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Molecular Biology

D-Index
85
Citations
33437
World Ranking
843
National Ranking
444

Research.com Recognitions

  • 1998 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1986 - Member of the National Academy of Sciences
  • 1985 - Richard Lounsbery Award, National Academy of Sciences and the French Academy of Sciences for their seminal contributions to our understanding of the structure and function of DNA which were essential and fundamental to the development of recombinant DNA techniques.
  • 1983 - Fellow of the American Academy of Arts and Sciences

Overview

Martin Gellert is affiliated with the National Institute of Diabetes and Digestive and Kidney Diseases in the United States. Their research primarily falls within the domain of Biochemistry, Genetics, and Molecular Biology, with a focus on Molecular Biology as a subfield alongside Immunology, Oncology, Pathology and Forensic Medicine, and Epidemiology.

Their work extensively covers several topics, including DNA Repair Mechanisms, CRISPR and Genetic Engineering, T-cell and B-cell Immunology, DNA and Nucleic Acid Chemistry, Protein Structure and Dynamics, RNA and protein synthesis mechanisms, and PARP inhibition in cancer therapy.

Frequent publication venues for Martin Gellert include:

  • Molecular Cell
  • Nature Structural & Molecular Biology
  • Current Opinion in Structural Biology
  • Nature
  • bioRxiv (Cold Spring Harbor Laboratory)

Recent papers by Martin Gellert reflect their ongoing contribution to structural and molecular biology, with highlights such as:

  • Structure of an activated DNA-PK and its implications for NHEJ (2020, Molecular Cell)
  • Autophosphorylation transforms DNA-PK from protecting to processing DNA ends (2021, Molecular Cell)
  • Two distinct long-range synaptic complexes promote different aspects of end processing prior to repair of DNA breaks by non-homologous end joining (2023, Molecular Cell)
  • Cutting antiparallel DNA strands in a single active site (2020, Nature Structural & Molecular Biology)
  • How mouse RAG recombinase avoids DNA transposition (2020, Nature Structural & Molecular Biology)

Frequent collaborators in their research include Wei Yang, Xuemin Chen, Huaibin Wang, Christopher J. Buehl, and Noah J. Goff.

Martin Gellert's career has been recognized with several awards, including:

  • Fellow of the American Association for the Advancement of Science (AAAS), 1998
  • Member of the National Academy of Sciences, 1986
  • Richard Lounsbery Award from the National Academy of Sciences and the French Academy of Sciences, 1985, for seminal contributions to the understanding of DNA structure and function essential to recombinant DNA techniques
  • Fellow of the American Academy of Arts and Sciences, 1983

Best Publications

  • A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.

    Tanya T Paull;Emmy P Rogakou;Vikky Yamazaki;Cordula U Kirchgessner

  • Helix Formation by Guanylic Acid

    Martin Gellert;Marie N. Lipsett;David R. Davies

  • DNA gyrase: an enzyme that introduces superhelical turns into DNA

    Martin Gellert;Kiyoshi Mizuuchi;Mary H. O'Dea;Howard A. Nash

  • Mobile DNA III

    Nancy Lynn Craig;Michael Chandler;Martin Gellert;Alan M. Lambowitz

  • The 3′ to 5′ Exonuclease Activity of Mre11 Facilitates Repair of DNA Double-Strand Breaks

    Tanya T. Paull;Martin Gellert

  • Nalidixic acid resistance: A second genetic character involved in DNA gyrase activity

    Martin Gellert;Kiyoshi Mizuuchi;Mary H. O'Dea;Tateo Itoh

  • V(D)J Recombination: RAG Proteins, Repair Factors, and Regulation*

    Martin Gellert

  • Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase.

    Martin Gellert;Mary H. O'Dea;Tateo Itoh;Jun-Ichi Tomizawa

  • Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

    J.Fraser McBlane;Dik C. van Gent;Dale A. Ramsden;Charles Romeo

  • DNA Transposition by the RAG1 and RAG2 Proteins: A Possible Source of Oncogenic Translocations

    Kevin Hiom;Meni Melek;Martin Gellert

  • Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

    Tanya T. Paull;Martin Gellert

  • V(D)J recombination: a functional definition of the joining signals.

    Joanne E. Hesse;Michael R. Lieber;Kiyoshi Mizuuchi;Martin Gellert

  • V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes.

    David B. Roth;Joseph P. Menetski;Pamela B. Nakajima;Melvin J. Bosma

  • Regulation of the genes for E. coli DNA gyrase: Homeostatic control of DNA supercoiling

    Rolf Menzel;Martin Gellert

  • The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination

    Michael R. Lieber;Joanne E. Hesse;Susanna Lewis;Gayle C. Bosma

  • Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals.

    Joanne E. Hesse;Joanne E. Hesse;Michael R. Lieber;Michael R. Lieber;Martin Gellert;Martin Gellert;Kiyoshi Mizuuchi;Kiyoshi Mizuuchi

  • Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double‐strand breaks

    Dale A. Ramsden;Martin Gellert

  • Initiation of V(D)J recombination in a cell-free system

    Dik C van Gent;J Fraser McBlane;Dale A Ramsden;Moshe J Sadofsky

  • The RAG1 and RAG2 Proteins Establish the 12/23 Rule in V(D)J Recombination

    Dik C van Gent;Dale A Ramsden;Martin Gellert

  • V(D)J Recombination

    Martin Gellert

Frequent Co-Authors

Kiyoshi Mizuuchi
Kiyoshi Mizuuchi National Institutes of Health
Tanya T. Paull
Tanya T. Paull The University of Texas at Austin
Michael R. Lieber
Michael R. Lieber University of Southern California
Wei Yang
Wei Yang National Institutes of Health
David Roth
David Roth University of Miami
Anthony Maxwell
Anthony Maxwell John Innes Centre
Howard A. Nash
Howard A. Nash MRC Laboratory of Molecular Biology
Dik C. van Gent
Dik C. van Gent Erasmus University Rotterdam
Gary Felsenfeld
Gary Felsenfeld National Institutes of Health
Jun-ichi Tomizawa
Jun-ichi Tomizawa National Institute of Genetics

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