World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
89
Citations
37939
World Ranking
1101
National Ranking
96

Medicine

D-Index
89
Citations
37975
World Ranking
12496
National Ranking
1177

Overview

Karl S. Peggs is affiliated with University College London in the United Kingdom. Their research primarily focuses on the field of Medicine, with a strong concentration on Oncology and Immunology. They contribute extensively to subfields such as Epidemiology, Hematology, and Public Health, Environmental and Occupational Health.

The main topics covered in their work include:

  • CAR-T cell therapy research
  • Immune Cell Function and Interaction
  • Cytomegalovirus and herpesvirus research
  • Cancer Immunotherapy and Biomarkers
  • Immunotherapy and Immune Responses
  • Hematopoietic Stem Cell Transplantation
  • Acute Lymphoblastic Leukemia research

Their publication record features numerous papers in leading scientific venues. Frequent publication venues include:

  • Blood
  • Nature
  • Nature Cancer
  • Immunity
  • Journal of Clinical Oncology

Some of their recent papers are:

  • The evolution of lung cancer and impact of subclonal selection in TRACERx, 2023, Nature
  • Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells, 2020, Immunity
  • The evolution of non-small cell lung cancer metastases in TRACERx, 2023, Nature
  • CD25-Treg-depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunity, 2020, Nature Cancer
  • Durable Responses and Low Toxicity After Fast Off-Rate CD19 Chimeric Antigen Receptor-T Therapy in Adults With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia, 2021, Journal of Clinical Oncology

Karl S. Peggs has collaborated frequently with several researchers, including:

  • Claire Roddie
  • Sergio A. Quezada
  • Maria A. V. Marzolini
  • Maeve O'Reilly
  • Martin Pulé

Best Publications

  • Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

    Nicholas McGranahan;Nicholas McGranahan;Andrew J. S. Furness;Rachel Rosenthal;Sofie Ramskov

  • ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells

    Daniel W. Lee;Bianca D. Santomasso;Frederick L. Locke;Armin Ghobadi

  • Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

    Christopher Abbosh;Nicolai J. Birkbak;Nicolai J. Birkbak;Gareth A. Wilson;Gareth A. Wilson;Mariam Jamal-Hanjani

  • Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.

    Tyler R. Simpson;Fubin Li;Welby Montalvo-Ortiz;Manuel A. Sepulveda

  • Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies

    Karl S. Peggs;Sergio A. Quezada;Cynthia A. Chambers;Alan J. Korman

  • Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

    Sergio A. Quezada;Tyler R. Simpson;Karl S. Peggs;Taha Merghoub

  • Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells

    Waseem Qasim;Hong Zhan;Sujith Samarasinghe;Stuart Adams

  • Multiplex Genome-Edited T-cell Manufacturing Platform for “Off-the-Shelf” Adoptive T-cell Immunotherapies

    Laurent Poirot;Brian Philip;Cécile Schiffer-Mannioui;Diane Le Clerre

  • Checkpoint blockade in cancer immunotherapy

    Alan J. Korman;Karl S. Peggs;James P. Allison

  • CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells

    Sergio A. Quezada;Karl S. Peggs;Michael A. Curran;James P. Allison

  • In vivo CAMPATH-1H prevents graft-versus-host disease following nonmyeloablative stem cell transplantation.

    Panagiotis D Kottaridis;Donald W Milligan;Rajesh Chopra;Ronjon Chakraverty

  • Adoptive cellular therapy for early cytomegalovirus infection after allogeneic stem-cell transplantation with virus-specific T-cell lines.

    Karl S Peggs;Stephanie Verfuerth;Arnold Pizzey;Naeem Khan

  • Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies

    Frederick Arce Vargas;Andrew J S Furness;Kevin Litchfield;Kroopa Joshi

  • Principles and use of anti-CTLA4 antibody in human cancer immunotherapy.

    Karl S Peggs;Sergio A Quezada;Alan J Korman;James P Allison

  • Epitope Landscape in Breast and Colorectal Cancer

    Neil H. Segal;D. Williams Parsons;Karl S. Peggs;Victor Velculescu

  • Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors.

    Frederick Arce Vargas;Andrew J.S. Furness;Andrew J.S. Furness;Isabelle Solomon;Kroopa Joshi;Kroopa Joshi

  • A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapy.

    Brian Philip;Evangelia Kokalaki;Leila Mekkaoui;Simon Thomas

  • High incidence of cytomegalovirus infection after nonmyeloablative stem cell transplantation: potential role of Campath-1H in delaying immune reconstitution.

    Suparno Chakrabarti;Stephen Mackinnon;Rajesh Chopra;Panagiotis D Kottaridis

  • Limiting transplantation-related mortality following unrelated donor stem cell transplantation by using a nonmyeloablative conditioning regimen

    Ronjon Chakraverty;Karl S Peggs;Rajesh Chopra;Donald W Milligan

  • Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA

    Unknown

  • Clinical evidence of a graft-versus-Hodgkin's-lymphoma effect after reduced-intensity allogeneic transplantation.

    Karl S Peggs;Ann Hunter;Rajesh Chopra;Anne Parker

Frequent Co-Authors

David C. Linch
David C. Linch University College London
Emma Morris
Emma Morris University College London
Sergio A. Quezada
Sergio A. Quezada University College London
Anthony H. Goldstone
Anthony H. Goldstone University College Hospital
Charles Swanton
Charles Swanton The Francis Crick Institute
Donald Milligan
Donald Milligan University of Birmingham
Nigel H. Russell
Nigel H. Russell University of Nottingham
Charles Craddock
Charles Craddock Queen Elizabeth Hospital Birmingham
Nicholas McGranahan
Nicholas McGranahan University College London
Benjamin M. Chain
Benjamin M. Chain University College London

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Related Online Degrees & Career Pathways

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