in Alzheimer's Disease Model Mice Targeting Both β-Amyloid Production and Clearance

  Zhiyuan Zhu;Jianming Yan;Wei Jiang;Xin-gang Yao

  231
  Citations

• pH-dependent conformational flexibility of the SARS-CoV main proteinase (M(pro)) dimer: molecular dynamics simulations and multiple X-ray structure analyses.

  Jinzhi Tan;Koen H.G. Verschueren;Kanchan Anand;Jianhua Shen

  207
  Citations

• In Silico Prediction of Chemical Acute Oral Toxicity Using Multi-Classification Methods

  Xiao Li;Lei Chen;Feixiong Cheng;Zengrui Wu

  198
  Citations

• Virtual Screening on Natural Products for Discovering Active Compounds and Target Information

  Jianhua Shen;Xiaoying Xu;Feng Cheng;Hong Liu

  191
  Citations

• Three flavonoids targeting the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: crystal structure characterization with enzymatic inhibition assay.

  Liang Zhang;Yunhua Kong;Dalei Wu;Haitao Zhang

  180
  Citations

• Association between cigarette smoking and Parkinson’s disease: A meta-analysis

  Xiao Li;Xiao Li;Weihua Li;Guixia Liu;Xu Shen

  171
  Citations

• Crystal structure of HAb18G/CD147: implications for immunoglobulin superfamily homophilic adhesion.

  Xiao-Ling Yu;Tiancen Hu;Jia-Mu Du;Jian-Ping Ding

  155
  Citations

• Structural and Functional Characterization of Falcipain-2, a Hemoglobinase from the Malarial Parasite Plasmodium falciparum.

  Tanis Hogg;Krishna Nagarajan;Saskia Herzberg;Lili Chen

  150
  Citations

• Nucleocapsid Protein of SARS Coronavirus Tightly Binds to Human Cyclophilin A

  Cheng Luo;Haibin Luo;Suxin Zheng;Chunshan Gui

  149
  Citations

• The nucleocapsid protein of SARS coronavirus has a high binding affinity to the human cellular heterogeneous nuclear ribonucleoprotein A1

  Haibin Luo;Qing Chen;Jing Chen;Kaixian Chen

  141
  Citations

• Structure-based discovery of inhibitors of the YycG histidine kinase: New chemical leads to combat Staphylococcus epidermidis infections

  Zhiqiang Qin;Jian Zhang;Bin Xu;Lili Chen

  134
  Citations

• Severe acute respiratory syndrome coronavirus 3C-like proteinase N terminus is indispensable for proteolytic activity but not for enzyme dimerization. Biochemical and thermodynamic investigation in conjunction with molecular dynamics simulations.

  Shuai Chen;Lili Chen;Jinzhi Tan;Jing Chen

  132
  Citations

• Identification of an epitope of SARS-coronavirus nucleocapsid protein

  Ying Lin;Xu Shen;Rui Fu Yang;Yi Xue Li

  126
  Citations

• Pseudolarix acid B, a new tubulin-binding agent, inhibits angiogenesis by interacting with a novel binding site on tubulin

  Yun-Guang Tong;Xiong-Wen Zhang;Mei-Yu Geng;Jian-Ming Yue

  120
  Citations

• Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation

  Jianhua Cai;Cong Han;Tiancen Hu;Jian Zhang

  115
  Citations

• A 3D model of SARS_CoV 3CL proteinase and its inhibitors design by virtual screening.

  Bin Xiong;Chun Shan Gui;Xiao Ying Xu;Cheng Luo

  112
  Citations

• Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.

  Shuaishuai Ni;Yaxia Yuan;Jin Huang;Xiaona Mao

  109
  Citations