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Claus Storgaard Sørensen

Claus Storgaard Sørensen

D-Index & Metrics

Molecular Biology

D-Index
47
Citations
10544
World Ranking
2729
National Ranking
16

Overview

Claus Storgaard Sørensen is affiliated with the University of Copenhagen in Denmark. Their research focuses primarily on the fields of Biochemistry, Genetics, and Molecular Biology, with substantial work in subfields including Molecular Biology, Oncology, Genetics, Cancer Research, and Immunology.

Their work spans several main research topics, emphasizing mechanisms and processes central to cellular biology and disease. These include DNA Repair Mechanisms, CRISPR and Genetic Engineering, Epigenetics and DNA Methylation, PARP inhibition in cancer therapy, BRCA gene mutations in cancer, Mitochondrial Function and Pathology, and RNA modifications and cancer.

Sørensen has published extensively, with frequent contributions appearing in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Clinical Investigation
  • Nature Communications
  • Cell Reports
  • Mutation research. Fundamental and molecular mechanisms of mutagenesis

Among their recent papers are:

  • Histone H4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes, 2021, Nature Communications
  • WEE1 kinase limits CDK activities to safeguard DNA replication and mitotic entry, 2020, Mutation research. Fundamental and molecular mechanisms of mutagenesis
  • Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress, 2022, Science
  • WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity, 2022, Cell Reports
  • DNA binding and RAD51 engagement by the BRCA2 C-terminus orchestrate DNA repair and replication fork preservation, 2023, Nature Communications

Their frequent coauthors include Jan Benada, Valdemaras Petrosius, Maria Rossing, Muthiah Bose, and Muhammad Shoaib. These collaborations represent ongoing partnerships contributing to the body of work produced under Sørensen's research efforts.

Best Publications

  • The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

    Claus Storgaard Sørensen;Lasse Tengbjerg Hansen;Jaroslaw Dziegielewski;Randi G. Syljuåsen

  • Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A

    Claus Storgaard Sørensen;Randi G. Syljuåsen;Jacob Falck;Tine Schroeder

  • Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage.

    Randi G. Syljuåsen;Claus Storgaard Sørensen;Lasse Tengbjerg Hansen;Kasper Fugger

  • Phosphorylation of mammalian CDC6 by Cyclin A/CDK2 regulates its subcellular localization

    Birgit Otzen Petersen;Jiri Lukas;Claus Storgaard Sørensen;Jiri Bartek

  • Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation.

    Magtouf Gatei;Katie Sloper;Claus Sörensen;Randi Syljuäsen

  • E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC Cdh1

    Jerry Y Hsu;Julie D R Reimann;Claus S Sørensen;Jiri Lukas

  • Histone H4 Lysine 20 methylation: key player in epigenetic regulation of genomic integrity

    Stine Jørgensen;Gunnar Schotta;Claus Storgaard Sørensen

  • Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex

    Claudia Lukas;Claus Storgaard Sørensen;Edgar Kramer;Eric Santoni-Rugiu

  • Hereditary breast and ovarian cancer: new genes in confined pathways

    Finn Cilius Nielsen;Thomas van Overeem Hansen;Claus Storgaard Sørensen

  • Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication

    Claus Storgaard Sørensen;Randi G. Syljuåsen

  • Cyclin-Dependent Kinase Suppression by WEE1 Kinase Protects the Genome through Control of Replication Initiation and Nucleotide Consumption

    Halfdan Beck;Viola Nähse-Kumpf;Marie Sofie Yoo Larsen;Karen A. O'Hanlon

  • Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

    Panagiotis Galanos;Konstantinos Vougas;David Walter;Alexander Polyzos

  • The histone methyltransferase SET8 is required for S-phase progression

    Stine Jørgensen;Ingegerd Elvers;Morten Beck Trelle;Tobias Menzel

  • LEDGF (p75) promotes DNA-end resection and homologous recombination

    Mads Daugaard;Annika Baude;Kasper Fugger;Lou Klitgaard Povlsen

  • The caspase-activated DNase: apoptosis and beyond.

    Brian D. Larsen;Claus S. Sørensen

  • Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase

    Halfdan Beck;Viola Nähse;Marie Sofie Yoo Larsen;Petra Groth

  • A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression.

    Claus Storgaard Sørensen;Claudia Lukas;Edgar R. Kramer;Jan-Michael Peters

  • ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage.

    Claus Storgaard Sørensen;Randi G. Syljuåsen;Jiri Lukas;Jiri Bartek

  • NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint.

    Marina Melixetian;Ditte Kjærsgaard Klein;Claus Storgaard Sørensen;Kristian Helin;Kristian Helin

  • Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis.

    Claus Storgaard Sørensen;Claudia Lukas;Edgar R. Kramer;Jan-Michael Peters

Frequent Co-Authors

Thomas Helleday
Thomas Helleday Karolinska Institute
Jiri Lukas
Jiri Lukas University of Copenhagen
Jiri Bartek
Jiri Bartek Karolinska Institute
Claudia Lukas
Claudia Lukas University of Copenhagen
Vassilis G. Gorgoulis
Vassilis G. Gorgoulis National and Kapodistrian University of Athens
Kristian Helin
Kristian Helin Institute of Cancer Research
Jiri Bartek
Jiri Bartek Karolinska Institute
Juri Rappsilber
Juri Rappsilber Technical University of Berlin
Finn Cilius Nielsen
Finn Cilius Nielsen Copenhagen University Hospital
Ian D. Hickson
Ian D. Hickson University of Copenhagen

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