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Molecular Biology

D-Index
87
Citations
28218
World Ranking
798
National Ranking
422

Overview

Bruce Demple is affiliated with Stony Brook University in the United States. Their research primarily focuses on the molecular mechanisms underlying DNA repair and related cellular processes. They have contributed to fields including biochemistry, genetics, molecular biology, and medicine, with particular emphasis on molecular biology as a subfield.

The scientist's work spans various topics such as DNA repair mechanisms, cell death mechanisms and regulation, DNA and nucleic acid chemistry, PARP inhibition in cancer therapy, advanced biosensing and bioanalysis techniques, acute lymphoblastic leukemia research, and the biological effects of spaceflight.

Recent publications by Bruce Demple include:

  • Oxidative DNA-protein crosslinks formed in mammalian cells by abasic site lyases involved in DNA repair, 2020, DNA Repair
  • Knockout and Inhibition of Ape1: Roles of Ape1 in Base Excision DNA Repair and Modulation of Gene Expression, 2022, Antioxidants
  • Artificial Space Weathering to Mimic Solar Wind Enhances the Toxicity of Lunar Dust Simulants in Human Lung Cells, 2024, GeoHealth
  • Intraluminal vesicle trafficking is involved in the secretion of base excision repair protein APE1, 2024, FEBS Journal
  • Maintenance of Flap Endonucleases for Long-Patch Base Excision DNA Repair in Mouse Muscle and Neuronal Cells Differentiated In Vitro, 2023, International Journal of Molecular Sciences

Their frequent coauthors include Zhouyiyuan Xue, Jason Luis Quiñones, Upasna Thapar, Jack Bauer, and Patrick James Sutton. This reflects collaboration within a research network addressing DNA repair and related biochemical pathways.

Bruce Demple's publications have appeared repeatedly in journals such as DNA Repair and Nucleic Acids Research, while also contributing to Antioxidants, GeoHealth, and FEBS Journal. These venues reflect a focus on biochemical and molecular studies with applications in health, toxicity, and environmental interactions.

Best Publications

  • Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

    Raul Mostoslavsky;Katrin F. Chua;Katrin F. Chua;David B. Lombard;Wendy W. Pang

  • Repair of Oxidative Damage to DNA: Enzymology and Biology

    Bruce Demple;Lynn Harrison

  • Positive control of a global antioxidant defense regulon activated by superoxide-generating agents in Escherichia coli.

    J T Greenberg;P Monach;J H Chou;P D Josephy

  • Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes.

    Bruce Demple;Tory Herman;Davis S. Chen

  • Genome-wide transcriptional profiling of the Escherichia coli responses to superoxide stress and sodium salicylate.

    Pablo J. Pomposiello;Marjon H. J. Bennik;Bruce Demple

  • Inducible repair of oxidative DNA damage in Escherichia coli

    Bruce Demple;James Halbrook;James Halbrook

  • Regulation of bacterial oxidative stress genes.

    Bruce Demple

  • Redox-operated genetic switches : the SoxR and OxyR transcription factors

    Pablo J Pomposiello;Bruce Demple

  • Interaction of human apurinic endonuclease and DNA polymerase β in the base excision repair pathway

    Richard A. O. Bennett;David M. Wilson;Donny Wong;Bruce Demple

  • Role of the acrAB locus in organic solvent tolerance mediated by expression of marA, soxS, or robA in Escherichia coli.

    David G. White;John D. Goldman;Bruce Demple;Stuart B. Levy

  • An iron-sulfur center essential for transcriptional activation by the redox-sensing SoxR protein.

    E Hidalgo;B Demple

  • Activation by nitric oxide of an oxidative-stress response that defends Escherichia coli against activated macrophages

    Tatsuo Nunoshiba;Teresa Derojas-Walker;John S. Wishnok;Steven R. Tannenbaum

  • Molecular characterization of the soxRS genes of Escherichia coli: two genes control a superoxide stress regulon.

    Carlos F. Amábile-Cuevas;Bruce Demple

  • DNA N-glycosylases and UV repair.

    Bruce Demple;Stuart Linn

  • Metabolic Sources of Hydrogen Peroxide in Aerobically Growing Escherichia coli

    Beatriz González-Flecha;Bruce Demple

  • Direct nitric oxide signal transduction via nitrosylation of iron-sulfur centers in the SoxR transcription activator

    Huangen Ding;Bruce Demple

  • Two distinct human DNA diesterases that hydrolyze 3′-blocking deoxyribose fragments from oxidized DNA

    Davis S. Chen;Tory Herman;Bruce Demple

  • Two-stage control of an oxidative stress regulon: the Escherichia coli SoxR protein triggers redox-inducible expression of the soxS regulatory gene.

    T Nunoshiba;E Hidalgo;C F Amábile Cuevas;B Demple

  • A Vital Role for Ape1/Ref1 Protein in Repairing Spontaneous DNA Damage in Human Cells

    Hua Fung;Bruce Demple

  • Exonuclease III and endonuclease IV remove 3' blocks from DNA synthesis primers in H2O2-damaged Escherichia coli.

    Bruce Demple;Arlen Johnson;David Fung

Frequent Co-Authors

Jean T. Greenberg
Jean T. Greenberg University of Chicago
Arlen W. Johnson
Arlen W. Johnson The University of Texas at Austin
David M. Wilson
David M. Wilson AstraZeneca (United Kingdom)
Gianluca Tell
Gianluca Tell University of Udine
Stuart Linn
Stuart Linn University of California, Berkeley
Brendan D. Price
Brendan D. Price Harvard University
Stuart B. Levy
Stuart B. Levy Tufts University
Vilhelm A. Bohr
Vilhelm A. Bohr University of Copenhagen
David G. White
David G. White United States Food and Drug Administration
Jacqueline K. Barton
Jacqueline K. Barton California Institute of Technology

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