Philippe A. Halban

Research.com Recognitions

• 2023 - Research.com Biology and Biochemistry in Switzerland Leader Award

Overview

Best Publications

• Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.

  M. Asfari;D. Janjic;Paolo Meda;Guodong Li

  1715
  Citations

• Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

  Kathrin Maedler;Pavel Sergeev;Frédéric Ris;José Oberholzer

  1592
  Citations

• β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment

  Philippe A. Halban;Kenneth S. Polonsky;Donald W. Bowden;Meredith A. Hawkins

  1164
  Citations

• Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

  Helga Ellingsgaard;Irina Hauselmann;Beat Schuler;Abdella M Habib

  976
  Citations

• Glucagon-like Peptide-1 Receptor Signaling Modulates β Cell Apoptosis

  Yazhou Li;Tanya Hansotia;Bernardo Yusta;Frederic Ris

  845
  Citations

• Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications

  M. Y. Donath;Philippe A. Halban

  556
  Citations

• Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.

  Marianne Böni-Schnetzler;Jeffrey Thorne;Géraldine Parnaud;Lorella Marselli

  435
  Citations

• Sorting and processing of secretory proteins.

  Philippe A. Halban;Jean-Claude Irminger

  416
  Citations

• Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets.

  Kathrin Maedler;Pavel Sergeev;Jan A. Ehses;Zoltan Mathe

  340
  Citations

• Interleukin-6 regulates pancreatic alpha-cell mass expansion.

  Helga Ellingsgaard;Jan A Ehses;Eva B Hammar;Leentje Van Lommel

  324
  Citations

• Regulation of immunoreactive-insulin release from a rat cell line (RINm5F)

  G. A. Praz;Philippe A. Halban;Claes Wollheim;B. Blondel

  319
  Citations

• Release of Incompletely Processed Proinsulin Is the Cause of the Disproportionate Proinsulinemia of NIDDM

  Steven E Kahn;Philippe A Halban

  302
  Citations

• SNAP-25 is expressed in islets of Langerhans and is involved in insulin release.

  Karin Sadoul;Jochen Lang;C. Montecucco;U. Weller

  297
  Citations

• Dominant Negative Pathogenesis by Mutant Proinsulin in the Akita Diabetic Mouse

  Tetsuro Izumi;Hiromi Yokota-Hashimoto;Shengli Zhao;Jie Wang

  293
  Citations

• Importance of cell-matrix interactions in rat islet beta-cell secretion in vitro: role of alpha6beta1 integrin.

  Domenico Bosco;Paolo Meda;Philippe A. Halban;Dominique G. Rouiller

  285
  Citations

• Cytokine production by islets in health and diabetes: cellular origin, regulation and function

  Marc Y. Donath;Marianne Böni-Schnetzler;Helga Ellingsgaard;Philippe A. Halban

  278
  Citations

• Proliferation of sorted human and rat beta cells

  Géraldine Parnaud;Domenico Bosco;Thierry Berney;Francois Pattou

  276
  Citations

• Islet Inflammation and Fibrosis in a Spontaneous Model of Type 2 Diabetes, the GK Rat

  Françoise Homo-Delarche;Sophie Calderari;Jean-Claude Irminger;Marie-Noëlle Gangnerau

  270
  Citations

• Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway.

  C. J. Rhodes;Philippe A. Halban

  267
  Citations

• The Possible Importance of Contact between Pancreatic Islet Cells for the Control of Insulin Release

  Philippe A. Halban;Claes B. Wollheim;Benigna Blondel;Paolo Meda

  255
  Citations