World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
50
Citations
16354
World Ranking
17422
National Ranking
425

Overview

Isaac J. Nijman is affiliated with Utrecht University in the Netherlands and has contributed to research primarily in the fields of biochemistry, genetics, and molecular biology, with additional work in medicine. Their expertise spans several subfields including genetics, molecular biology, oncology, immunology, and neurology.

Their research covers a range of topics with multiple publications focusing on areas such as:

  • Cancer cells and metastasis
  • Genetic and phenotypic traits in livestock
  • Genetic mapping and diversity in plants and animals
  • Single-cell and spatial transcriptomics
  • Genomics and rare diseases
  • Cancer immunotherapy and biomarkers
  • Wnt/β-catenin signaling in development and cancer

Among their recent scientific papers are:

  • "Modifier genes in SCN1A-related epilepsy syndromes," 2020, published in Molecular Genetics & Genomic Medicine
  • "Geographical contrasts of Y-chromosomal haplogroups from wild and domestic goats reveal ancient migrations and recent introgressions," 2022, published in Molecular Ecology
  • "Investigation of Genetic Modifiers of Copper Toxicosis in Labrador Retrievers," 2020, published in Life
  • "Multiplex spatial omics reveals changes in immune-epithelial crosstalk during inflammation and dysplasia development in chronic IBD patients," 2024, published in iScience
  • "Pseudobudding: ruptured glands do not represent true tumor buds," 2023, published in The Journal of Pathology

Isaac J. Nijman has frequently published in venues such as bioRxiv (Cold Spring Harbor Laboratory), The Journal of Pathology, Molecular Ecology, iScience, and Molecular Genetics & Genomic Medicine. The scientist's collaborations often include researchers like Benjamin D. Rosen, Philippe Bardou, Thomas Faraut, Tristan Cumer, and Kevin G. Daly, each with whom Nijman has coauthored multiple papers.

Best Publications

  • Organoid Models of Human and Mouse Ductal Pancreatic Cancer

    Sylvia F. Boj;Chang Il Hwang;Chang Il Hwang;Lindsey A. Baker;Lindsey A. Baker;Iok In Christine Chio;Iok In Christine Chio

  • Sambamba: fast processing of NGS alignment formats

    Artem Tarasov;Albert J. Vilella;Edwin Cuppen;Isaac J. Nijman

  • A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

    Norman Sachs;Joep de Ligt;Oded Kopper;Ewa Gogola

  • Tissue-specific mutation accumulation in human adult stem cells during life

    Francis Blokzijl;Joep de Ligt;Myrthe Jager;Valentina Sasselli

  • A systematic genome-wide analysis of zebrafish protein-coding gene function

    Ross N. W. Kettleborough;Elisabeth M. Busch-Nentwich;Steven A. Harvey;Christopher M. Dooley

  • Whole-genome sequence variation, population structure and demographic history of the Dutch population

    Laurent C. Francioli;Androniki Menelaou;Sara L. Pulit;Freerk van Dijk

  • A medium density genetic linkage map of the bovine genome

    W. Barendse;D. Vaiman;S. J. Kemp;Y. Sugimoto

  • Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells.

    Pantelis Hatzis;Laurens G van der Flier;Marc A van Driel;Victor Guryev

  • Llama heavy-chain V regions consist of at least four distinct subfamilies revealing novel sequence features.

    Michiel M. Harmsen;Robin C. Ruuls;Isaäc J. Nijman;Theodoor A. Niewold

  • Pyrosequencing-based comparative genome analysis of the nosocomial pathogen Enterococcus faecium and identification of a large transferable pathogenicity island

    Willem van Schaik;Janetta Top;David R Riley;Jos Boekhorst

  • Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer

    Wigard P Kloosterman;Marlous Hoogstraat;Oscar Paling;Masoumeh Tavakoli-Yaraki

  • Dominant missense mutations in ABCC9 cause Cantú syndrome

    Magdalena Harakalova;Jeske J T van Harssel;Paulien A Terhal;Stef van Lieshout

  • Maternal and paternal lineages in cross-breeding bovine species. Has wisent a hybrid origin?

    Edward L. C. Verkaar;Isaäc J. Nijman;Maurice Beeke;Eline Hanekamp

  • Hybridization of banteng (Bos javanicus) and zebu (Bos indicus) revealed by mitochondrial DNA, satellite DNA, AFLP and microsatellites

    I.J. Nijman;M. Otsen;E.L.C. Verkaar;C. de Ruijter

  • Targeted next-generation sequencing: a novel diagnostic tool for primary immunodeficiencies.

    Isaac J Nijman;Joris M van Montfrans;Marlous Hoogstraat;Marianne L Boes

  • Effectiveness of whole-exome sequencing and costs of the traditional diagnostic trajectory in children with intellectual disability

    Glen R Monroe;Gerardus W Frederix;Sanne M C Savelberg;Tamar I de Vries

  • Loss of Syntaxin 3 Causes Variant Microvillus Inclusion Disease

    Caroline L. Wiegerinck;Andreas R. Janecke;Kerstin Schneeberger;Georg F. Vogel

  • Primary Colorectal Cancers and Their Subsequent Hepatic Metastases Are Genetically Different: Implications for Selection of Patients for Targeted Treatment

    Joost S. Vermaat;Isaac J. Nijman;Marco J. Koudijs;Frank L. Gerritse

  • Differentiation of cattle species in beef by PCR-RFLP of mitochondrial and satellite DNA.

    E.L.C. Verkaar;I.J. Nijman;K. Boutaga;J.A. Lenstra

  • Molecular characterisation of the Theileria buffeli/orientalis group

    M. J. Gubbels;Yin Hong;M. van der Weide;Bai Qi

Frequent Co-Authors

Edwin Cuppen
Edwin Cuppen Utrecht University
Johannes A. Lenstra
Johannes A. Lenstra Utrecht University
Victor Guryev
Victor Guryev University Medical Center Groningen
Nine V.A.M. Knoers
Nine V.A.M. Knoers University Medical Center Groningen
Emile E. Voest
Emile E. Voest Antoni van Leeuwenhoek Hospital
Michal Mokry
Michal Mokry Utrecht University
Wigard P. Kloosterman
Wigard P. Kloosterman Utrecht University
Paolo Ajmone-Marsan
Paolo Ajmone-Marsan Catholic University of the Sacred Heart
John L. Williams
John L. Williams University of Adelaide
Bobby P.C. Koeleman
Bobby P.C. Koeleman Utrecht University

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