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Neuroscience

D-Index
47
Citations
12450
World Ranking
6323
National Ranking
2754

Overview

Teresa G. Hastings is affiliated with the University of Pittsburgh in the United States. Their research primarily focuses on mechanisms related to neurodegenerative diseases, with particular emphasis on Parkinson's disease. The scientific output encompasses various aspects of neurology, cellular and molecular neuroscience, molecular biology, physiology, and immunology.

Their work spans several core topics, including:

  • Parkinson's Disease Mechanisms and Treatments
  • Nerve injury and regeneration
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Alzheimer's disease research and treatments
  • Nuclear Receptors and Signaling
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Ferroptosis and cancer prognosis

Teresa G. Hastings has published extensively, with notable recent papers including:

  • "Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal" (2021) published in Nature Chemical Biology
  • "Transient exposure to rotenone causes degeneration and progressive parkinsonian motor deficits, neuroinflammation, and synucleinopathy" (2023) published in npj Parkinson's Disease
  • "Acquired dysregulation of dopamine homeostasis reproduces features of Parkinson's disease" (2020) published in npj Parkinson's Disease
  • "α-Synuclein amplifies cytoplasmic peroxide flux and oxidative stress provoked by mitochondrial inhibitors in CNS dopaminergic neurons in vivo" (2020) published in Redox Biology
  • "NADPH oxidase 2 activity in Parkinson's disease" (2022) published in Neurobiology of Disease

Frequent publication venues for their research include:

  • npj Parkinson's Disease
  • Nature Chemical Biology
  • Science Translational Medicine
  • Redox Biology
  • Neurobiology of Disease

Collaboration is a significant part of their scientific activity. Their frequent co-authors are:

  • J. Timothy Greenamyre
  • Matthew T. Keeney
  • Edward A. Burton
  • Alevtina Zharikov
  • Emily M. Rocha

Their publications span across the fields of medicine and neuroscience, with strong contributions to neurology and cellular and molecular neuroscience. The research themes address complex biochemical and cellular pathways underlying neurodegeneration, with a particular focus on oxidative stress, dopaminergic neuron health, and neuroinflammatory processes related to Parkinson's disease and other neurodegenerative conditions.

Best Publications

  • Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation

    IJ Reynolds;TG Hastings

  • Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: implications for Parkinson's disease.

    Sarah B. Berman;Teresa G. Hastings

  • Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections.

    Teresa G. Hastings;David A. Lewis;Michael J. Zigmond

  • α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

    Roberto Di Maio;Paul J. Barrett;Eric K. Hoffman;Caitlyn W. Barrett

  • Cytotoxic and genotoxic potential of dopamine

    Alan H. Stokes;Teresa G. Hastings;Kent E. Vrana

  • LRRK2 activation in idiopathic Parkinson’s disease

    Roberto Di Maio;Eric K. Hoffman;Emily M. Rocha;Matthew T. Keeney

  • Parkinson's--Divergent Causes, Convergent Mechanisms

    J. Timothy Greenamyre;Teresa G. Hastings

  • Dopamine Quinone Formation and Protein Modification Associated with the Striatal Neurotoxicity of Methamphetamine: Evidence against a Role for Extracellular Dopamine

    Matthew J. LaVoie;Teresa G. Hastings

  • Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism

    David N. Hauser;Teresa G. Hastings

  • Enzymatic Oxidation of Dopamine: The Role of Prostaglandin H Synthase

    Teresa G. Hastings

  • Methamphetamine-induced degeneration of dopaminergic neurons involves autophagy and upregulation of dopamine synthesis.

    Kristin E. Larsen;Edward A. Fon;Teresa G. Hastings;Robert H. Edwards

  • Unregulated Cytosolic Dopamine Causes Neurodegeneration Associated with Oxidative Stress in Mice

    Linan Chen;Yunmin Ding;Barbara Cagniard;Amber D Van Laar

  • Estimating hydroxyl radical content in rat brain using systemic and intraventricular salicylate: impact of methamphetamine.

    Andrew Giovanni;Li Ping Liang;Teresa G. Hastings;Michael J. Zigmond

  • Microglial activation precedes dopamine terminal pathology in methamphetamine-induced neurotoxicity.

    Matthew J. LaVoie;J.Patrick Card;Teresa G. Hastings

  • The role of dopamine oxidation in mitochondrial dysfunction: implications for Parkinson’s disease

    Teresa G. Hastings

  • Identification of Catechol-Protein Conjugates in Neostriatal Slices Incubated with [3H]Dopamine: Impact of Ascorbic Acid and Glutathione

    Teresa G. Hastings;Michael J. Zigmond

  • Modification of dopamine transporter function : Effect of reactive oxygen species and dopamine

    Sarah B. Berman;Michael J. Zigmond;Teresa G. Hastings

  • Leptin protects against 6-hydroxydopamine-induced dopaminergic cell death via mitogen-activated protein kinase signaling.

    Zhongfang Weng;Armando P. Signore;Yanqing Gao;Suping Wang

  • shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson’s disease model

    Alevtina D. Zharikov;Alevtina D. Zharikov;Jason R. Cannon;Jason R. Cannon;Jason R. Cannon;Victor Tapias;Qing Bai

  • Peroxynitrite- and nitrite-induced oxidation of dopamine: implications for nitric oxide in dopaminergic cell loss.

    Matthew J. LaVoie;Teresa G. Hastings

  • Could a loss of α‐synuclein function put dopaminergic neurons at risk?

    Ruth G. Perez;Teresa G. Hastings

  • Peroxiredoxin-2 Protects against 6-Hydroxydopamine-Induced Dopaminergic Neurodegeneration via Attenuation of the Apoptosis Signal-Regulating Kinase (ASK1) Signaling Cascade

    X. Hu;Z. Weng;C. T. Chu;L. Zhang

Frequent Co-Authors

Michael J. Zigmond
Michael J. Zigmond University of Pittsburgh
Makoto Higuchi
Makoto Higuchi National Institutes for Quantum and Radiological Science and Technology
Tetsuya Suhara
Tetsuya Suhara National Institutes for Quantum and Radiological Science and Technology
David A. Lewis
David A. Lewis University of Pittsburgh
Elizabeth D. Abercrombie
Elizabeth D. Abercrombie Rutgers, The State University of New Jersey
David Sulzer
David Sulzer Columbia University
J. Patrick Card
J. Patrick Card University of Pittsburgh
Xiaoming Hu
Xiaoming Hu University of Pittsburgh
Un Jung Kang
Un Jung Kang New York University
Robert H. Edwards
Robert H. Edwards University of California, San Francisco

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