His primary areas of study are Molecular biology, Blood–brain barrier, Monoclonal antibody, Fusion protein and Transferrin receptor. The study incorporates disciplines such as Gene expression, Small hairpin RNA, Glioma, Genetic enhancement and Gene targeting in addition to Molecular biology. His studies in Gene expression integrate themes in fields like Endocrinology, Internal medicine and Gene isoform.
His studies deal with areas such as Glucose transporter, Pharmacology, In vivo and Cell biology as well as Blood–brain barrier. His Monoclonal antibody research integrates issues from Receptor, Chinese hamster ovary cell and Targeted drug delivery. His research investigates the connection with Fusion protein and areas like Transfection which intersect with concerns in Mucopolysaccharidosis type I, Lysosome, Kinase and Glial cell line-derived neurotrophic factor.
His main research concerns Molecular biology, Blood–brain barrier, Fusion protein, Transferrin receptor and Gene expression. His Molecular biology research is multidisciplinary, relying on both Glucose transporter, Messenger RNA and Biochemistry. The concepts of his Blood–brain barrier study are interwoven with issues in Immunology, Pharmacology, In vivo and Cell biology.
He has included themes like Receptor, Chinese hamster ovary cell, Erythropoietin and Antibody, Monoclonal antibody in his Fusion protein study. Ruben J. Boado interconnects Transcytosis, Genetically modified mouse and Tyrosine hydroxylase in the investigation of issues within Transferrin receptor. Ruben J. Boado has included themes like Genetic enhancement and Transgene in his Gene expression study.
His scientific interests lie mostly in Fusion protein, Blood–brain barrier, Pharmacology, Receptor and Antibody. His Fusion protein research is multidisciplinary, incorporating perspectives in Mucopolysaccharidosis type I, Enzyme replacement therapy, Molecular biology, Transferrin receptor and Monoclonal antibody. Within one scientific family, he focuses on topics pertaining to Targeted drug delivery under Monoclonal antibody, and may sometimes address concerns connected to Cell biology.
Blood–brain barrier is the subject of his research, which falls under Central nervous system. The study incorporates disciplines such as Iduronidase and Mucopolysaccharidosis in addition to Pharmacology. His work in Receptor tackles topics such as Enzyme which are related to areas like Endogeny.
Ruben J. Boado mainly focuses on Fusion protein, Blood–brain barrier, Molecular biology, Monoclonal antibody and Receptor. His research in Fusion protein intersects with topics in Endocrinology, Enzyme replacement therapy, Internal medicine, Transferrin receptor and Antibody. He has researched Endocrinology in several fields, including Iduronidase and Mucopolysaccharidosis type I.
His Blood–brain barrier research integrates issues from Neuroinflammation and Immune system, Immune privilege. His studies in Molecular biology integrate themes in fields like Protein engineering and Protein A. His biological study spans a wide range of topics, including Pharmacokinetics, Pharmacology, Targeted drug delivery and Cell biology.
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Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier. Studies with quantitative western blotting and in situ hybridization.
W M Pardridge;R J Boado;C R Farrell.
Journal of Biological Chemistry (1990)
Selective expression of the large neutral amino acid transporter at the blood-brain barrier.
Ruben J. Boado;Jian Yi Li;Marie Nagaya;Crystal Zhang.
Proceedings of the National Academy of Sciences of the United States of America (1999)
Intravenous RNA Interference Gene Therapy Targeting the Human Epidermal Growth Factor Receptor Prolongs Survival in Intracranial Brain Cancer
Yun Zhang;Yu-feng Zhang;Joshua Bryant;Andrew Charles.
Clinical Cancer Research (2004)
Brain-specific expression of an exogenous gene after i. v. administration
Ningya Shi;Yun Zhang;Chunni Zhu;Ruben J. Boado.
Proceedings of the National Academy of Sciences of the United States of America (2001)
Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor.
M. J. Coloma;Hwa Jeong Lee;A. Kurihara;E. M. Landaw.
Pharmaceutical Research (2000)
Vector-mediated delivery of a polyamide ("peptide") nucleic acid analogue through the blood-brain barrier in vivo.
William M. Pardridge;Ruben J. Boado;Young-Sook Kang.
Proceedings of the National Academy of Sciences of the United States of America (1995)
Immunologic Privilege in the Central Nervous System and the Blood–Brain Barrier
Leslie L Muldoon;Jorge I Alvarez;David J Begley;Ruben J Boado.
Journal of Cerebral Blood Flow and Metabolism (2013)
Intravenous nonviral gene therapy causes normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism.
Yun Zhang;Frederic Calon;Chunni Zhu;Ruben J. Boado.
Human Gene Therapy (2003)
Humanization of anti-human insulin receptor antibody for drug targeting across the human blood-brain barrier.
Ruben J. Boado;Yufeng Zhang;Yun Zhang;William M. Pardridge.
Biotechnology and Bioengineering (2007)
Reengineering biopharmaceuticals for targeted delivery across the blood-brain barrier.
William M Pardridge;Ruben J Boado.
Methods in Enzymology (2012)
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