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D-Index & Metrics

Biology and Biochemistry

D-Index
50
Citations
24022
World Ranking
17392
National Ranking
190

Overview

Claudia Lukas is affiliated with the University of Copenhagen in Denmark, focusing primarily on research within biochemistry, genetics, and molecular biology. Their work spans several subfields, including molecular biology, biophysics, spectroscopy, oncology, and physiology.

The scientist's research concentrates on a variety of topics related to cellular and molecular mechanisms. These include:

  • Cell Image Analysis Techniques
  • Single-cell and spatial transcriptomics
  • Advanced Proteomics Techniques and Applications
  • PARP inhibition in cancer therapy
  • Calcium signaling and nucleotide metabolism
  • Toxin Mechanisms and Immunotoxins
  • DNA Repair Mechanisms

Lukas has co-authored publications with several frequent collaborators, including Andreas Mund, Fabian Coscia, András Kriston, Réka Hollandi, and Ferenc Kovács.

Notable recent papers authored or co-authored by Claudia Lukas include:

  • Deep Visual Proteomics defines single-cell identity and heterogeneity, 2022, Nature Biotechnology
  • The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome, 2021, Nature Communications
  • AI-driven Deep Visual Proteomics defines cell identity and heterogeneity, 2021, bioRxiv (Cold Spring Harbor Laboratory)
  • Author Correction: Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability, 2022, Genome biology

Their work has been published in venues such as Nature Biotechnology, Nature Communications, bioRxiv (Cold Spring Harbor Laboratory), and Genome Biology. These publications reflect an ongoing engagement with advanced proteomic technologies and methodologies to explore cell heterogeneity and regulatory molecular processes.

Best Publications

  • DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

    Jirina Bartkova;Zuzana Horejsí;Karen Koed;Alwin Krämer

  • Human CtIP promotes DNA end resection

    Alessandro A. Sartori;Claudia Lukas;Julia Coates;Martin Mistrik

  • ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

    Ali Jazayeri;Jacob Falck;Claudia Lukas;Jiri Bartek

  • RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins

    Niels Mailand;Simon Bekker-Jensen;Helene Faustrup;Fredrik Melander

  • RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

    Carsten Doil;Niels Mailand;Simon Bekker-Jensen;Patrice Menard

  • Rapid destruction of human Cdc25A in response to DNA damage.

    Niels Mailand;Jacob Falck;Claudia Lukas;Randi G. Syljuåsen

  • Checking on DNA damage in S phase

    Jiri Bartek;Claudia Lukas;Jiri Lukas

  • ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

    Luis Ignacio Toledo;Matthias Altmeyer;Maj-Britt Rask;Claudia Lukas

  • More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

    Jiri Lukas;Claudia Lukas;Jiri Bartek

  • Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway

    Yael Ziv;Dana Bielopolski;Yaron Galanty;Claudia Lukas

  • Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

    Simon Bekker-Jensen;Claudia Lukas;Risa Kitagawa;Fredrik Melander

  • 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress.

    Claudia Lukas;Velibor Savic;Simon Bekker-Jensen;Carsten Doil

  • Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

    Claudia Lukas;Jacob Falck;Jirina Bartkova;Jiri Bartek

  • Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time.

    Jiri Lukas;Claudia Lukas;Jiri Bartek

  • Mdc1 couples DNA double‐strand break recognition by Nbs1 with its H2AX‐dependent chromatin retention

    Claudia Lukas;Fredrik Melander;Manuel Stucki;Jacob Falck

  • Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase.

    Alwin Krämer;Niels Mailand;Claudia Lukas;Randi G. Syljuåsen

  • Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex

    Claudia Lukas;Claus Storgaard Sørensen;Edgar Kramer;Eric Santoni-Rugiu

  • HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

    Simon Bekker-Jensen;Jannie Rendtlew Danielsen;Kasper Fugger;Irina Gromova

  • Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

    Simon Bekker-Jensen;Claudia Lukas;Fredrik Melander;Jiri Bartek

  • TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

    Thorkell Gudjonsson;Matthias Altmeyer;Velibor Savic;Luis Toledo

Frequent Co-Authors

Jiri Lukas
Jiri Lukas University of Copenhagen
Jiri Bartek
Jiri Bartek Karolinska Institute
Jiri Bartek
Jiri Bartek Karolinska Institute
Simon Bekker-Jensen
Simon Bekker-Jensen University of Copenhagen
Niels Mailand
Niels Mailand University of Copenhagen
Claus Storgaard Sørensen
Claus Storgaard Sørensen University of Copenhagen
Jirina Bartkova
Jirina Bartkova Karolinska Institute
Matthias Altmeyer
Matthias Altmeyer University of Zurich
Vassilis G. Gorgoulis
Vassilis G. Gorgoulis National and Kapodistrian University of Athens
Rainer Pepperkok
Rainer Pepperkok European Molecular Biology Laboratory

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