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Yoshitaka Nagai

Yoshitaka Nagai

D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
23143
World Ranking
8479
National Ranking
569

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Amino acid

Yoshitaka Nagai mainly investigates Biochemistry, Molecular biology, Cell biology, Ganglioside and Neurodegeneration. The Peptide, Glycolipid, Phage display and Peptide sequence research Yoshitaka Nagai does as part of his general Biochemistry study is frequently linked to other disciplines of science, such as Tandem repeat, therefore creating a link between diverse domains of science. His studies deal with areas such as Gene expression, Messenger RNA, Alternative splicing, Congenital muscular dystrophy and Dystrophin as well as Molecular biology.

His work in the fields of Cell biology, such as Effector, overlaps with other areas such as Compound eye. His work in Neurodegeneration addresses issues such as Spinocerebellar ataxia, which are connected to fields such as HSF1, Heat shock factor, RNA-binding protein and Ran. His Chaperone-mediated autophagy research integrates issues from BECN1, Autolysosome, MAP1LC3B, Computational biology and Programmed cell death.

His most cited work include:

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (4170 citations)
  • A toxic monomeric conformer of the polyglutamine protein. (266 citations)
  • Glycolipids at the cell surface and their biological functions (264 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in Cell biology, Biochemistry, Molecular biology, Neurodegeneration and Spinocerebellar ataxia. As a member of one scientific family, Yoshitaka Nagai mostly works in the field of Cell biology, focusing on Phenotype and, on occasion, Amyotrophic lateral sclerosis and Parkinson's disease. His study brings together the fields of In vivo and Biochemistry.

The various areas that he examines in his Molecular biology study include Cytoplasm and Gene expression. His Neurodegeneration study incorporates themes from Gene knockdown and Transduction. He has researched Spinocerebellar ataxia in several fields, including RNA and Trinucleotide repeat expansion.

He most often published in these fields:

  • Cell biology (30.96%)
  • Biochemistry (21.83%)
  • Molecular biology (14.72%)

What were the highlights of his more recent work (between 2015-2021)?

  • Cell biology (30.96%)
  • Spinocerebellar ataxia (10.15%)
  • RNA (5.58%)

In recent papers he was focusing on the following fields of study:

His primary areas of investigation include Cell biology, Spinocerebellar ataxia, RNA, Disease and Phenotype. His research in Cell biology intersects with topics in Transgene, Gene knockdown, Neurodegeneration, Parkinson's disease and Drosophila. He combines subjects such as Molecular biology, Substituent and Trinucleotide repeat expansion with his study of RNA.

His Disease study combines topics from a wide range of disciplines, such as Sleep in non-human animals and Neuroscience. His biological study spans a wide range of topics, including Mutation and Amyotrophic lateral sclerosis. Yoshitaka Nagai interconnects BECN1, Programmed cell death, Autolysosome and Physiology in the investigation of issues within Computational biology.

Between 2015 and 2021, his most popular works were:

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (4170 citations)
  • Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31 (60 citations)
  • Molecular Basis of Orb2 Amyloidogenesis and Blockade of Memory Consolidation (49 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Amino acid

Cell biology, Disease, Parkinson's disease, Neurodegeneration and Transgene are his primary areas of study. His work in the fields of Cell biology, such as Protein aggregation, intersects with other areas such as Interpretation. His Neurodegeneration study integrates concerns from other disciplines, such as Genetics and Spinocerebellar ataxia.

His research integrates issues of Mutant, Ataxin and Endosome in his study of Transgene. Biochemistry covers Yoshitaka Nagai research in Organelle. His work carried out in the field of Biochemistry brings together such families of science as Biophysics and Ammonium acetate.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Glycolipids at the cell surface and their biological functions

    Tamio Yamakawa;Yoshitaka Nagai

  • A toxic monomeric conformer of the polyglutamine protein.

    Yoshitaka Nagai;Takashi Inui;Takashi Inui;Takashi Inui;H Akiko Popiel;Nobuhiro Fujikake

  • GQ1b, a bioactive ganglioside that exhibits novel nerve growth factor (NGF)-like activities in the two neuroblastoma cell lines.

    Shuichi Tsuji;Masanobu Arita;Yoshitaka Nagai

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic.

    Toshiaki Takahashi;Shinya Kikuchi;Shinichi Katada;Yoshitaka Nagai

  • Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein

    Peter O Bauer;Anand Goswami;Hon Kit Wong;Misako Okuno

  • Multiple candidate gene analysis identifies α-synuclein as a susceptibility gene for sporadic Parkinson's disease

    Ikuko Mizuta;Wataru Satake;Yuko Nakabayashi;Chiyomi Ito

  • Heat shock transcription factor 1-activating compounds suppress polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones.

    Nobuhiro Fujikake;Yoshitaka Nagai;H. Akiko Popiel;Yuma Okamoto

  • Interaction between Clostridium botulinum neurotoxin and gangliosides.

    Masaru Kitamura;Masao Iwamori;Yoshitaka Nagai

  • Inhibition of Polyglutamine Protein Aggregation and Cell Death by Novel Peptides Identified by Phage Display Screening

    Yoshitaka Nagai;Timothy Tucker;Hongzu Ren;Daniel J. Kenan

  • VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease

    Emiko Miura;Takafumi Hasegawa;Masatoshi Konno;Mari Suzuki

  • Decrease of the D3 dopamine receptor mRNA expression in lymphocytes from patients with Parkinson's disease

    Y. Nagai;S. Ueno;Y. Saeki;F. Soga

  • Intercellular chaperone transmission via exosomes contributes to maintenance of protein homeostasis at the organismal level

    Toshihide Takeuchi;Mari Suzuki;Nobuhiro Fujikake;H. Akiko Popiel

  • Prevention of polyglutamine oligomerization and neurodegeneration by the peptide inhibitor QBP1 in Drosophila

    Yoshitaka Nagai;Nobuhiro Fujikake;Katsuhito Ohno;Hiroyuki Higashiyama

  • Ganglioside syndrome, a new autoimmune neurologic disorder, experimentally induced with brain gangliosides

    Yoshitaka Nagai;Takashi Momoi;Masaki Saito;Eizo Mitsuzawa

  • Bioactive Gangliosides. IV. Ganglioside GQ1b/Ca2+ Dependent Protein Kinase Activity Exists in the Plasma Membrane Fraction of Neuroblastoma Cell Line, GOTO

    Shuichi Tsuji;Junko Nakajima;Tadayuki Sasaki;Yoshitaka Nagai

  • Expression cloning of a CMP-NeuAc:NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1'Cer alpha 2,8-sialyltransferase (GD3 synthase) from human melanoma cells

    Kiyomitsu Nara;Yumiko Watanabe;Kazuo Maruyama;Kohji Kasahara

  • Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31

    Taro Ishiguro;Nozomu Sato;Morio Ueyama;Nobuhiro Fujikake

Frequent Co-Authors

Tatsushi Toda
Tatsushi Toda University of Tokyo
Hideki Mochizuki
Hideki Mochizuki Osaka University
Masamitsu Yamaguchi
Masamitsu Yamaguchi Kyoto Institute of Technology
James R. Burke
James R. Burke Duke University
Warren J. Strittmatter
Warren J. Strittmatter Duke University
Osamu Onodera
Osamu Onodera Niigata University
Keiji Wada
Keiji Wada Japan Agency for Medical Research and Development
Evelina Gatti
Evelina Gatti Aix-Marseille University
Shazib Pervaiz
Shazib Pervaiz National University of Singapore
Hamao Umezawa
Hamao Umezawa National Institutes of Health

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