Philip Newsholme focuses on Biochemistry, Glutamine, Metabolism, Internal medicine and Endocrinology. His biological study deals with issues like Beta cell, which deal with fields such as NADPH oxidase and Oligomycin. His Glutamine research is multidisciplinary, relying on both Cytokine, Cell growth, Ketone bodies, Immune system and Cell biology.
His studies deal with areas such as Homeostasis and Function as well as Metabolism. Internal medicine is closely attributed to Type 2 diabetes in his study. His study deals with a combination of Endocrinology and Context.
His scientific interests lie mostly in Internal medicine, Endocrinology, Biochemistry, Insulin and Metabolism. As part of his studies on Internal medicine, Philip Newsholme often connects relevant areas like Type 2 diabetes. As a part of the same scientific study, he usually deals with the Endocrinology, concentrating on Inflammation and frequently concerns with Immune system.
His study explores the link between Biochemistry and topics such as Molecular biology that cross with problems in DNA fragmentation and Oleic acid. His Insulin study combines topics in areas such as Secretion and Intracellular. The various areas that Philip Newsholme examines in his Metabolism study include Macrophage and Alanine.
Philip Newsholme mainly investigates Internal medicine, Endocrinology, Cell biology, Insulin and Insulin resistance. His studies in Internal medicine integrate themes in fields like Glutamine and Intracellular. In his research, Immune system is intimately related to Inflammation, which falls under the overarching field of Endocrinology.
Many of his research projects under Cell biology are closely connected to Population with Population, tying the diverse disciplines of science together. His Insulin research is multidisciplinary, incorporating elements of Diabetes mellitus and Secretion. His Metabolism research is under the purview of Biochemistry.
His primary areas of investigation include Internal medicine, Endocrinology, Insulin resistance, Inflammation and Biochemistry. Philip Newsholme works in the field of Internal medicine, focusing on NADPH oxidase in particular. His Endocrinology study combines topics from a wide range of disciplines, such as Cell biology, Sirtuin 1 and Mitochondrial biogenesis.
The various areas that he examines in his Insulin resistance study include Immunology, Metabolic syndrome, Type 2 diabetes and Intracellular. His Biochemistry study frequently links to adjacent areas such as Skeletal muscle. Philip Newsholme focuses mostly in the field of Insulin, narrowing it down to matters related to Oxidative stress and, in some cases, Reactive oxygen species.
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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
Seth L Masters;Aisling Dunne;Shoba L Subramanian;Rebecca L Hull.
Nature Immunology (2010)
Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity.
P. Newsholme;E. P. Haber;S. M. Hirabara;E. L. O. Rebelato.
The Journal of Physiology (2007)
Glutamine and glutamate—their central role in cell metabolism and function
Philip Newsholme;Joaquim Procopio;Manuela Maria Ramos Lima;Tania Cristina Pithon-Curi.
Cell Biochemistry and Function (2003)
Why Is l-Glutamine Metabolism Important to Cells of the Immune System in Health, Postinjury, Surgery or Infection?
Journal of Nutrition (2001)
Molecular mechanisms of glutamine action.
R. Curi;C.J. Lagranha;S.Q. Doi;D.F. Sellitti.
Journal of Cellular Physiology (2005)
Glutamine and glutamate as vital metabolites
P. Newsholme;M.M.R. Lima;J. Procopio;T.C. Pithon-Curi.
Brazilian Journal of Medical and Biological Research (2003)
Glutamine: Metabolism and immune function, supplementation and clinical translation
Vinicius Cruzat;Marcelo Macedo Rogero;Kevin Noel Keane;Rui Curi.
Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages.
P Newsholme;Rui Curi;S Gordon;E A Newsholme.
Biochemical Journal (1986)
Molecular mechanisms of ROS production and oxidative stress in diabetes.
Philip Newsholme;Vinicius Fernandes Cruzat;Vinicius Fernandes Cruzat;Kevin Noel Keane;Rodrigo Carlessi.
Biochemical Journal (2016)
Rates of utilization and fates of glucose, glutamine, pyruvate, fatty acids and ketone bodies by mouse macrophages
P Newsholme;S Gordon;E A Newsholme.
Biochemical Journal (1987)
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