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Chemistry

D-Index
51
Citations
9008
World Ranking
13977
National Ranking
2163

Overview

Lihong Hu is affiliated with the Chinese Academy of Sciences in China and has contributed extensively to the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their research focus spans several subfields including Molecular Biology, Organic Chemistry, Oncology, Pharmacology, and Immunology.

The scientist's work covers main topics such as Immune cells in cancer, Pharmacological Effects of Natural Compounds, Immune Cell Function and Interaction, Nanoparticle-Based Drug Delivery, HER2/EGFR in Cancer Research, Protein Degradation and Inhibitors, and Inflammasome and immune disorders.

Among their recent papers are:

  • "Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation" (2021, Acta Pharmaceutica Sinica B)
  • "Engineering Exosome-Like Nanovesicles Derived from Asparagus cochinchinensis Can Inhibit the Proliferation of Hepatocellular Carcinoma Cells with Better Safety Profile" (2021, International Journal of Nanomedicine)
  • "A new wave of innovations within the DNA damage response" (2023, Signal Transduction and Targeted Therapy)
  • "Didymin switches M1-like toward M2-like macrophage to ameliorate ulcerative colitis via fatty acid oxidation" (2021, Pharmacological Research)
  • "Resource, chemical structure and activity of natural polysaccharides against alcoholic liver damages" (2020, Carbohydrate Polymers)

Lihong Hu frequently collaborates with researchers including Yinan Zhang, Junwei Wang, Qi Lv, Xiachang Wang, and Di Kang.

The scientist has published multiple articles in journals such as the Journal of Medicinal Chemistry, Research Square, Bioorganic & Medicinal Chemistry Letters, SSRN Electronic Journal, and the European Journal of Medicinal Chemistry. The number of publications in these venues indicates an active involvement in medicinal chemistry and related biomedical research fields.

Best Publications

  • Ursolic acid and its derivative inhibit protein tyrosine phosphatase 1B, enhancing insulin receptor phosphorylation and stimulating glucose uptake

    Wei Zhang;Di Hong;Yueyang Zhou;Yinan Zhang

  • Identification of influenza A nucleoprotein as an antiviral target

    Richard Y Kao;Dan Yang;Lai-Shan Lau;Wayne H W Tsui

  • d-Alanine:d-alanine ligase as a new target for the flavonoids quercetin and apigenin

    Dalei Wu;Yunhua Kong;Cong Han;Jing Chen

  • Arctigenin Effectively Ameliorates Memory Impairment in Alzheimer's Disease Model Mice Targeting Both β-Amyloid Production and Clearance

    Zhiyuan Zhu;Jianming Yan;Wei Jiang;Xin-gang Yao

  • Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities.

    Yi-Nan Zhang;Wei Zhang;Di Hong;Lei Shi

  • Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation

    Qi Lv;Yao Xing;Jian Liu;Dong Dong

  • Engineering Exosome-Like Nanovesicles Derived from Asparagus cochinchinensis Can Inhibit the Proliferation of Hepatocellular Carcinoma Cells with Better Safety Profile.

    Lei Zhang;Fengjun He;Lina Gao;Minghui Cong

  • Identification of novel small-molecule inhibitors of severe acute respiratory syndrome-associated coronavirus by chemical genetics.

    Richard Y. Kao;Wayne H.W. Tsui;Terri S.W. Lee;Julian A. Tanner

  • Three flavonoids targeting the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: crystal structure characterization with enzymatic inhibition assay.

    Liang Zhang;Yunhua Kong;Dalei Wu;Haitao Zhang

  • Structure-activity relationships of flavonoids for vascular relaxation in porcine coronary artery

    Y.C. Xu;S.W.S. Leung;D.K.Y. Yeung;L.H. Hu

  • Thiamine hydrochloride (VB1): an efficient promoter for the one-pot synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine and [1,2,4]triazolo[1,5-a]pyrimidine derivatives in water medium

    Junhua Liu;Min Lei;Lihong Hu

  • Acetohydrazone: A Transient Directing Group for Arylation of Unactivated C(sp3)–H Bonds

    Fei Ma;Min Lei;Lihong Hu;Lihong Hu

  • A convenient one-pot synthesis of formamide derivatives using thiamine hydrochloride as a novel catalyst

    Min Lei;Lei Ma;Lihong Hu;Lihong Hu

  • Thiamine hydrochloride as a efficient catalyst for the synthesis of amidoalkyl naphthols

    Min Lei;Lei Ma;Lihong Hu;Lihong Hu

  • Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation.

    Lei Shi;Wei Zhang;Yue-Yang Zhou;Yi-Nan Zhang

  • Small molecules from natural sources, targeting signaling pathways in diabetes.

    Qiong Liu;Lili Chen;Lihong Hu;Yuewei Guo

  • An Approach to 3,6-Disubstituted 2,5-Dioxybenzoquinones via Two Sequential Suzuki Couplings. Three-Step Synthesis of Leucomelone

    Xianwen Gan;Wei Jiang;Wei Wang;Lihong Hu

  • 2,2′,4′‐Trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice

    Zhiyuan Zhu;Chenjing Li;Xu Wang;Zhengyi Yang

  • Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target

    Xiao-Yi Zeng;Hao Wang;Fang Bai;Xiu Zhou

  • A general strategy for diversifying complex natural products to polycyclic scaffolds with medium-sized rings.

    Changgui Zhao;Zhengqing Ye;Zhi-xiong Ma;Scott A. Wildman

  • Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle.

    Xu-bing Chen;Jing-jing Zhuang;Jun-hua Liu;Min Lei

  • Biochemical characterization and inhibitor discovery of shikimate dehydrogenase from Helicobacter pylori.

    Cong Han;Lirui Wang;Kunqian Yu;Lili Chen

  • Molecular determinants of magnolol targeting both RXRα and PPARγ.

    Haitao Zhang;Xing Xu;Lili Chen;Jing Chen

Frequent Co-Authors

Xu Shen
Xu Shen Nanjing University of Chinese Medicine
Hualiang Jiang
Hualiang Jiang Chinese Academy of Sciences
De-An Guo
De-An Guo Chinese Academy of Sciences
Xing Xu
Xing Xu Chinese Academy of Sciences
Vatcharin Rukachaisirikul
Vatcharin Rukachaisirikul Prince of Songkla University
Wei Wang
Wei Wang East China University of Science and Technology
Min Yang
Min Yang Chinese Academy of Sciences
Kaixian Chen
Kaixian Chen Chinese Academy of Sciences
David E. James
David E. James University of Sydney
Edward W. Kraegen
Edward W. Kraegen Garvan Institute of Medical Research

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