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Medicine

D-Index
104
Citations
46628
World Ranking
6980
National Ranking
683

Overview

David C. Linch is affiliated with University College London in the United Kingdom. Their research primarily spans the field of Medicine, focusing on various subfields such as Oncology, Hematology, Molecular Biology, Genetics, and Pathology and Forensic Medicine.

The scientist's work covers a range of topics, including:

  • Acute Myeloid Leukemia Research
  • CAR-T cell therapy research
  • Lymphoma Diagnosis and Treatment
  • Acute Lymphoblastic Leukemia research
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Viral-associated cancers and disorders
  • Immune Cell Function and Interaction

David C. Linch has authored and co-authored numerous papers, with recent notable publications including:

  • Estimated impact of the COVID-19 pandemic on cancer services and excess 1-year mortality in people with cancer and multimorbidity: near real-time data on cancer care, cancer deaths and a population-based cohort study, 2020, BMJ Open
  • Estimating excess mortality in people with cancer and multimorbidity in the COVID-19 emergency, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • Durable Responses and Low Toxicity After Fast Off-Rate CD19 Chimeric Antigen Receptor-T Therapy in Adults With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia, 2021, Journal of Clinical Oncology
  • Dual targeting of CD19 and CD22 with Bicistronic CAR-T cells in Patients with Relapsed/Refractory Large B Cell Lymphoma, 2023, Blood
  • EZH2-Deficient T-cell Acute Lymphoblastic Leukemia Is Sensitized to CHK1 Inhibition through Enhanced Replication Stress, 2020, Cancer Discovery

Frequent collaborators include Rosemary E. Gale, Robert K. Hills, Martin Pulé, Claire Roddie, and Karl S. Peggs. These coauthors have worked together in various capacities on multiple studies and publications.

The venues where David C. Linch frequently publishes reflect their research focus, including:

  • Blood
  • British Journal of Haematology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Hematological Oncology

Best Publications

  • The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials.

    Panagiotis D. Kottaridis;Rosemary E. Gale;Marion E. Frew;Georgina Harrison

  • Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B

    Amit C. Nathwani;Edward G.D. Tuddenham;Savita Rangarajan;Cecilia Rosales

  • Salvage Regimens With Autologous Transplantation for Relapsed Large B-Cell Lymphoma in the Rituximab Era

    Christian Gisselbrecht;Bertram Glass;Nicolas Mounier;Devinder Singh Gill

  • Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

    Steven J. Howe;Marc R. Mansour;Kerstin Schwarzwaelder;Cynthia Bartholomae

  • Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial

    D C Linch;D Winfield;A H Goldstone;D Moir

  • The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia

    Rosemary E. Gale;Claire Green;Christopher Allen;Adam J. Mead

  • Assessment of Minimal Residual Disease in Standard-Risk AML.

    Adam Ivey;Robert Kerrin Hills;Michael A. Simpson;Jelena V. Jovanovic

  • Randomised trial of filgrastim-mobilised peripheral blood progenitor cell transplantation versus autologous bone-marrow transplantation in lymphoma patients

    N Schmitz;P Dreger;D.C Linch;A.H Goldstone

  • Risk of Second Malignancy After Hodgkin’s Disease in a Collaborative British Cohort: The Relation to Age at Treatment

    A J Swerdlow;J A Barber;G V Hudson;D Cunningham

  • Long-term effect of a watch and wait policy versus immediate systemic treatment for asymptomatic advanced-stage non-Hodgkin lymphoma: a randomised controlled trial.

    KM Ardeshna;P Smith;A Norton;BW Hancock

  • Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone in patients with newly diagnosed diffuse large B-cell non-Hodgkin lymphoma: a phase 3 comparison of dose intensification with 14-day versus 21-day cycles

    David Cunningham;Eliza A Hawkes;Andrew Jack;Wendi Qian

  • In vivo CAMPATH-1H prevents graft-versus-host disease following nonmyeloablative stem cell transplantation.

    Panagiotis D Kottaridis;Donald W Milligan;Rajesh Chopra;Ronjon Chakraverty

  • Acute myeloid leukaemia.

    Asim Khwaja;Magnus Bjorkholm;Rosemary E Gale;Ross L Levine

  • A monoclonal antibody reactive with normal and leukemic human myeloid progenitor cells

    James D. Griffin;David Linch;Kert Sabbath;Peter Larcom

  • Myocardial Infarction Mortality Risk After Treatment for Hodgkin Disease: A Collaborative British Cohort Study

    Anthony J. Swerdlow;Craig D. Higgins;Paul Smith;David Cunningham

  • Prognostic significance of BCL-2 expression and bcl-2 major breakpoint region rearrangement in diffuse large cell non-Hodgkin's lymphoma: a British National Lymphoma Investigation Study.

    ME Hill;KA MacLennan;DC Cunningham;B Vaughan Hudson

  • High incidence of cytomegalovirus infection after nonmyeloablative stem cell transplantation: potential role of Campath-1H in delaying immune reconstitution.

    Suparno Chakrabarti;Stephen Mackinnon;Rajesh Chopra;Panagiotis D Kottaridis

  • Rituximab versus a watch-and-wait approach in patients with advanced-stage, asymptomatic, non-bulky follicular lymphoma: an open-label randomised phase 3 trial

    Kirit M Ardeshna;Wendi Qian;Paul Smith;Nivette Braganca

  • Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibitors

    Panagiotis D. Kottaridis;Rosemary E. Gale;Rosemary E. Gale;Stephen E. Langabeer;Stephen E. Langabeer;Marion E. Frew;Marion E. Frew

  • FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia.

    Adam J. Mead;David C. Linch;Robert Kerrin Hills;Keith Wheatley

Frequent Co-Authors

Anthony H. Goldstone
Anthony H. Goldstone University College Hospital
Alan Kenneth Burnett
Alan Kenneth Burnett University of Glasgow
Robert Kerrin Hills
Robert Kerrin Hills University of Oxford
Karl S. Peggs
Karl S. Peggs University College London
Emma Morris
Emma Morris University College London
David Cunningham
David Cunningham Royal Marsden NHS Foundation Trust
Donald Milligan
Donald Milligan University of Birmingham
Peter Hoskin
Peter Hoskin University of Manchester
John Radford
John Radford University of Manchester
Claire N. Harrison
Claire N. Harrison Guy's and St Thomas' NHS Foundation Trust

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