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Biology and Biochemistry

D-Index
61
Citations
9817
World Ranking
11615
National Ranking
4999

Overview

Donald M. Kuhn is affiliated with Wayne State University in the United States. Their research activity spans the fields of Medicine, Neuroscience, and Biochemistry, Genetics and Molecular Biology, with a strong emphasis on molecular biology and physiology. The scientist's work integrates aspects of biological psychiatry, endocrine and autonomic systems, and cellular and molecular neuroscience.

Their primary research topics include gut microbiota and health, tryptophan and brain disorders, diet and metabolism studies, as well as neuroscience of respiration and sleep. Additional focus areas include sleep and wakefulness research, obstructive sleep apnea research, and the influence of neurotransmitter receptors on behavior.

Donald M. Kuhn has published extensively in several scientific journals, frequently contributing to:

  • The FASEB Journal
  • Scientific Reports
  • Pharmacological Reviews
  • PLoS ONE
  • Physiological Reports

Some of their notable recent papers are:

  • "Repetitive, mild traumatic brain injury results in a progressive white matter pathology, cognitive deterioration, and a transient gut microbiota dysbiosis" (2020, Scientific Reports)
  • "Evidence for Modulation of Substance Use Disorders by the Gut Microbiome: Hidden in Plain Sight" (2021, Pharmacological Reviews)
  • "Differential effects of synthetic psychoactive cathinones and amphetamine stimulants on the gut microbiome in mice" (2020, PLoS ONE)
  • "Effects of a high fat diet on gut microbiome dysbiosis in a mouse model of Gulf War Illness" (2020, Scientific Reports)
  • "The effect of brain serotonin deficiency on breathing is magnified by age" (2022, Physiological Reports)

Collaborations are a significant aspect of their scientific output. Frequent co-authors of Donald M. Kuhn include:

  • Mariana Angoa-Pérez
  • Branislava Zagorac
  • Kevin R. Theis
  • Dina M. Francescutti
  • Andrew D. Winters

Their research contributions address complex interactions between neurobiology, microbiota, and metabolic influences, supported by interdisciplinary approaches across neuroscience and medicine.

Best Publications

  • Marble burying and nestlet shredding as tests of repetitive, compulsive-like behaviors in mice.

    Mariana Angoa-Pérez;Michael J. Kane;Denise I. Briggs;Dina M. Francescutti

  • A mouse model of human repetitive mild traumatic brain injury

    Michael J. Kane;Mariana Angoa-Pérez;Mariana Angoa-Pérez;Denise I. Briggs;Denise I. Briggs;David C. Viano

  • Review of the role of the central serotonergic neuronal system in blood pressure regulation.

    D M Kuhn;W A Wolf;W Lovenberg

  • Microglial activation is a pharmacologically specific marker for the neurotoxic amphetamines.

    David M. Thomas;Jennifer Dowgiert;Timothy J. Geddes;Timothy J. Geddes;Dina Francescutti-Verbeem

  • Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin

    Dawn N. Albertson;Barb Pruetz;Carl J. Schmidt;Donald M. Kuhn

  • Tyrosine hydroxylase is inactivated by catechol-quinones and converted to a redox-cycling quinoprotein: possible relevance to Parkinson's disease.

    Donald M. Kuhn;Robert E. Arthur;David M. Thomas;Lisa A. Elferink

  • MK-801 and dextromethorphan block microglial activation and protect against methamphetamine-induced neurotoxicity.

    David M. Thomas;Donald M. Kuhn;Donald M. Kuhn

  • Differential tissue distribution of tryptophan hydroxylase isoforms 1 and 2 as revealed with monospecific antibodies.

    Stacey A. Sakowski;Timothy J. Geddes;Timothy J. Geddes;David M. Thomas;David M. Thomas;Edi Levi

  • Potential mechanisms underlying anxiety and depression in Parkinson's disease: consequences of l-DOPA treatment.

    Karen L. Eskow Jaunarajs;Mariana Angoa-Perez;Donald M. Kuhn;Christopher Bishop

  • Mice Genetically Depleted of Brain Serotonin Display Social Impairments, Communication Deficits and Repetitive Behaviors: Possible Relevance to Autism

    Michael J. Kane;Mariana Angoa-Peréz;Mariana Angoa-Peréz;Denise I. Briggs;Denise I. Briggs;Catherine E. Sykes;Catherine E. Sykes

  • The newly synthesized pool of dopamine determines the severity of methamphetamine-induced neurotoxicity.

    David M. Thomas;Dina M. Francescutti-Verbeem;Dina M. Francescutti-Verbeem;Donald M. Kuhn;Donald M. Kuhn

  • Serotonin neurochemistry revisited: A new look at some old axioms

    Donald M. Kuhn;William A. Wolf;Moussa B.H. Youdim

  • Peroxynitrite Inactivation of Tyrosine Hydroxylase: Mediation by Sulfhydryl Oxidation, not Tyrosine Nitration

    Donald M. Kuhn;Cheryl W. Aretha;Timothy J. Geddes

  • Tryptophan hydroxylase. The role of oxygen, iron, and sulfhydryl groups as determinants of stability and catalytic activity.

    D.M. Kuhn;B. Ruskin;W. Lovenberg

  • Dopamine quinones activate microglia and induce a neurotoxic gene expression profile: relationship to methamphetamine-induced nerve ending damage.

    Donald M Kuhn;Dina M Francescutti-Verbeem;David M Thomas

  • Peroxynitrite inactivates the human dopamine transporter by modification of cysteine 342: potential mechanism of neurotoxicity in dopamine neurons.

    Samuel U. Park;Jasmine V. Ferrer;Jonathan A. Javitch;Donald M. Kuhn;Donald M. Kuhn

  • Genetic depletion of brain 5HT reveals a common molecular pathway mediating compulsivity and impulsivity

    Mariana Angoa-Pérez;Michael J. Kane;Michael J. Kane;Denise I. Briggs;Denise I. Briggs;Catherine E. Sykes;Catherine E. Sykes

  • Dopamine Inactivates Tryptophan Hydroxylase and Forms a Redox-Cycling Quinoprotein: Possible Endogenous Toxin to Serotonin Neurons

    Donald M. Kuhn;Robert Arthur

  • Identification of differentially regulated transcripts in mouse striatum following methamphetamine treatment--an oligonucleotide microarray approach.

    David M. Thomas;David M. Thomas;Dina M. Francescutti-Verbeem;Xiuli Liu;Donald M. Kuhn;Donald M. Kuhn

  • Attenuated microglial activation mediates tolerance to the neurotoxic effects of methamphetamine.

    David M. Thomas;Donald M. Kuhn;Donald M. Kuhn

Frequent Co-Authors

David Crich
David Crich University of Georgia
Christopher Bishop
Christopher Bishop Binghamton University
Marc D. Basson
Marc D. Basson University of North Dakota
Jonathan A. Javitch
Jonathan A. Javitch Columbia University
David R. Rosenberg
David R. Rosenberg Wayne State University
José A. Rafols
José A. Rafols Wayne State University
Richelle Mychasiuk
Richelle Mychasiuk Monash University
Curtis G. Wilkerson
Curtis G. Wilkerson Michigan State University
Linda D. Hazlett
Linda D. Hazlett Wayne State University
Shannon D. Manning
Shannon D. Manning Michigan State University

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