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Microbiology

D-Index
76
Citations
21414
World Ranking
1414
National Ranking
616

Overview

Richard Longnecker is affiliated with Northwestern University in the United States and focuses on research primarily within the field of Medicine. Their work spans several subfields including Epidemiology, Immunology, Oncology, Infectious Diseases, and Molecular Biology.

The main topics that characterize Longnecker's research encompass:

  • Herpesvirus Infections and Treatments
  • Cytomegalovirus and herpesvirus research
  • Viral-associated cancers and disorders
  • Interferon and immune responses
  • Lymphoma Diagnosis and Treatment
  • Viral gastroenteritis research and epidemiology
  • SARS-CoV-2 and COVID-19 Research

Among Longnecker's recent publications are the following:

  • The structural basis of herpesvirus entry, 2020, Nature Reviews Microbiology
  • Unique functional responses differentially map onto genetic subtypes of dopamine neurons, 2023, Nature Neuroscience
  • Rewiring of B cell receptor signaling by Epstein-Barr virus LMP2A, 2020, Proceedings of the National Academy of Sciences
  • Epstein-Barr Virus gH/gL and Kaposi's Sarcoma-Associated Herpesvirus gH/gL Bind to Different Sites on EphA2 To Trigger Fusion, 2020, Journal of Virology
  • ASC-dependent inflammasomes contribute to immunopathology and mortality in herpes simplex encephalitis, 2021, PLoS Pathogens

Longnecker frequently collaborates with several co-authors, most notably:

  • Qing Fan
  • Cooper K. Hayes
  • Sarah A. Connolly
  • Lynn W. Enquist
  • David A. Leib

The primary venues where Longnecker's work appears regularly include:

  • Journal of Virology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • mBio
  • UNC Libraries
  • Nature Reviews Microbiology

Best Publications

  • Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death.

    Sheila Henderson;Martin Rowe;Chris Gregory;Debbie Croom-Carter

  • Epstein-Barr Virus LMP2A Drives B Cell Development and Survival in the Absence of Normal B Cell Receptor Signals

    Robert G Caldwell;Joanna B Wilson;Steven J Anderson;Richard Longnecker

  • Herpesvirus entry: an update.

    Patricia G. Spear;Richard Longnecker

  • CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae.

    Alison E.M. Adams;Douglas I. Johnson;Douglas I. Johnson;Richard M. Longnecker;Barbara F. Sloat

  • Fusing structure and function: a structural view of the herpesvirus entry machinery

    Sarah A. Connolly;Julia O. Jackson;Theodore S. Jardetzky;Richard Longnecker

  • BTK/TEC KINASES REGULATE SUSTAINED INCREASES IN INTRACELLULAR CA2+ FOLLOWING B-CELL RECEPTOR ACTIVATION

    Anne Catherine Fluckiger;Zuomei Li;Roberta M. Kato;Matthew I. Wahl

  • Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases.

    Cheryl L. Miller;Anne L. Burkhardt;Jennifer H. Lee;Becky Stealey

  • An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking.

    Cheryl L. Miller;Jennifer H. Lee;Elliott Kieff;Richard Longnecker

  • In Vivo Behavior of Genetically Engineered Herpes Simplex Viruses R7017 and R7020: Construction and Evaluation in Rodents

    Bernard Meignier;Richard Longnecker;Bernard Roizman

  • The structural basis of herpesvirus entry.

    Sarah A. Connolly;Theodore S. Jardetzky;Richard Longnecker

  • The Immunoreceptor Tyrosine-Based Activation Motif of Epstein–Barr Virus LMP2A Is Essential for Blocking BCR-Mediated Signal Transduction☆

    Sara Fruehling;Richard Longnecker

  • Epstein-barr virus

    Richard M Longnecker;Elliott Kieff;Jeffrey I. Cohen

  • Structure of a trimeric variant of the Epstein-Barr virus glycoprotein B

    Marija Backovic;Richard Longnecker;Theodore S. Jardetzky;Theodore S. Jardetzky

  • Virulence of and establishment of latency by genetically engineered deletion mutants of herpes simplex virus I

    Bernard Meignier;Richard Longnecker;Penelope Mavromara-Nazos;Amy E. Sears

  • Epstein-Barr virus (EBV) LMP2A mediates B-lymphocyte survival through constitutive activation of the Ras/PI3K/Akt pathway.

    Toni Portis;Richard M Longnecker

  • A second Epstein-Barr virus membrane protein (LMP2) is expressed in latent infection and colocalizes with LMP1.

    Richard Longnecker;Elliott Kieff

  • Clustering of genes dispensable for growth in culture in the S component of the HSV-1 genome

    Richard Longnecker;Bernard Roizman

  • Herpes simplex virus 1 protein kinase is encoded by open reading frame US3 which is not essential for virus growth in cell culture.

    F C Purves;R M Longnecker;D P Leader;B Roizman

  • Generation of an inverting herpes simplex virus 1 mutant lacking the L-S junction a sequences, an origin of DNA synthesis, and several genes including those specifying glycoprotein E and the alpha 47 gene.

    R Longnecker;B Roizman

  • An Epstein-Barr virus protein associated with cell growth transformation interacts with a tyrosine kinase.

    Richard Longnecker;Brian Druker;Thomas M. Roberts;Elliott Kieff

Frequent Co-Authors

Theodore S. Jardetzky
Theodore S. Jardetzky Stanford University
Elliott Kieff
Elliott Kieff Harvard University
Bernard Roizman
Bernard Roizman University of Chicago
Leo I. Gordon
Leo I. Gordon Northwestern University
Patricia G. Spear
Patricia G. Spear Northwestern University
Stephen D. Miller
Stephen D. Miller Northwestern University
Nancy Raab-Traub
Nancy Raab-Traub University of North Carolina at Chapel Hill
Robert D. Nicholls
Robert D. Nicholls University of Pittsburgh
Kevin P. White
Kevin P. White National University of Singapore
Jianjun Cheng
Jianjun Cheng University of Illinois at Urbana-Champaign

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