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Medicine

D-Index
104
Citations
38198
World Ranking
7073
National Ranking
3720

Overview

David J. Lefer is affiliated with the Louisiana State University Health Sciences Center New Orleans in the United States. Their research spans medicine and biochemistry, genetics, and molecular biology, with a significant focus on cardiology and cardiovascular medicine, physiology, molecular biology, biochemistry, and pathology and forensic medicine.

The primary topics covered by their work include cardiovascular function and risk factors, sulfur compounds in biology, adipose tissue and metabolism, heart failure treatment and management, nitric oxide and endothelin effects, cardiac ischemia and reperfusion, and diet and metabolism studies.

Frequent coauthors collaborating with David J. Lefer are:

  • Traci Goodchild
  • Zhen Li
  • Thomas E. Sharp
  • Kyle B. LaPenna
  • Huijing Xia

They have published extensively in several venues, particularly:

  • Circulation Research
  • Circulation
  • The FASEB Journal
  • JACC Basic to Translational Science
  • Journal of the American Heart Association

Notable recent papers authored by David J. Lefer include:

  • Nonlethal Inhibition of Gut Microbial Trimethylamine N-oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure, 2020, Journal of the American Heart Association
  • Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase, 2020, Biochemical Pharmacology
  • Mitochondrial H 2 S Regulates BCAA Catabolism in Heart Failure, 2022, Circulation Research
  • Renal Denervation to Treat Heart Failure, 2020, Annual Review of Physiology
  • Novel Göttingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities, 2021, JACC Basic to Translational Science

Best Publications

  • The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.

    Yasuko Kureishi;Zhengyu Luo;Ichiro Shiojima;Ann Bialik

  • Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function

    John W. Elrod;John W. Calvert;Joanna Morrison;Jeannette E. Doeller

  • The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice.

    Orlando F. Bueno;Leon J. De Windt;Kevin M. Tymitz;Sandra A. Witt

  • Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver

    Mark R. Duranski;James J.M. Greer;Andre Dejam;Sathya Jaganmohan

  • Nitrate and nitrite in biology, nutrition and therapeutics

    Jon O Lundberg;Mark T Gladwin;Amrita Ahluwalia;Nigel Benjamin

  • Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium.

    Xin Liang Ma;Andrew S. Weyrich;David J. Lefer;Allan M. Lefer

  • Time course of endothelial dysfunction and myocardial injury during myocardial ischemia and reperfusion in the cat.

    Tsao Ps;Aoki N;Lefer Dj;Johnson G rd

  • Oxidative stress and cardiac disease

    David J Lefer;D.Neil Granger

  • Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer

    Sruti Shiva;Michael N. Sack;James J. Greer;Mark Duranski

  • In vivo neutralization of P-selectin protects feline heart and endothelium in myocardial ischemia and reperfusion injury.

    Andrew S. Weyrich;Xin Liang Ma;David J. Lefer;Kurt H. Albertine

  • The role of nitric oxide and cell adhesion molecules on the microcirculation in ischaemia-reperfusion

    Allan M. Lefer;David J. Lefer

  • Hydrogen Sulfide in Biochemistry and Medicine

    Benjamin Lee Predmore;David Joseph Lefer;Gabriel Gojon

  • Role of endothelial dysfunction in the pathogenesis of reperfusion injury after myocardial ischemia.

    Allan M. Lefer;Philip S. Tsao;David J. Lefer;Xin-Liang Ma

  • Emergence of Hydrogen Sulfide as an Endogenous Gaseous Signaling Molecule in Cardiovascular Disease

    David J. Polhemus;David J. Lefer

  • Guidelines for experimental models of myocardial ischemia and infarction.

    Merry L. Lindsey;Merry L. Lindsey;Roberto Bolli;John M. Canty;Xiao Jun Du

  • Simvastatin preserves the ischemic-reperfused myocardium in normocholesterolemic rat hearts.

    Allan M. Lefer;Barry Campbell;Yong-Kyoo Shin;Rosario Scalia

  • Pharmacology of the Endothelium in Ischemia-Reperfusion and Circulatory Shock

    Allan M. Lefer;David J. Lefer

  • Hydrogen sulfide attenuates hepatic ischemia-reperfusion injury: role of antioxidant and antiapoptotic signaling

    Saurabh Jha;John W. Calvert;Mark R. Duranski;Arun Ramachandran

  • Modulation of leukocyte–endothelial interactions by reactive metabolites of oxygen and nitrogen: relevance to ischemic heart disease

    Matthew B. Grisham;D.Neil Granger;David J. Lefer

  • Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury

    Nathan S. Bryan;John W. Calvert;John W. Elrod;Susheel Gundewar

Frequent Co-Authors

John W. Elrod
John W. Elrod Temple University
Christopher G. Kevil
Christopher G. Kevil Louisiana State University Health Sciences Center Shreveport
Rui Wang
Rui Wang York University
Ming Xian
Ming Xian Brown University
Roberto Bolli
Roberto Bolli University of Louisville
Douglas R. Seals
Douglas R. Seals University of Colorado Boulder
William A. Coetzee
William A. Coetzee New York University
Toyoaki Murohara
Toyoaki Murohara Nagoya University
Erhe Gao
Erhe Gao Temple University
Allan M. Lefer
Allan M. Lefer Thomas Jefferson University

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