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Philip Newsholme

Philip Newsholme

D-Index & Metrics

Biology and Biochemistry

D-Index
80
Citations
23624
World Ranking
4069
National Ranking
97

Overview

Philip Newsholme is affiliated with Curtin University in Australia and has contributed extensively to the fields of medicine, biochemistry, genetics, molecular biology, immunology, and microbiology. Their research spans various subfields, including immunology, molecular biology, physiology, surgery, and cell biology.

The scientist's work covers multiple main topics, reflecting a diverse research portfolio. These include:

  • Immune cells in cancer
  • Alzheimer's disease research and treatments
  • Immune cell function and interaction
  • Diet and metabolism studies
  • Immune response and inflammation
  • Endoplasmic reticulum stress and disease
  • Vitamin D research studies

Philip Newsholme has published research in several high-profile journals, with frequent appearances in the International Journal of Molecular Sciences. Other notable venues include Clinical Science, European Journal of Clinical Nutrition, Nutrients, and Pharmacological Research. Some recent papers by or associated with the scientist include:

  • Butyrate generated by gut microbiota and its therapeutic role in metabolic syndrome, 2020, Pharmacological Research
  • The Critical Role of Cell Metabolism for Essential Neutrophil Functions, 2020, Cellular Physiology and Biochemistry
  • Amylin and beta amyloid proteins interact to form amorphous heterocomplexes with enhanced toxicity in neuronal cells, 2020, Scientific Reports
  • Host cell glutamine metabolism as a potential antiviral target, 2021, Clinical Science
  • The Immunometabolic Roles of Various Fatty Acids in Macrophages and Lymphocytes, 2021, International Journal of Molecular Sciences

Frequent collaborators in their research include Rui Curi, Vínicius Fernandes Cruzat, Giuseppe Verdile, Stephanie C. Bridgeman, and Cyril Mamotte. These coauthors have collaborated on multiple publications, contributing to the breadth of research outputs linked to Philip Newsholme.

Best Publications

  • Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

    Seth L Masters;Aisling Dunne;Shoba L Subramanian;Rebecca L Hull

  • Glutamine: Metabolism and immune function, supplementation and clinical translation

    Vinicius Cruzat;Marcelo Macedo Rogero;Kevin Noel Keane;Rui Curi

  • Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity.

    P. Newsholme;E. P. Haber;S. M. Hirabara;E. L. O. Rebelato

  • Glutamine and glutamate—their central role in cell metabolism and function

    Philip Newsholme;Joaquim Procopio;Manuela Maria Ramos Lima;Tania Cristina Pithon-Curi

  • Molecular mechanisms of ROS production and oxidative stress in diabetes.

    Philip Newsholme;Vinicius Fernandes Cruzat;Vinicius Fernandes Cruzat;Kevin Noel Keane;Rodrigo Carlessi

  • Why Is l-Glutamine Metabolism Important to Cells of the Immune System in Health, Postinjury, Surgery or Infection?

    Philip Newsholme

  • Molecular mechanisms of glutamine action.

    R. Curi;C.J. Lagranha;S.Q. Doi;D.F. Sellitti

  • Glutamine and glutamate as vital metabolites

    P. Newsholme;M.M.R. Lima;J. Procopio;T.C. Pithon-Curi

  • Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages.

    P Newsholme;Rui Curi;S Gordon;E A Newsholme

  • Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's Disease.

    Giuseppe Verdile;Kevin N. Keane;Vinicius F. Cruzat;Sandra Medic

  • The Impact of Vitamin D Levels on Inflammatory Status: A Systematic Review of Immune Cell Studies

    Emily K. Calton;Kevin N. Keane;Philip Newsholme;Mario J. Soares

  • Rates of utilization and fates of glucose, glutamine, pyruvate, fatty acids and ketone bodies by mouse macrophages

    P Newsholme;S Gordon;E A Newsholme

  • Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and β-Cell Dysfunction.

    Kevin Noel Keane;Vinicius Fernandes Cruzat;Rodrigo Carlessi;Paulo Ivo Homem de Bittencourt

  • New insights into amino acid metabolism, β-cell function and diabetes

    Philip Newsholme;Lorraine Brennan;Blanca Rubi;Pierre Maechler

  • Effect of low-to-moderate amounts of dietary fish oil on neutrophil lipid composition and function.

    D. A. Healy;F. A. Wallace;E. A. Miles;P. C. Calder

  • Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line.

    D. Morgan;H. R. Oliveira-Emilio;D. Keane;A. E. Hirata

  • Regulation of SIRT1 in aging: Roles in mitochondrial function and biogenesis

    Yujia Yuan;Vinicius Fernandes Cruzat;Philip Newsholme;Jingqiu Cheng

  • Amino acid metabolism, insulin secretion and diabetes.

    P. Newsholme;K. Bender;A. Kiely;L. Brennan

  • Rates of utilization of glucose, glutamine and oleate and formation of end-products by mouse peritoneal macrophages in culture.

    P Newsholme;E A Newsholme

  • Nutrient regulation of insulin secretion and action

    Philip Newsholme;Vinicius Cruzat;Frank Arfuso;Kevin Noel Keane

Frequent Co-Authors

Rui Curi
Rui Curi Universidade de São Paulo
Peter R. Flatt
Peter R. Flatt University of Ulster
Frank Arfuso
Frank Arfuso University of Western Australia
Eric A. Newsholme
Eric A. Newsholme University of Oxford
Pierre Maechler
Pierre Maechler University of Geneva
Richard J. FitzGerald
Richard J. FitzGerald University of Limerick
Ralph N. Martins
Ralph N. Martins Edith Cowan University
Prue H. Hart
Prue H. Hart Telethon Kids Institute
Noel G. Morgan
Noel G. Morgan University of Exeter
Kevin M. Brindle
Kevin M. Brindle University of Cambridge

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