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Biology and Biochemistry

D-Index
76
Citations
59113
World Ranking
4907
National Ranking
366

Research.com Recognitions

  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom

Overview

Kinya Otsu is affiliated with King's College London in the United Kingdom and has contributed extensively to the fields of medicine and biochemistry, genetics, and molecular biology. Their research predominantly explores molecular biology, epidemiology, immunology, hematology, and cardiology and cardiovascular medicine.

The scientist's work covers several key topics including autophagy in disease and therapy, iron metabolism and disorders, extracellular vesicles in disease, viral infections and immunology research, signaling pathways in disease, RNA research and splicing, and cytokine signaling pathways and interactions.

Notable recent publications by Kinya Otsu include:

  • Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice, 2021, eLife
  • NLRP3 inflammasome-driven IL-1β and IL-18 contribute to lipopolysaccharide-induced septic cardiomyopathy, 2023, Journal of Molecular and Cellular Cardiology
  • Cytokine mRNA Degradation in Cardiomyocytes Restrains Sterile Inflammation in Pressure-Overloaded Hearts, 2020, Circulation
  • The kinase p38α functions in dendritic cells to regulate Th2-cell differentiation and allergic inflammation, 2022, Cellular and Molecular Immunology
  • NF-κB activation in cardiac fibroblasts results in the recruitment of inflammatory Ly6C hi monocytes in pressure-overloaded hearts, 2021, Science Signaling

Kinya Otsu has frequently collaborated with several other researchers, including:

  • Shigemiki Omiya
  • Tomokazu Murakawa
  • Manabu Taneike
  • Jumpei Ito
  • Kazuhiko Nishida

The scientist's work has appeared repeatedly in prominent scientific venues such as:

  • European Heart Journal
  • Scientific Reports
  • Journal of Molecular and Cellular Cardiology
  • Journal of Biological Chemistry
  • eLife

Kinya Otsu has been recognized as a Fellow of The Academy of Medical Sciences in the United Kingdom.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

    Hiroki Kato;Osamu Takeuchi;Shintaro Sato;Mitsutoshi Yoneyama

  • Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

    Takashi Nakagawa;Shigeomi Shimizu;Tetsuya Watanabe;Osamu Yamaguchi

  • Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia

    J Fujii;K Otsu;F Zorzato;S de Leon

  • The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress.

    Atsuko Nakai;Osamu Yamaguchi;Toshihiro Takeda;Yoshiharu Higuchi

  • Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

    Takafumi Oka;Shungo Hikoso;Osamu Yamaguchi;Manabu Taneike;Manabu Taneike

  • Discovery of Atg5/Atg7-independent alternative macroautophagy

    Yuya Nishida;Satoko Arakawa;Kenji Fujitani;Hirofumi Yamaguchi

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Direct Association of the Gap Junction Protein Connexin-43 with ZO-1 in Cardiac Myocytes

    Toshihiko Toyofuku;Masanori Yabuki;Kinya Otsu;Tsunehiko Kuzuya

  • Inhibition of autophagy in the heart induces age-related cardiomyopathy.

    Manabu Taneike;Osamu Yamaguchi;Atsuko Nakai;Shungo Hikoso

  • Exercise Provides Direct Biphasic Cardioprotection via Manganese Superoxide Dismutase Activation

    Nobushige Yamashita;Shiro Hoshida;Kinya Otsu;Michio Asahi

  • The role of autophagy in the heart

    Kazuhiko Nishida;S. Kyoi;O. Yamaguchi;J. Sadoshima

  • Involvement of Nuclear Factor-κB and Apoptosis Signal-Regulating Kinase 1 in G-Protein–Coupled Receptor Agonist–Induced Cardiomyocyte Hypertrophy

    Shinichi Hirotani;Kinya Otsu;Kazuhiko Nishida;Yoshiharu Higuchi

  • Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation.

    Tomokazu Murakawa;Osamu Yamaguchi;Ayako Hashimoto;Shungo Hikoso

  • Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload

    Norifumi Takeda;Ichiro Manabe;Yuichi Uchino;Kosei Eguchi

  • A substitution of cysteine for arginine 614 in the ryanodine receptor is potentially causative of human malignant hyperthermia.

    Elizabeth F. Gillard;Kinya Otsu;Junichi Fujii;Vijay K. Khanna

  • Crosstalk Between Autophagy and Apoptosis in Heart Disease

    Kazuhiko Nishida;Osamu Yamaguchi;Kinya Otsu

  • Signaling Pathways and Genes that Inhibit Pathogen-Induced Macrophage Apoptosis— CREB and NF-κB as Key Regulators

    Jin Mo Park;Florian R. Greten;Athena Wong;Randal J. Westrick

Frequent Co-Authors

Masatsugu Hori
Masatsugu Hori Osaka University
Issei Komuro
Issei Komuro University of Tokyo
Ajay M. Shah
Ajay M. Shah King's College London
Shigeomi Shimizu
Shigeomi Shimizu Tokyo Medical and Dental University
Noboru Mizushima
Noboru Mizushima University of Tokyo
Sergio Lavandero
Sergio Lavandero University of Chile
Takashi Morita
Takashi Morita Meiji Pharmaceutical University
Evelina Gatti
Evelina Gatti Aix-Marseille University
Boris Zhivotovsky
Boris Zhivotovsky Karolinska Institute
Ichiro Manabe
Ichiro Manabe Chiba University

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