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Biology and Biochemistry

D-Index
63
Citations
18710
World Ranking
10038
National Ranking
726

Overview

Sigurd Lenzen is affiliated with Hannover Medical School in Germany and focuses primarily on research within medicine and biochemistry, genetics, and molecular biology. Their work spans several subfields including surgery, genetics, endocrinology, diabetes and metabolism, molecular biology, and physiology.

The main research topics explored by Lenzen include pancreatic function and diabetes, diabetes and associated disorders, diabetes management and research, diet, metabolism, and disease, ferroptosis and cancer prognosis, heme oxygenase-1 and carbon monoxide, and advanced glycation end products research.

Lenzen's recent published papers include:

  • The central role of glutathione peroxidase 4 in the regulation of ferroptosis and its implications for pro-inflammatory cytokine-mediated beta-cell death (2021, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease)
  • The pro-radical hydrogen peroxide as a stable hydroxyl radical distributor: lessons from pancreatic beta cells (2022, Archives of Toxicology)
  • Pancreas Pathology of Latent Autoimmune Diabetes in Adults (LADA) in Patients and in a LADA Rat Model Compared With Type 1 Diabetes (2020, Diabetes)
  • Differential effects of saturated and unsaturated free fatty acids on ferroptosis in rat β-cells (2022, The Journal of Nutritional Biochemistry)
  • Remission of autoimmune diabetes by anti-TCR combination therapies with anti-IL-17A or/and anti-IL-6 in the IDDM rat model of type 1 diabetes (2020, BMC Medicine)

Frequent co-authors working with Lenzen include Anne Jörns, Thomas Plötz, Dirk Wedekind, Anna-Sophie von Hanstein, and Ilir Mehmeti.

Key publication venues featured in Lenzen's research are the Journal of Molecular Medicine, Diabetes, Diabetologie und Stoffwechsel, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, and Archives of Toxicology.

Best Publications

  • The mechanisms of alloxan- and streptozotocin-induced diabetes.

    S. Lenzen

  • Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities.

    Miriam Cnop;Nils Welsh;Jean-Christophe Jonas;Anne Jörns

  • Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells.

    Markus Tiedge;Stephan Lortz;Jens Drinkgern;Sigurd Lenzen

  • Oxidative stress: the vulnerable β-cell

    Sigurd Lenzen

  • Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin.

    M. Elsner;B. Guldbakke;M. Tiedge;R. Munday

  • Alloxan: history and mechanism of action.

    S Lenzen;U Panten

  • Concentration-dependent effects of tolbutamide, meglitinide, glipizide, glibenclamide and diazoxide on ATP-regulated K+ currents in pancreatic B-cells.

    B. J. Zünkler;S. Lenzen;K. Manner;U. Panten

  • Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes.

    Stephan Lortz;Markus Tiedge;Thomas Nachtwey;Allan E. Karlsen

  • Complementary action of antioxidant enzymes in the protection of bioengineered insulin-producing RINm5F cells against the toxicity of reactive oxygen species.

    Markus Tiedge;Stephan Lortz;Rex Munday;Sigurd Lenzen

  • Peroxisome-Generated Hydrogen Peroxide as Important Mediator of Lipotoxicity in Insulin-Producing Cells

    Matthias Elsner;Wiebke Gehrmann;Sigurd Lenzen

  • Control of insulin secretion by sulfonylureas, meglitinide and diazoxide in relation to their binding to the sulfonylurea receptor in pancreatic islets.

    Uwe Panten;Johanna Burgfeld;Frank Goerke;Michael Rennicke

  • Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-kappaB activation in insulin-producing cells.

    Anna Karenina Azevedo-Martins;Stephan Lortz;Sigurd Lenzen;Rui Curi

  • Thyroid Hormones, Gonadal and Adrenocortical Steroids and the Function of the Islets of Langerhans

    Sigurd Lenzen;Clifford J. Bailey

  • Role of metabolically generated reactive oxygen species for lipotoxicity in pancreatic β‐cells

    W. Gehrmann;M. Elsner;S. Lenzen

  • Thiol-group reactivity, hydrophilicity and stability of alloxan, its reduction products and its N-methyl derivatives and a comparison with ninhydrin

    Sigurd Lenzen;Rex Munday

  • Importance of the GLUT2 glucose transporter for pancreatic beta cell toxicity of alloxan

    M. Elsner;M. Tiedge;B. Guldbakke;R. Munday

  • A Fresh View of Glycolysis and Glucokinase Regulation: History and Current Status

    Sigurd Lenzen

  • Mitochondrial Catalase Overexpression Protects Insulin-Producing Cells Against Toxicity of Reactive Oxygen Species and Proinflammatory Cytokines

    Ewa Gurgul;Stephan Lortz;Markus Tiedge;Anne Jörns

  • Comparative toxicity of alloxan, N-alkylalloxans and ninhydrin to isolated pancreatic islets in vitro

    A Jorns;R Munday;M Tiedge;S Lenzen

  • Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes

    Michele Solimena;Michele Solimena;Anke M. Schulte;Lorella Marselli;Florian Ehehalt

Frequent Co-Authors

Peter R. Flatt
Peter R. Flatt University of Ulster
Decio L. Eizirik
Decio L. Eizirik Université Libre de Bruxelles
Piero Marchetti
Piero Marchetti University of Pisa
Clifford J. Bailey
Clifford J. Bailey Aston University
Itamar Raz
Itamar Raz Hebrew University of Jerusalem
Claes B. Wollheim
Claes B. Wollheim University of Geneva
Steven J. Sandler
Steven J. Sandler University of Massachusetts Amherst
John A. Todd
John A. Todd University of Oxford

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