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Molecular Biology

D-Index
74
Citations
15792
World Ranking
1246
National Ranking
641

Overview

Ruben J. Boado is affiliated with the University of California, Los Angeles in the United States. Their research primarily covers the fields of medicine and materials science, with a focus on several subfields including radiology, nuclear medicine and imaging, biomaterials, physiology, clinical psychology, and oncology.

The scientist's work addresses various topics related to drug delivery and pharmacology. Main areas of investigation include:

  • Nanoparticle-Based Drug Delivery
  • Monoclonal and Polyclonal Antibodies Research
  • Adenosine and Purinergic Signaling
  • Drug Transport and Resistance Mechanisms
  • Pharmacological Effects and Toxicity Studies
  • Barrier Structure and Function Studies
  • Lysosomal Storage Disorders Research

Ruben J. Boado has collaborated frequently with several researchers including Toshiaki Ikeda, Hiroyuki Sonoda, Charlotte Pfrimmer, William M. Pardridge, and Ulrich Bickel.

Their recent publications exemplify the scope of their research interests. Selected papers include:

  • "IgG Fusion Proteins for Brain Delivery of Biologics via Blood-Brain Barrier Receptor-Mediated Transport," published in Pharmaceutics, 2022
  • "Treatment of CLN1 disease with a blood-brain barrier penetrating lysosomal enzyme," published in Molecular Genetics and Metabolism Reports, 2022
  • "The legacy of William M. Pardridge (1947-2024) on the science and fields concerned with the physiology of the blood-brain barrier and the transport of drugs to the brain," published in Fluids and Barriers of the CNS, 2025
  • "Treatment of CLN1 disease with a blood-brain barrier penetrating lysosomal enzyme AGT-194," published in Molecular Genetics and Metabolism, 2023
  • "Impact of the Drug Act on Foreign Mothers Incarcerated in Arica," published in Feminist Criminology, 2025

The venues where Ruben J. Boado has published frequently consist of Pharmaceutics, Fluids and Barriers of the CNS, Molecular Genetics and Metabolism Reports, Molecular Genetics and Metabolism, and Feminist Criminology. These reflect a multidisciplinary approach spanning pharmacology, physiology, genetics, and social sciences.

Best Publications

  • Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier. Studies with quantitative western blotting and in situ hybridization.

    W M Pardridge;R J Boado;C R Farrell

  • Selective expression of the large neutral amino acid transporter at the blood-brain barrier.

    Ruben J. Boado;Jian Yi Li;Marie Nagaya;Crystal Zhang

  • Intravenous RNA Interference Gene Therapy Targeting the Human Epidermal Growth Factor Receptor Prolongs Survival in Intracranial Brain Cancer

    Yun Zhang;Yu-feng Zhang;Joshua Bryant;Andrew Charles

  • Brain-specific expression of an exogenous gene after i. v. administration

    Ningya Shi;Yun Zhang;Chunni Zhu;Ruben J. Boado

  • Immunologic Privilege in the Central Nervous System and the Blood–Brain Barrier

    Leslie L Muldoon;Jorge I Alvarez;David J Begley;Ruben J Boado

  • Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor.

    M. J. Coloma;Hwa Jeong Lee;A. Kurihara;E. M. Landaw

  • Vector-mediated delivery of a polyamide ("peptide") nucleic acid analogue through the blood-brain barrier in vivo.

    William M. Pardridge;Ruben J. Boado;Young-Sook Kang

  • Humanization of anti-human insulin receptor antibody for drug targeting across the human blood-brain barrier.

    Ruben J. Boado;Yufeng Zhang;Yun Zhang;William M. Pardridge

  • Intravenous nonviral gene therapy causes normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism.

    Yun Zhang;Frederic Calon;Chunni Zhu;Ruben J. Boado

  • Reengineering biopharmaceuticals for targeted delivery across the blood-brain barrier.

    William M Pardridge;Ruben J Boado

  • Fusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and abeta fibril disaggregation.

    Ruben J. Boado;Yufeng Zhang;Yun Zhang;Chun-Fang Xia

  • Receptor-mediated gene targeting to tissues in vivo following intravenous administration of pegylated immunoliposomes

    Ningya Shi;Ruben J. Boado;William M. Pardridge

  • GENE EXPRESSION OF GLUT3 AND GLUT1 GLUCOSE TRANSPORTERS IN HUMAN BRAIN TUMORS

    Ruben J. Boado;Keith L. Black;William M. Pardridge

  • Upregulation of blood-brain barrier GLUT1 glucose transporter protein and mRNA in experimental chronic hypoglycemia.

    Arno K. Kumagai;Young Sook Kang;Rubén J. Boado;William M. Pardridge

  • Genetic engineering of a lysosomal enzyme fusion protein for targeted delivery across the human blood-brain barrier

    Ruben J. Boado;Yun Zhang;Yufeng Zhang;Chun-fang Xia

  • Engineering and expression of a chimeric transferrin receptor monoclonal antibody for blood-brain barrier delivery in the mouse.

    Ruben J. Boado;Yun Zhang;Yuntao Wang;William M. Pardridge

  • In vivo knockdown of gene expression in brain cancer with intravenous RNAi in adult rats

    Yun Zhang;Ruben J. Boado;William M. Pardridge

  • Drug Delivery of Antisense Molecules to the Brain for Treatment of Alzheimer’s Disease and Cerebral AIDS

    Ruben J. Boado;Haruhisa Tsukamoto;William M. Pardridge

  • Receptor‐mediated delivery of an antisense gene to human brain cancer cells

    Yun Zhang;Hwa Jeong Lee;Ruben J. Boado;William M. Pardridge

  • Blood—Brain Barrier Genomics

    Jian Yi Li;Ruben J. Boado;William M. Pardridge

Frequent Co-Authors

William M. Pardridge
William M. Pardridge University of California, Los Angeles
Inder J. Chopra
Inder J. Chopra University of California, Los Angeles
Roberto Giugliani
Roberto Giugliani Federal University of Rio Grande do Sul
David H. Cribbs
David H. Cribbs University of California, Irvine
Eric V. Shusta
Eric V. Shusta University of Wisconsin–Madison
David H. Solomon
David H. Solomon University of California, Los Angeles
William W. Chin
William W. Chin Harvard Medical School
Keith L. Black
Keith L. Black Cedars-Sinai Medical Center
David A. Campbell
David A. Campbell University of California, Los Angeles
Frédéric Calon
Frédéric Calon Université Laval

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