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Immunology

D-Index
48
Citations
9217
World Ranking
4427
National Ranking
2010

Overview

Timothy L. Denning is affiliated with the Georgia Research Alliance in the United States and has a research focus primarily in the fields of Immunology and Microbiology, Medicine, and Biochemistry, Genetics and Molecular Biology. Their scientific work spans multiple subfields, including Immunology, Molecular Biology, Epidemiology, Genetics, and Dermatology.

Their research addresses a variety of topics, with notable coverage in:

  • Psoriasis: Treatment and Pathogenesis
  • Epigenetics and DNA Methylation
  • Immune Cell Function and Interaction
  • Immune Response and Inflammation
  • Gut microbiota and health
  • Dermatology and Skin Diseases
  • Immunotherapy and Immune Responses

Denning's published works include articles in several frequent venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Immunology
  • ACS Omega
  • Mucosal Immunology

Some of the recent publications by Timothy L. Denning include:

  • "PTH induces bone loss via microbial-dependent expansion of intestinal TNF+ T cells and Th17 cells", 2020, Nature Communications
  • "Internalization of Garlic-Derived Nanovesicles on Liver Cells is Triggered by Interaction With CD98", 2020, ACS Omega
  • "IL-36 cytokines and gut immunity", 2021, Immunology
  • "Erythroid differentiation regulator-1 induced by microbiota in early life drives intestinal stem cell proliferation and regeneration", 2020, Nature Communications
  • "Self and microbiota-derived epitopes induce CD4+ T cell anergy and conversion into CD4+Foxp3+ regulatory cells", 2020, Mucosal Immunology

The scientist collaborates frequently with several co-authors, including:

  • Vu L. Ngo
  • Andrew T. Gewirtz
  • Michal Kuczma
  • Hirohito Abo
  • Yuning Hou

Best Publications

  • Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses.

    Timothy L Denning;Yi-chong Wang;Seema R Patel;Ifor R Williams

  • Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance

    Stephanie Dillon;Sudhanshu Agrawal;Kaustuv Banerjee;John Letterio

  • Functional Specializations of Intestinal Dendritic Cell and Macrophage Subsets That Control Th17 and Regulatory T Cell Responses Are Dependent on the T Cell/APC Ratio, Source of Mouse Strain, and Regional Localization

    Timothy L. Denning;Brian A. Norris;Oscar Medina-Contreras;Santhakumar Manicassamy

  • Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota

    Anna Cebula;Michal Seweryn;Michal Seweryn;Grzegorz A. Rempala;Simarjot Singh Pabla

  • Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity.

    Santhakumar Manicassamy;Rajesh Ravindran;Jiusheng Deng;Herold Oluoch

  • CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation and colitogenic TH17 responses in mice

    Oscar Medina-Contreras;Duke Geem;Oskar Laur;Ifor R Williams

  • CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice

    Oscar Medina-Contreras;Duke Geem;Oskar Laur;Ifor R. Williams

  • Wound repair: role of immune–epithelial interactions

    G. Leoni;P. A. Neumann;R. Sumagin;T. L. Denning

  • Prevention and cure of rotavirus infection via TLR5/NLRC4–mediated production of IL-22 and IL-18

    Benyue Zhang;Benoit Chassaing;Zhenda Shi;Robin Uchiyama

  • Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling

    Miguel Quiros;Hikaru Nishio;Philipp A Neumann;Dorothee Siuda

  • Division of labor, plasticity, and crosstalk between dendritic cell subsets

    Bali Pulendran;Hua Tang;Timothy L. Denning

  • ERK1-/- mice exhibit Th1 cell polarization and increased susceptibility to experimental autoimmune encephalomyelitis.

    Anshu Agrawal;Stephanie Dillon;Timothy L. Denning;Bali Pulendran

  • Mouse TCRαβ+CD8αα Intraepithelial Lymphocytes Express Genes That Down-Regulate Their Antigen Reactivity and Suppress Immune Responses

    Timothy L. Denning;Steve Granger;Daniel Mucida;Ryan Graddy

  • Pulmonary antigen encounter regulates the establishment of tissue-resident CD8 memory T cells in the lung airways and parenchyma.

    Sean R. McMaster;Alexander N. Wein;Paul R. Dunbar;Sarah L. Hayward

  • Differential Induction of Interleukin-10 and Interleukin-12 in Dendritic Cells by Microbial Toll-Like Receptor Activators and Skewing of T-Cell Cytokine Profiles

    Hai Qi;Timothy L. Denning;Lynn Soong

  • Oxidative stress induces the expression of Fas and Fas ligand and apoptosis in murine intestinal epithelial cells.

    Timothy L Denning;Hiromasa Takaishi;Sheila E Crowe;Istvan Boldogh

  • Fab’-bearing siRNA TNFα-loaded nanoparticles targeted to colonic macrophages offer an effective therapy for experimental colitis

    Hamed Laroui;Emilie Viennois;Bo Xiao;Brandon S.B. Canup

  • Cutting Edge: CD4+CD25+ Regulatory T Cells Impaired for Intestinal Homing Can Prevent Colitis

    Timothy L. Denning;Gisen Kim;Mitchell Kronenberg

  • Hepatic Stellate Cells Preferentially Induce Foxp3+ Regulatory T Cells by Production of Retinoic Acid

    Richard M. Dunham;Manoj Thapa;Victoria M. Velazquez;Elizabeth J. Elrod

  • Negative selection of T cells by Helicobacter pylori as a model for bacterial strain selection by immune evasion.

    Jide Wang;Edward G. Brooks;Kathleen B. Bamford;Timothy L. Denning

  • IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria

    K L Flannigan;K L Flannigan;V L Ngo;D Geem;D Geem;A Harusato

  • Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage.

    Oscar Medina-Contreras;Akihito Harusato;Hikaru Nishio;Kyle L. Flannigan

  • Compromised Intestinal Epithelial Barrier Induces Adaptive Immune Compensation that Protects from Colitis

    Manirath Khounlotham;Wooki Kim;Eric Peatman;Porfirio Nava

Frequent Co-Authors

Asma Nusrat
Asma Nusrat University of Michigan–Ann Arbor
Charles A. Parkos
Charles A. Parkos University of Michigan–Ann Arbor
Andrew T. Gewirtz
Andrew T. Gewirtz Georgia State University
Didier Merlin
Didier Merlin Georgia State University
Peter B. Ernst
Peter B. Ernst University of California, San Diego
Bali Pulendran
Bali Pulendran Stanford University
Benoit Chassaing
Benoit Chassaing Georgia State University
Ifor R. Williams
Ifor R. Williams Emory University
Shanthi V. Sitaraman
Shanthi V. Sitaraman Emory University
Sheila E. Crowe
Sheila E. Crowe University of California, San Diego

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