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Microbiology

D-Index
71
Citations
17144
World Ranking
1858
National Ranking
155

Overview

Benjamin M. Chain is affiliated with University College London in the United Kingdom. Their research has concentrated extensively on immunology, infectious diseases, molecular biology, and oncology, particularly emphasizing T-cell and B-cell immunology and COVID-19 related studies.

The scientist has published numerous papers across several prominent venues. Frequent publication platforms include bioRxiv (Cold Spring Harbor Laboratory), Frontiers in Immunology, Nature, eLife, and Cancer Research. These venues reflect their engagement with cutting-edge research communities in medicine and biomedical science.

Main fields of study for Benjamin M. Chain encompass Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. Within these fields, their subfields of study highlight Immunology, Molecular Biology, Infectious Diseases, Oncology, and Radiology, Nuclear Medicine and Imaging.

Key topics addressed in their research include the following:

  • T-cell and B-cell Immunology
  • SARS-CoV-2 and COVID-19 Research
  • Immune Cell Function and Interaction
  • COVID-19 Clinical Research Studies
  • Cancer Immunotherapy and Biomarkers
  • Vaccines and Immunoinformatics Approaches
  • Monoclonal and Polyclonal Antibodies Research

Benjamin M. Chain has collaborated extensively with several frequent co-authors, contributing to a network of research in immunology and related domains. Notable collaborators include Mahdad Noursadeghi, Sergio A. Quezada, James L. Reading, Joshua Rosenheim, and Daniel M. Altmann.

Their recent publications reflect a strong focus on immune responses in SARS-CoV-2 and cancer immunotherapy, exemplified by several influential papers:

  • "Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2," 2021, Nature
  • "Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose," 2021, Science
  • "Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma," 2021, Cancer Cell
  • "Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection," 2020, Science Immunology
  • "An immunodominant NP105-113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease," 2021, Nature Immunology

Best Publications

  • The sequence of sequencers: The history of sequencing DNA.

    James M. Heather;Benjamin Chain

  • Neoantigen-directed immune escape in lung cancer evolution

    Rachel Rosenthal;Rachel Rosenthal;Elizabeth Larose Cadieux;Roberto Salgado;Maise Al Bakir

  • Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure

    Unknown

  • Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2.

    Leo Swadling;Mariana O. Diniz;Nathalie M. Schmidt;Oliver E. Amin

  • Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose.

    Catherine J. Reynolds;Corinna Pade;Joseph M. Gibbons;David K. Butler

  • Hypochlorous Acid: A Natural Adjuvant That Facilitates Antigen Processing, Cross-Priming, and the Induction of Adaptive Immunity

    Zofia M. Prokopowicz;Frederick Arce;Rafal Biedron;Cheryl L.-L. Chiang

  • Dengue Virus NS5 Inhibits Interferon-α Signaling by Blocking Signal Transducer and Activator of Transcription 2 Phosphorylation

    Michela Mazzon;Meleri Jones;Andrew Davidson;Benjamin Chain

  • Antigen processing for presentation by class II major histocompatibility complex requires cleavage by cathepsin E.

    Bennett K;Levine T;Ellis Js;Peanasky Rj

  • Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma

    Lewis Au;Lewis Au;Emine Hatipoglu;Emine Hatipoglu;Marc Robert de Massy;Kevin Litchfield

  • Reactive oxygen species activate human peripheral blood dendritic cells.

    Karine Rutault;Charles Alderman;Benjamin M. Chain;David R. Katz

  • Quantitative imaging assay for NF-κB nuclear translocation in primary human macrophages

    Mahdad Noursadeghi;Jhen Tsang;Thomas Haustein;Robert F. Miller

  • Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection.

    Catherine J. Reynolds;Leo Swadling;Joseph M. Gibbons;Corinna Pade

  • Nitric oxide up‐regulates the release of inflammatory mediators by mouse macrophages

    Janusz Marcinkiewicz;Agnieszka Grabowska;Benjamin Chain

  • T-cell receptor repertoires share a restricted set of public and abundant CDR3 sequences that are associated with self-related immunity

    Asaf Madi;Eric Shifrut;Shlomit Reich-Zeliger;Hilah Gal

  • The antigen-presenting environment in normal and human papillomavirus (HPV)-related premalignant cervical epithelium

    F. Mota;N. Rayment;S. Chong;A. Singer

  • Understanding HSV-1 entry glycoproteins

    Adi Reske;Gabriele Pollara;Claude Krummenacher;Benjamin M. Chain

  • Deletion of the virion host shutoff protein (vhs) from herpes simplex virus (HSV) relieves the viral block to dendritic cell activation: potential of vhs- HSV vectors for dendritic cell-mediated immunotherapy.

    Laila Samady;Emanuela Costigliola;Luci MacCormac;Yvonne McGrath

  • Effects of oxidised low density lipoprotein on dendritic cells: a possible immunoregulatory component of the atherogenic micro-environment?

    Charles J.J Alderman;Peter R Bunyard;Benjamin M Chain;John C Foreman

  • The injured cell: the role of the dendritic cell system as a sentinel receptor pathway.

    Mohammad A.A. Ibrahim;Benjamin M. Chain;David R. Katz

  • The role of advanced oxidation protein products in regulation of dendritic cell function.

    Charles J.J Alderman;Sachit Shah;John C Foreman;Benjamin M Chain

  • An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease

    Yanchun Peng;Suet Ling Felce;Danning Dong;Danning Dong;Frank Penkava

  • The functional interactions between CD98, β1-integrins, and CD147 in the induction of U937 homotypic aggregation

    Jae Youl Cho;David A. Fox;Vaclav Horejsi;Kimitaka Sagawa

Frequent Co-Authors

David R. Katz
David R. Katz University College London
Mahdad Noursadeghi
Mahdad Noursadeghi University College London
James C. Moon
James C. Moon University College London
Robert F. Miller
Robert F. Miller University College London
Robert S. Coffin
Robert S. Coffin University College London
Jae Youl Cho
Jae Youl Cho Sungkyunkwan University
Charles Swanton
Charles Swanton The Francis Crick Institute
Karl S. Peggs
Karl S. Peggs University College London
Mala K. Maini
Mala K. Maini University College London
Áine McKnight
Áine McKnight Queen Mary University of London

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