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Denise D. Belsham

Denise D. Belsham

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
9758
World Ranking
14576
National Ranking
513

Overview

Denise D. Belsham is affiliated with the University of Toronto in Canada and has established a significant body of research in medicine, neuroscience, and biochemistry, genetics, and molecular biology. Their work primarily focuses on endocrine and autonomic systems, physiology, cancer research, molecular biology, and reproductive medicine.

The scientist's research topics include:

  • Regulation of Appetite and Obesity
  • MicroRNA in disease regulation
  • Hypothalamic control of reproductive hormones
  • Circadian rhythm and melatonin
  • Adipose Tissue and Metabolism
  • Effects and risks of endocrine disrupting chemicals
  • Neuroinflammation and Neurodegeneration Mechanisms

Denise D. Belsham has published extensively in multiple academic venues, with frequent publications in:

  • Molecular and Cellular Endocrinology
  • Endocrinology
  • Journal of Neuroendocrinology
  • Journal of the Endocrine Society
  • Neuroendocrinology

Among the recent papers are:

  • Central Ceramide Signaling Mediates Obesity-Induced Precocious Puberty, 2020, Cell Metabolism
  • Palmitate differentially regulates Spexin, and its receptors Galr2 and Galr3, in GnRH neurons through mechanisms involving PKC, MAPKs, and TLR4, 2020, Molecular and Cellular Endocrinology
  • Hypothalamic reproductive neurons communicate through signal transduction to control reproduction, 2020, Molecular and Cellular Endocrinology
  • Insulin signalling in hypothalamic neurones, 2020, Journal of Neuroendocrinology
  • Analysis of Western diet, palmitate and BMAL1 regulation of neuropeptide Y expression in the murine hypothalamus and BMAL1 knockout cell models, 2020, Molecular and Cellular Endocrinology

The scientist has collaborated frequently with several coauthors, such as:

  • Neruja Loganathan
  • Wenyuan He
  • Emma K. McIlwraith
  • Andy C. Tran
  • Prasad S. Dalvi

Best Publications

  • Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity

    Sabrina Diano;Zhong Wu Liu;Jin Kwon Jeong;Marcelo O. Dietrich;Marcelo O. Dietrich

  • Palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons: rescue of resistance and apoptosis through adenosine 5' monophosphate-activated protein kinase activation.

    Christopher M. Mayer;Denise D. Belsham

  • 5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary.

    Tarang Khare;Shraddha Pai;Karolis Koncevicius;Karolis Koncevicius;Mrinal Pal

  • Estrogen receptor alpha and G-protein coupled receptor 30 mediate the neuroprotective effects of 17β-estradiol in novel murine hippocampal cell models

    S. Gingerich;G.L. Kim;J.A. Chalmers;M.M. Koletar

  • Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model

    Viviane Labrie;Ryutaro Fukumura;Anjali Rastogi;Laura J. Fick

  • Day/night rhythms in gene expression of the normal murine heart.

    Tami Martino;Sara Arab;Marty Straume;Denise D. Belsham

  • Ciliary neurotrophic factor recruitment of glucagon-like peptide-1 mediates neurogenesis, allowing immortalization of adult murine hypothalamic neurons

    Denise D. Belsham;Laura J. Fick;Prasad S. Dalvi;Maria-Luisa Centeno

  • Functional Cross-modulation between SOCS Proteins Can Stimulate Cytokine Signaling

    Julie Piessevaux;Delphine Lavens;Tony Montoye;Joris Wauman

  • Activation of the omega-3 fatty acid receptor GPR120 mediates anti-inflammatory actions in immortalized hypothalamic neurons

    Leigh Wellhauser;Denise D Belsham;Denise D Belsham

  • Phoenixin Activates Immortalized GnRH and Kisspeptin Neurons Through the Novel Receptor GPR173

    Alice K. Treen;Vicky Luo;Denise D. Belsham

  • Transcription Factors Oct-1 and C/EBPβ (CCAAT/Enhancer-Binding Protein-β) Are Involved in the Glutamate/Nitric Oxide/cyclic-Guanosine 5′-Monophosphate-Mediated Repression of Gonadotropin-Releasing Hormone Gene Expression

    Denise D. Belsham;Pamela L. Mellon

  • A Neuron-Specific Enhancer Targets Expression of the Gonadotropin-Releasing Hormone Gene to Hypothalamic Neurosecretory Neurons

    David B. Whyte;Mark A. Lawson;Denise D. Belsham;Satish A. Eraly

  • Essential Role of Pten in Body Size Determination and Pancreatic β-Cell Homeostasis In Vivo

    Kinh-Tung T. Nguyen;Panteha Tajmir;Chia Hung Lin;Nicole Liadis

  • Insulin directly regulates NPY and AgRP gene expression via the MAPK MEK/ERK signal transduction pathway in mHypoE-46 hypothalamic neurons.

    Christopher M. Mayer;Denise D. Belsham;Denise D. Belsham

  • The generation of an array of clonal, immortalized cell models from the rat hypothalamus: analysis of melatonin effects on kisspeptin and gonadotropin-inhibitory hormone neurons

    S. Gingerich;X. Wang;P.K.P. Lee;S.S. Dhillon

  • Teneurin proteins possess a carboxy terminal sequence with neuromodulatory activity.

    Liqun Wang;Susan Rotzinger;Arij Al Chawaf;Carol F. Elias

  • Eliminating SF-1 (NR5A1) Sumoylation In Vivo Results in Ectopic Hedgehog Signaling and Disruption of Endocrine Development

    Florence Y. Lee;Emily J. Faivre;Miyuki Suzawa;Erik Lontok

  • Leptin signaling in neurotensin neurons involves STAT, MAP kinases ERK1/2, and p38 through c-Fos and ATF1.

    Hong Cui;Fang Cai;Denise D. Belsham

  • NMDA and nitric oxide act through the cGMP signal transduction pathway to repress hypothalamic gonadotropin-releasing hormone gene expression.

    D. D. Belsham;W. C. Wetsel;P. L. Mellon

  • Estrogen Facilitates both Phosphatidylinositol 3-Kinase/Akt and ERK1/2 Mitogen-Activated Protein Kinase Membrane Signaling Required for Long-Term Neuropeptide Y Transcriptional Regulation in Clonal, Immortalized Neurons

    Danny Titolo;Christopher M. Mayer;Sandeep S. Dhillon;Fang Cai

Frequent Co-Authors

Manuel Tena-Sempere
Manuel Tena-Sempere University of Córdoba
Martin R. Ralph
Martin R. Ralph University of Toronto
Leonor Pinilla
Leonor Pinilla University of Córdoba
Peter Liu
Peter Liu University of Ottawa
Michael B. Wheeler
Michael B. Wheeler University of Toronto
Juan Carlos Roa
Juan Carlos Roa University of Córdoba
Peter H. Backx
Peter H. Backx York University
Michael Wilkinson
Michael Wilkinson Dalhousie University
Michael O. Thompson
Michael O. Thompson Cornell University
Dalia Barsyte-Lovejoy
Dalia Barsyte-Lovejoy Structural Genomics Consortium

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