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Microbiology

D-Index
78
Citations
33938
World Ranking
1248
National Ranking
553

Overview

James A. Imlay is affiliated with the University of Illinois at Urbana-Champaign in the United States. Their research focuses predominantly on the field of Biochemistry, Genetics and Molecular Biology, with specific interests spanning Molecular Biology, Nutrition and Dietetics, Biomedical Engineering, Genetics, and Oncology.

The scientist's recent papers highlight key investigations into microbial responses to oxidative stress and oxygen tolerance. Notable publications include:

  • When anaerobes encounter oxygen: mechanisms of oxygen toxicity, tolerance and defence, 2021, Nature Reviews Microbiology
  • How Microbes Defend Themselves From Incoming Hydrogen Peroxide, 2021, Frontiers in Immunology
  • How Microbes Evolved to Tolerate Oxygen, 2020, Trends in Microbiology
  • Identifying the mediators of intracellular E. coli inactivation under UVA light: The (photo) Fenton process and singlet oxygen, 2022, Water Research
  • Shear rate sensitizes bacterial pathogens to H 2 O 2 stress, 2023, Proceedings of the National Academy of Sciences

Frequent co-authors in their research include Anshika Gupta, Yidan Zhou, Ananya Sen Gupta, Maryam Khademian, and Gilberto C. Padron.

James A. Imlay publishes regularly in several scientific venues. The most common include:

  • Molecular Microbiology
  • Proceedings of the National Academy of Sciences
  • mBio
  • Nature Reviews Microbiology
  • Frontiers in Immunology

The main topics covered throughout their work focus on various aspects of microbial physiology and oxidative biology. These include:

  • Trace Elements in Health
  • Bacterial Genetics and Biotechnology
  • Redox biology and oxidative stress
  • Microbial Community Ecology and Physiology
  • Microbial Fuel Cells and Bioremediation
  • Mitochondrial Function and Pathology
  • Microfluidic and Bio-sensing Technologies

Best Publications

  • Pathways of Oxidative Damage

    James A. Imlay

  • DNA damage and oxygen radical toxicity

    James A. Imlay;Stuart Linn

  • Cellular Defenses against Superoxide and Hydrogen Peroxide

    James A. Imlay

  • Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro.

    James A. Imlay;Sherman M. Chin;Stuart Linn

  • The molecular mechanisms and physiological consequences of oxidative stress: lessons from a model bacterium.

    James A. Imlay

  • The iron-sulfur clusters of dehydratases are primary intracellular targets of copper toxicity.

    Lee Macomber;James A. Imlay

  • Superoxide accelerates DNA damage by elevating free-iron levels

    Kay Keyer;James A. Imlay

  • Alkyl hydroperoxide reductase is the primary scavenger of endogenous hydrogen peroxide in Escherichia coli.

    Lauren Costa Seaver;James A. Imlay

  • Iron-sulphur clusters and the problem with oxygen.

    James A. Imlay

  • Cell Death from Antibiotics Without the Involvement of Reactive Oxygen Species

    Yuanyuan Liu;James A. Imlay

  • High Levels of Intracellular Cysteine Promote Oxidative DNA Damage by Driving the Fenton Reaction

    Sunny Park;James A. Imlay

  • Hydrogen Peroxide Fluxes and Compartmentalization inside Growing Escherichia coli

    Lauren Costa Seaver;James A. Imlay

  • Assay of metabolic superoxide production in Escherichia coli

    James A Imlay;I. Fridovich

  • Mutagenesis and stress responses induced in Escherichia coli by hydrogen peroxide

    J A Imlay;S Linn

  • Why do bacteria use so many enzymes to scavenge hydrogen peroxide

    Surabhi Mishra;James Imlay

  • Bimodal pattern of killing of DNA-repair-defective or anoxically grown Escherichia coli by hydrogen peroxide.

    J A Imlay;S Linn

  • Substantial DNA damage from submicromolar intracellular hydrogen peroxide detected in Hpx- mutants of Escherichia coli

    Sunny Park;Xiaojun You;James A. Imlay

  • Micromolar intracellular hydrogen peroxide disrupts metabolism by damaging iron-sulfur enzymes

    Soojin Jang;James A. Imlay

  • Intracellular Copper Does Not Catalyze the Formation of Oxidative DNA Damage in Escherichia coli

    Lee Macomber;Christopher Rensing;James A. Imlay

  • Manganese import is a key element of the OxyR response to hydrogen peroxide in Escherichia coli

    Adil Anjem;Shery Varghese;James A. Imlay

  • The cysteine desulfurase, IscS, has a major role in in vivo Fe-S cluster formation in Escherichia coli.

    Christopher J. Schwartz;Ouliana Djaman;James A. Imlay;Patricia J. Kiley

  • The identification of primary sites of superoxide and hydrogen peroxide formation in the aerobic respiratory chain and sulfite reductase complex of Escherichia coli.

    Kevin R. Messner;James A. Imlay

Frequent Co-Authors

Irwin Fridovich
Irwin Fridovich Duke University
Stuart Linn
Stuart Linn University of California, Berkeley
Jeffrey N. Weiser
Jeffrey N. Weiser New York University
Daniel J. Hassett
Daniel J. Hassett University of Cincinnati Medical Center
Dennis J. Thiele
Dennis J. Thiele Sisu Pharma
Anthony B. Schryvers
Anthony B. Schryvers University of Calgary
Jian Ku Shang
Jian Ku Shang Chinese Academy of Sciences
Wilfred A. van der Donk
Wilfred A. van der Donk University of Illinois at Urbana-Champaign
James M. Slauch
James M. Slauch University of Illinois at Urbana-Champaign
Joan Selverstone Valentine
Joan Selverstone Valentine University of California, Los Angeles

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