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Medicine

D-Index
102
Citations
58007
World Ranking
7510
National Ranking
3921

Overview

Mark D. Fleming is affiliated with Boston Children's Hospital in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions in Molecular Biology, Genetics, Hematology, Pediatrics, Perinatology and Child Health, and Epidemiology. This broad range informs their studies on various genetic and hematologic conditions.

The scientist's recent publications cover topics related to genetic pathways, epigenetics, immune response, and hematologic complications. Notable papers include:

  • Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome (2021, Nature Communications)
  • Novel diagnostic DNA methylation episignatures expand and refine the epigenetic landscapes of Mendelian disorders (2021, Human Genetics and Genomics Advances)
  • Hepcidin-Mediated Hypoferremia Disrupts Immune Responses to Vaccination and Infection (2020, Med)
  • Functional correlation of genome-wide DNA methylation profiles in genetic neurodevelopmental disorders (2022, Human Mutation)
  • Hematologic complications with age in Shwachman-Diamond syndrome (2021, Blood Advances)

Frequent co-authors in Fleming's work include Sarah Ducamp, Dean R. Campagna, Akiko Shimamura, Paul J. Schmidt, and Sioḃán Keel, indicating collaboration across multiple research clusters.

The scholar's publication record features contributions to venues such as Blood, bioRxiv (Cold Spring Harbor Laboratory), American Journal of Hematology, Human Genetics and Genomics Advances, and Human Mutation. These journals reflect a focus on hematologic and genetic research.

Research topics covered by Fleming frequently address biochemical and clinical aspects of blood and metabolism, with main topics including:

  • Porphyrin Metabolism and Disorders
  • Iron Metabolism and Disorders
  • Heme Oxygenase-1 and Carbon Monoxide
  • Blood disorders and treatments
  • Folate and B Vitamins Research
  • Hemoglobinopathies and Related Disorders
  • Mitochondrial Function and Pathology

Overall, the work of Mark D. Fleming centers on advancing understanding of genetic and hematologic mechanisms and their clinical implications, with a focus on metabolic pathways and pediatric hematology.

Best Publications

  • Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy

    Howard I. Scher;Karim Fizazi;Fred Saad;Mary-Ellen Taplin

  • Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: A single-arm, multicentre, phase 2 trial

    Jonathan E Rosenberg;Jean Hoffman-Censits;Tom Powles;Michiel S van der Heijden

  • The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

    Heather R. Christofk;Matthew G. Vander Heiden;Marian H. Harris;Arvind Ramanathan

  • p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities.

    Annie Yang;Mourad Kaghad;Yunmei Wang;Emily Gillett

  • Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

    Adriana Donovan;Alison Brownlie;Alison Brownlie;Yi Zhou;Jennifer Shepard

  • Regulation of progenitor cell proliferation and granulocyte function by microRNA-223

    Jonathan B. Johnnidis;Marian H. Harris;Robert T. Wheeler;Sandra Stehling-Sun

  • Recurrent BRAF mutations in Langerhans cell histiocytosis

    Gayane Badalian-Very;Gayane Badalian-Very;Jo-Anne Vergilio;Jo-Anne Vergilio;Barbara A. Degar;Barbara A. Degar;Laura E. MacConaill

  • Erdafitinib in Locally Advanced or Metastatic Urothelial Carcinoma

    Y. Loriot;A. Necchi;S. H. Park;J. Garcia-Donas

  • Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells

    Brian Elenbaas;Lisa Spirio;Frederick Koerner;Mark D. Fleming

  • Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease

    David A. Weinstein;Cindy N. Roy;Mark D. Fleming;Massimo F. Loda

  • Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells.

    Robert S Ohgami;Dean R Campagna;Eric L Greer;Brendan Antiochos

  • Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts.

    Merav Socolovsky;Hyung-song Nam;Mark D. Fleming;Volker H. Haase

  • Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA).

    Karin E Finberg;Matthew M Heeney;Matthew M Heeney;Dean R Campagna;Yeşim Aydınok

  • The Steap proteins are metalloreductases

    Robert S. Ohgami;Robert S. Ohgami;Dean R. Campagna;Dean R. Campagna;Alice McDonald;Alice McDonald;Mark D. Fleming;Mark D. Fleming

  • Myelopoiesis in the zebrafish, Danio rerio

    Carolyn M. Bennett;Carolyn M. Bennett;Carolyn M. Bennett;John P. Kanki;John P. Kanki;John P. Kanki;Jennifer Rhodes;Jennifer Rhodes;Jennifer Rhodes;Ting X. Liu;Ting X. Liu;Ting X. Liu

  • Telomerase contributes to tumorigenesis by a telomere length-independent mechanism

    Sheila A. Stewart;William C. Hahn;Benjamin F. O'Connor;Elisa N. Banner

  • The genomic landscape of pediatric Ewing sarcoma

    Brian D. Crompton;Chip Stewart;Amaro Taylor-Weiner;Gabriela Alexe

  • Measuring safety climate on offshore installations

    Kathryn Mearns;Rhona Flin;Rachale Gordon;Mark Fleming

  • Pembrolizumab alone or combined with chemotherapy versus chemotherapy as first-line therapy for advanced urothelial carcinoma (KEYNOTE-361): a randomised, open-label, phase 3 trial.

    Thomas Powles;Thomas Powles;Tibor Csőszi;Mustafa Özgüroğlu;Nobuaki Matsubara

  • Heme-regulated eIF2α kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency

    An-Ping Han;Channing Yu;Linrong Lu;Yuko Fujiwara

Frequent Co-Authors

Peter Gloviczki
Peter Gloviczki Mayo Clinic
Thomas C. Bower
Thomas C. Bower Mayo Clinic
Nancy C. Andrews
Nancy C. Andrews Duke University
Benjamin L. Ebert
Benjamin L. Ebert Harvard University
Akiko Shimamura
Akiko Shimamura Harvard University
Geraldine S. Pinkus
Geraldine S. Pinkus Brigham and Women's Hospital
Neal D. Shore
Neal D. Shore Carolina Urologic Research Center
Catherine J. Wu
Catherine J. Wu Harvard University
Donna Neuberg
Donna Neuberg Harvard University

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