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Konstantin G. Kousoulas

Konstantin G. Kousoulas

D-Index & Metrics

Microbiology

D-Index
53
Citations
7411
World Ranking
4150
National Ranking
1608

Research.com Recognitions

  • 2020 - Fellow, National Academy of Inventors

Overview

Konstantin G. Kousoulas is affiliated with Louisiana State University in the United States and has contributed extensively to research in medicine and biochemistry, genetics, and molecular biology. Their work spans multiple fields with a focus on epidemiology, immunology, genetics, infectious diseases, and molecular biology.

The main research topics covered by Konstantin G. Kousoulas include:

  • Virus-based gene therapy research
  • Herpesvirus infections and treatments
  • SARS-CoV-2 and COVID-19 research
  • Immunotherapy and immune responses
  • CAR-T cell therapy research
  • Cancer research and treatments
  • Cytomegalovirus and herpesvirus research

Frequent co-authors in Kousoulas's publications include:

  • Vladimir N. Chouljenko
  • Brent Stanfield
  • Farhana Musarrat
  • Paul J. F. Rider
  • Rafiq Nabi

The scientist has published in multiple venues with the most frequent being:

  • Journal of Medical Virology
  • Viruses
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Frontiers in Immunology

Significant recent papers include:

  • The anti-HIV drug nelfinavir mesylate (Viracept) is a potent inhibitor of cell fusion caused by the SARSCoV-2 spike (S) glycoprotein warranting further evaluation as an antiviral against COVID-19 infections, 2020, Journal of Medical Virology
  • Activating transcription factor 6 protects against endothelial barrier dysfunction, 2022, Cellular Signalling
  • Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation, 2023, Frontiers in Immunology
  • Synthesis, inverse docking-assisted identification and in vitro biological characterization of Flavonol-based analogs of fisetin as c-Kit, CDK2 and mTOR inhibitors against melanoma and non-melanoma skin cancers, 2020, Bioorganic Chemistry
  • Two Sides to Every Story: Herpes Simplex Type-1 Viral Glycoproteins gB, gD, gH/gL, gK, and Cellular Receptors Function as Key Players in Membrane Fusion, 2021, Viruses

Konstantin G. Kousoulas was awarded the Fellow of the National Academy of Inventors in 2020, recognizing their contributions to scientific innovation.

Best Publications

  • Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism.

    K. Ganesh Kumar;James L. Trevaskis;Daniel D. Lam;Gregory M. Sutton

  • Anatomy of the herpes simplex virus 1 strain F glycoprotein B gene: primary sequence and predicted protein structure of the wild type and of monoclonal antibody-resistant mutants.

    P E Pellett;K G Kousoulas;L Pereira;B Roizman

  • Structures of and allelic diversity and relationships among the major outer membrane protein (ompA) genes of the four chlamydial species.

    B Kaltenboeck;K G Kousoulas;J Storz

  • Biological and Genetic Characterization of a Hemagglutinating Coronavirus Isolated From a Diarrhoeic Child

    X. M. Zhang;W. Herbst;K. G. Kousoulas;J. Storz

  • The anti-HIV drug nelfinavir mesylate (Viracept) is a potent inhibitor of cell fusion caused by the SARSCoV-2 spike (S) glycoprotein warranting further evaluation as an antiviral against COVID-19 infections.

    Farhana Musarrat;Vladimir Chouljenko;Achyut Dahal;Rafiq Nabi

  • Palmitoylation of the cysteine-rich endodomain of the SARS-coronavirus spike glycoprotein is important for spike-mediated cell fusion.

    Chad M. Petit;Vladimir N. Chouljenko;Arun Iyer;Robin Colgrove

  • Primary human herpesvirus 8 infection generates a broadly specific CD8(+) T-cell response to viral lytic cycle proteins

    Qiong J. Wang;Frank J. Jenkins;Lisa P. Jacobson;Lawrence A. Kingsley

  • Herpes simplex virus type 1 glycoprotein K is not essential for infectious virus production in actively replicating cells but is required for efficient envelopment and translocation of infectious virions from the cytoplasm to the extracellular space.

    Sukhanya Jayachandra;Abolghasem Baghian;Konstantin G. Kousoulas

  • Coronavirus and Pasteurella Infections in Bovine Shipping Fever Pneumonia and Evans' Criteria for Causation

    Johannes Storz;Xiaoqing Lin;Charles W. Purdy;Vladimir N. Chouljenko

  • Genetic Analysis of the Role of Herpes Simplex Virus Type 1 Glycoprotein K in Infectious Virus Production and Egress

    Timothy P. Foster;Konstantin G. Kousoulas

  • Comparison of genomic and predicted amino acid sequences of respiratory and enteric bovine coronaviruses isolated from the same animal with fatal shipping pneumonia.

    Vladimir N. Chouljenko;X. Q. Lin;J. Storz;Konstantin G. Kousoulas

  • Mutations affecting conformation or sequence of neutralizing epitopes identified by reactivity of viable plaques segregate from syn and ts domains of HSV-1(F) gB gene

    Konstantin G. Kousoulas;Philip E. Pellettt;Lenore Pereira;Bernard Roizman

  • An α-Helical Domain within the Carboxyl Terminus of Herpes Simplex Virus Type 1 (HSV-1) glycoprotein B (gB) is Associated with Cell Fusion and Resistance to Heparin Inhibition of Cell Fusion

    Timothy P. Foster;Jeff M. Melancon;Konstantin G. Kousoulas

  • The Herpes Simplex Virus Type 1 UL20 Protein Modulates Membrane Fusion Events during Cytoplasmic Virion Morphogenesis and Virus-Induced Cell Fusion

    Timothy P. Foster;Jeffrey M. Melancon;Joel D. Baines;Konstantin G. Kousoulas

  • Plasma Membrane Topology of Syncytial Domains of Herpes Simplex Virus Type 1 Glycoprotein K (gK): the UL20 Protein Enables Cell Surface Localization of gK but Not gK-Mediated Cell-to-Cell Fusion

    Timothy P. Foster;Xavier Alvarez;Konstantin G. Kousoulas

  • Domain structure of herpes simplex virus 1 glycoprotein B: neutralizing epitopes map in regions of continuous and discontinuous residues.

    Lenore Pereira;Mir Ali;Konstantin Kousoulas;Bin Huo

  • Efficient production of single-stranded DNA as long as 2 kb for sequencing of PCR-amplified DNA.

    B Kaltenboeck;J W Spatafora;X Zhang;K G Kousoulas

  • Truncation of the carboxy-terminal 28 amino acids of glycoprotein B specified by herpes simplex virus type 1 mutant amb1511-7 causes extensive cell fusion.

    Abolghasem Baghian;Li Huang;S. Newman;Sukhanya Jayachandra

  • A Recombinant Herpes Simplex Virus Type 1 Expressing Two Additional Copies of gK Is More Pathogenic than Wild-Type Virus in Two Different Strains of Mice

    Kevin R. Mott;Guey Chuen Perng;Yanira Osorio;Konstantin G. Kousoulas

  • Two-step polymerase chain reactions and restriction endonuclease analyses detect and differentiate ompA DNA of Chlamydia spp

    B Kaltenboeck;K G Kousoulas;J Storz

Frequent Co-Authors

Lenore Pereira
Lenore Pereira University of California, San Francisco
David I. Bernstein
David I. Bernstein University of Cincinnati
Bernhard Lüscher
Bernhard Lüscher RWTH Aachen University
Shile Huang
Shile Huang Louisiana State University Health Sciences Center Shreveport
Yoshiharu Matsuura
Yoshiharu Matsuura Osaka University
Lawrence A. Kingsley
Lawrence A. Kingsley University of Pittsburgh
Philip E. Pellett
Philip E. Pellett Wayne State University
David M. Knipe
David M. Knipe Harvard University
Joel D. Baines
Joel D. Baines Cornell University
Shou-Jiang Gao
Shou-Jiang Gao University of Pittsburgh

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