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Immunology

D-Index
80
Citations
39584
World Ranking
1596
National Ranking
136

Overview

Sergio A. Quezada is affiliated with University College London in the United Kingdom. Their research spans multiple interconnected fields within biomedical science, emphasizing oncology and immunology.

The main fields of study in Quezada's work include Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. Within these broader areas, Quezada focuses on several subfields, notably Oncology, Immunology, Molecular Biology, Cancer Research, and Pulmonary and Respiratory Medicine.

The scientist's research addresses various topics related to cancer and immune system interactions. Key topics include Cancer Immunotherapy and Biomarkers, Immunotherapy and Immune Responses, Cancer Genomics and Diagnostics, CAR-T Cell Therapy Research, Immune Cell Function and Interaction, Monoclonal and Polyclonal Antibodies Research, and T-cell and B-cell Immunology.

Quezada has contributed to numerous publications, with frequent appearances in several high-profile venues. The most common publication outlets are Cancer Research, Nature, Nature Cancer, bioRxiv (Cold Spring Harbor Laboratory), and Nature Communications.

Frequent collaborators in their work include Charles Swanton, James L. Reading, Teresa Marafioti, Crispin T. Hiley, and Mariam Jamal-Hanjani.

The scientist has published multiple recent research papers, such as:

  • Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition (2021, Cell)
  • Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion (2021, Cell)
  • Embracing cancer complexity: Hallmarks of systemic disease (2024, Cell)
  • Geospatial immune variability illuminates differential evolution of lung adenocarcinoma (2020, Nature Medicine)
  • Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma (2021, Nature Communications)

Best Publications

  • Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

    Nicholas McGranahan;Nicholas McGranahan;Andrew J. S. Furness;Rachel Rosenthal;Sofie Ramskov

  • Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic

    T.A. Chan;M. Yarchoan;E. Jaffee;C. Swanton

  • Tracking the Evolution of Non–Small-Cell Lung Cancer

    Mariam Jamal-Hanjani;Gareth A. Wilson;Nicholas McGranahan;Nicolai Juul Birkbak

  • Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

    Christopher Abbosh;Nicolai J. Birkbak;Nicolai J. Birkbak;Gareth A. Wilson;Gareth A. Wilson;Mariam Jamal-Hanjani

  • Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.

    Tyler R. Simpson;Fubin Li;Welby Montalvo-Ortiz;Manuel A. Sepulveda

  • Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution

    Nicholas McGranahan;Rachel Rosenthal;Crispin T. Hiley;Crispin T. Hiley;Andrew J. Rowan

  • Cutting Edge: Contact-Mediated Suppression by CD4+CD25+ Regulatory Cells Involves a Granzyme B-Dependent, Perforin-Independent Mechanism

    David C. Gondek;Li-Fan Lu;Sergio A. Quezada;Shimon Sakaguchi

  • Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies

    Karl S. Peggs;Sergio A. Quezada;Cynthia A. Chambers;Alan J. Korman

  • Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

    Santiago Zelenay;Annemarthe G. van der Veen;Jan P. Böttcher;Kathryn J. Snelgrove

  • Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

    Sergio A. Quezada;Tyler R. Simpson;Karl S. Peggs;Taha Merghoub

  • Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis

    Samra Turajlic;Samra Turajlic;Kevin Litchfield;Hang Xu;Rachel Rosenthal

  • Neoantigen-directed immune escape in lung cancer evolution

    Rachel Rosenthal;Rachel Rosenthal;Elizabeth Larose Cadieux;Roberto Salgado;Maise Al Bakir

  • CD40/CD154 interactions at the interface of tolerance and immunity

    Sergio A. Quezada;Lamis Z. Jarvinen;Evan F. Lind;Randolph J. Noelle

  • Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition

    Kevin Litchfield;Kevin Litchfield;James L. Reading;Clare Puttick;Krupa Thakkar;Krupa Thakkar

  • CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells

    Sergio A. Quezada;Karl S. Peggs;Michael A. Curran;James P. Allison

  • Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies

    Frederick Arce Vargas;Andrew J S Furness;Kevin Litchfield;Kroopa Joshi

  • Principles and use of anti-CTLA4 antibody in human cancer immunotherapy.

    Karl S Peggs;Sergio A Quezada;Alan J Korman;James P Allison

  • Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors.

    Frederick Arce Vargas;Andrew J.S. Furness;Andrew J.S. Furness;Isabelle Solomon;Kroopa Joshi;Kroopa Joshi

  • A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapy.

    Brian Philip;Evangelia Kokalaki;Leila Mekkaoui;Simon Thomas

  • Translational Implications of Tumor Heterogeneity

    Mariam Jamal-Hanjani;Sergio A. Quezada;James Larkin;Charles Swanton

  • Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade

    Adel Samson;Karen J. Scott;David Taggart;Emma J. West

  • Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes

    Amalie Kai Bentzen;Andrea Marion Marquard;Rikke Lyngaa;Sunil Kumar Saini

Frequent Co-Authors

Charles Swanton
Charles Swanton The Francis Crick Institute
Karl S. Peggs
Karl S. Peggs University College London
Javier Herrero
Javier Herrero University College London
James P. Allison
James P. Allison The University of Texas MD Anderson Cancer Center
James Larkin
James Larkin Royal Marsden NHS Foundation Trust
Allan Hackshaw
Allan Hackshaw University College London
Randolph J. Noelle
Randolph J. Noelle Dartmouth College
Peter Van Loo
Peter Van Loo The Francis Crick Institute
Zoltan Szallasi
Zoltan Szallasi Boston Children's Hospital
Caroline Dive
Caroline Dive University of Manchester

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