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Overview

Robert S. Coffin is affiliated with University College London in the United Kingdom. Their research encompasses multiple domains within biomedical science, particularly focusing on the interface of virology, immunology, and oncology.

Their recent publications highlight work on oncolytic herpes simplex virus therapies combined with immune checkpoint inhibitors, reflecting a focus on cancer immunotherapy. Notable papers include:

  • Combining BRAF inhibition with oncolytic herpes simplex virus enhances the immune-mediated antitumor therapy of BRAF-mutant thyroid cancer, 2020, Journal for ImmunoTherapy of Cancer
  • An open-label, single-arm, phase II clinical trial of RP1, an enhanced potency oncolytic herpes virus, combined with nivolumab in four solid tumor types: Initial results from the skin cancer cohorts, 2020, Journal of Clinical Oncology
  • Updated results from the skin cancer cohorts from an ongoing phase 1/2 multicohort study of RP1, an enhanced potency oncolytic HSV, combined with nivolumab (IGNYTE), 2022, Journal of Clinical Oncology
  • RP1 Combined With Nivolumab in Advanced Anti-PD-1-Failed Melanoma (IGNYTE), 2025, Journal of Clinical Oncology
  • Society for Immunotherapy of Cancer (SITC) recommendations on intratumoral immunotherapy clinical trials (IICT): from premalignant to metastatic disease, 2024, Journal for ImmunoTherapy of Cancer

Coffin frequently collaborates with researchers including Praveen K. Bommareddy, Kevin J. Harrington, Joseph J. Sacco, Mark R. Middleton, and Anna Olsson-Brown. These co-authorships indicate active engagement in clinical and translational immunotherapy studies.

Their works are often published in venues such as:

  • Regular and Young Investigator Award Abstracts
  • Journal of Clinical Oncology
  • Cancer Research
  • Journal for ImmunoTherapy of Cancer

The main fields of study contributing to Coffin's research are:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine
  • Immunology and Microbiology

Within these broader domains, Coffin's subfields of study include:

  • Oncology
  • Genetics
  • Immunology
  • Biotechnology
  • Epidemiology

The principal topics covered by their research involve:

  • Virus-based gene therapy research
  • CAR-T cell therapy research
  • Immunotherapy and Immune Responses
  • Cancer Research and Treatments
  • Cancer Immunotherapy and Biomarkers
  • Herpesvirus Infections and Treatments
  • Interferon and immune responses

Best Publications

  • ICP34.5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, and anti-tumour properties.

    Liu Bl;Robinson M;Han Zq;Branston Rh

  • A Phase I Study of OncoVEXGM-CSF, a Second-Generation Oncolytic Herpes Simplex Virus Expressing Granulocyte Macrophage Colony-Stimulating Factor

    Jennifer C.C. Hu;Robert S. Coffin;Ceri J. Davis;Nicola J. Graham

  • Phase I/II study of oncolytic HSV GM-CSF in combination with radiotherapy and cisplatin in untreated stage III/IV squamous cell cancer of the head and neck.

    Kevin J. Harrington;Mohan Hingorani;Mary Anne Tanay;Jennifer Hickey

  • Protection of Neuronal Cells from Apoptosis by Hsp27 Delivered with a Herpes Simplex Virus-based Vector

    Marcus J.D. Wagstaff;Yollanda Collaço-Moraes;Yollanda Collaço-Moraes;Jill Smith;Jaqueline S. de Belleroche

  • The Nogo receptor, its ligands and axonal regeneration in the spinal cord; a review.

    D. Hunt;R.S. Coffin;P.N. Anderson

  • Development and Optimization of Herpes Simplex Virus Vectors for Multiple Long-Term Gene Delivery to the Peripheral Nervous System

    J. A. Palmer;R. H. Branston;C. E. Lilley;M. J. Robinson

  • Heat shock proteins delivered with a virus vector can protect cardiac cells against apoptosis as well as against thermal or hypoxic stress.

    B.K. Brar;A. Stephanou;M.J.D. Wagstaff;R.S. Coffin

  • Multiple immediate-early gene-deficient herpes simplex virus vectors allowing efficient gene delivery to neurons in culture and widespread gene delivery to the central nervous system in vivo.

    Caroline E. Lilley;Filitsa Groutsi;ZiQun Han;James A. Palmer

  • Deletion of the virion host shutoff protein (vhs) from herpes simplex virus (HSV) relieves the viral block to dendritic cell activation: potential of vhs- HSV vectors for dendritic cell-mediated immunotherapy.

    Laila Samady;Emanuela Costigliola;Luci MacCormac;Yvonne McGrath

  • Hepatocyte growth factor promotes endogenous repair and functional recovery after spinal cord injury.

    Kazuya Kitamura;Akio Iwanami;Masaya Nakamura;Junichi Yamane

  • Bcl-2 Transcription from the Proximal P2 Promoter Is Activated in Neuronal Cells by the Brn-3a POU Family Transcription Factor

    Martin D. Smith;Elizabeth A. Ensor;Robert S. Coffin;Linda M. Boxer

  • Novel therapeutic strategy for stroke in rats by bone marrow stromal cells and ex vivo HGF gene transfer with HSV-1 vector.

    Ming Zhu Zhao;Naosuke Nonoguchi;Naokado Ikeda;Takuji Watanabe

  • Nogo Receptor mRNA Expression in Intact and Regenerating CNS Neurons

    David Hunt;M.R.J. Mason;G. Campbell;R. Coffin

  • Herpes Simplex Virus Infection of Dendritic Cells: Balance among Activation, Inhibition, and Immunity

    Gabriele Pollara;Katharina Speidel;Laila Samady;Mansi Rajpopat

  • Bone marrow stromal cells that enhanced fibroblast growth factor-2 secretion by herpes simplex virus vector improve neurological outcome after transient focal cerebral ischemia in rats

    Naokado Ikeda;Naosuke Nonoguchi;Ming Zhu Zhao;Takuji Watanabe

  • White paper on microbial anti-cancer therapy and prevention.

    Neil S. Forbes;Robert S. Coffin;Liang Deng;Laura Evgin

  • Nogo-A expression in the intact and injured nervous system.

    David Hunt;R.S Coffin;R.K Prinjha;G Campbell

  • In vivo myocardial gene transfer: optimization, evaluation and direct comparison of gene transfer vectors.

    M J Wright;L M L Wightman;C Lilley;M de Alwis

  • Infection of mature dendritic cells with herpes simplex virus type 1 dramatically reduces lymphoid chemokine-mediated migration

    Alexander T. Prechtel;Nadine M. Turza;Dieter J. Kobelt;Jutta I. Eisemann

  • Herpes simplex virus type-1-induced activation of myeloid dendritic cells: the roles of virus cell interaction and paracrine type I IFN secretion.

    Gabriele Pollara;Meleri Jones;Matthew E. Handley;Mansi Rajpopat

Frequent Co-Authors

Benjamin M. Chain
Benjamin M. Chain University College London
David R. Katz
David R. Katz University College London
Alexander Steinkasserer
Alexander Steinkasserer University of Erlangen-Nuremberg
Richard G. Vile
Richard G. Vile Mayo Clinic

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