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Microbiology

D-Index
59
Citations
12121
World Ranking
3276
National Ranking
243

Overview

Martin Messerle is affiliated with Hannover Medical School in Germany. Their research primarily focuses on virology and immunology, with a strong emphasis on cytomegalovirus (CMV) and herpesvirus biology.

Their recent work includes publications in notable journals, addressing topics such as adaptive T cell responses, viral immune evasion mechanisms, and transplant immunology. Key papers include:

  • A CMV-induced adaptive human Vδ1+ γδ T cell clone recognizes HLA-DR, 2022, The Journal of Experimental Medicine
  • The Cytomegalovirus Tegument Protein UL35 Antagonizes Pattern Recognition Receptor-Mediated Type I IFN Transcription, 2020, Microorganisms
  • Differential effects of Belatacept on virus-specific memory versus de novo allo-specific T cell responses of kidney transplant recipients and healthy donors, 2020, Transplant Immunology
  • Repertoire characterization and validation of gB-specific human IgGs directly cloned from humanized mice vaccinated with dendritic cells and protected against HCMV, 2020, PLoS Pathogens
  • Assembly of infectious Kaposi's sarcoma-associated herpesvirus progeny requires formation of a pORF19 pentamer, 2021, PLoS Biology

The primary fields of study related to Messerle's work include Medicine and Immunology and Microbiology. They have contributed extensively to the subfields of Epidemiology, Immunology, Molecular Biology, Oncology, and Neurology.

The main topics covered by Messerle's research encompass:

  • Cytomegalovirus and herpesvirus research
  • Immune Cell Function and Interaction
  • Herpesvirus Infections and Treatments
  • T-cell and B-cell Immunology
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Immunotherapy and Immune Responses
  • Interferon and immune responses

Their frequent collaborators include Karen Wagner, Yvonne Lueder, Reinhold Förster, Eva Maria Borst, and Luka Čičin-Šain.

Messerle has published multiple articles in specialized venues such as PLoS Pathogens, Journal of Virology, mBio, bioRxiv (Cold Spring Harbor Laboratory), and The Journal of Experimental Medicine, highlighting a consistent focus on virology and immunological topics.

Best Publications

  • Cloning and mutagenesis of a herpesvirus genome as an infectious bacterial artificial chromosome

    Martin Messerle;Irena Crnkovic;Wolfgang Hammerschmidt;Heike Ziegler

  • Two genetically separable steps in the differentiation of thymic epithelium.

    Michael Nehls;Bruno Kyewski;Martin Messerle;Ralph Waldschütz

  • Cloning of the Human Cytomegalovirus (HCMV) Genome as an Infectious Bacterial Artificial Chromosome in Escherichia coli: a New Approach for Construction of HCMV Mutants

    Eva-Maria Borst;Gabriele Hahn;Ulrich H. Koszinowski;Martin Messerle

  • Human Cytomegalovirus Binding to DC-SIGN Is Required for Dendritic Cell Infection and Target Cell trans-Infection

    Franck Halary;Ali Amara;Hugues Lortat-Jacob;Martin Messerle

  • Cloning and sequencing of a highly productive, endotheliotropic virus strain derived from human cytomegalovirus TB40/E.

    Christian Sinzger;Gabriele Hahn;Margarete Digel;Ruth Katona

  • Cloning and Mutagenesis of the Murine Gammaherpesvirus 68 Genome as an Infectious Bacterial Artificial Chromosome

    Heiko Adler;Martin Messerle;Markus Wagner;Ulrich H. Koszinowski

  • Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells

    Quirin Hammer;Timo Rückert;Eva Maria Borst;Josefine Dunst

  • Systematic Excision of Vector Sequences from the BAC-Cloned Herpesvirus Genome during Virus Reconstitution

    Markus Wagner;Stipan Jonjić;Ulrich H. Koszinowski;Martin Messerle

  • Fast Screening Procedures for Random Transposon Libraries of Cloned Herpesvirus Genomes: Mutational Analysis of Human Cytomegalovirus Envelope Glycoprotein Genes

    Urs Hobom;Wolfram Brune;Martin Messerle;Gabriele Hahn

  • Lungs are a major organ site of cytomegalovirus latency and recurrence.

    M Balthesen;M Messerle;M J Reddehase

  • Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine.

    Scott G Hansen;Daniel E Zak;Guangwu Xu;Julia C Ford

  • In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity

    Stephan Halle;Kirsten Anja Keyser;Felix Rolf Stahl;Andreas Busche

  • Identification and expression of human cytomegalovirus transcription units coding for two distinct Fcγ receptor homologs

    Ramazan Atalay;Albert Zimmermann;Markus Wagner;Eva Borst

  • Late phase inhibition of murine cytomegalovirus replication by synergistic action of interferon-gamma and tumour necrosis factor.

    Pero Lučin;Stipan Jonjić;Martin Messerle;Bojan Polić

  • cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells

    Jennifer Paijo;Marius Döring;Julia Spanier;Elena Grabski

  • Molecular basis for cytolytic T-lymphocyte recognition of the murine cytomegalovirus immediate-early protein pp89

    M Del Val;H Volkmer;J B Rothbard;S Jonjić

  • Protection against lethal cytomegalovirus infection by a recombinant vaccine containing a single nonameric T-cell epitope.

    M Del Val;H J Schlicht;H Volkmer;M Messerle

  • NK cell activation through the NKG2D ligand MULT-1 is selectively prevented by the glycoprotein encoded by mouse cytomegalovirus gene m145

    Astrid Krmpotic;Milena Hasan;Andrea Loewendorf;Tanja Saulig

  • The Immunoevasive Function Encoded by the Mouse Cytomegalovirus Gene m152 Protects the Virus against T Cell Control in Vivo

    Astrid Krmpotic;Martin Messerle;Irena Crnkovic-Mertens;Bojan Polic

  • Rapid identification of essential and nonessential herpesvirus genes by direct transposon mutagenesis.

    Wolfram Brune;Carine Ménard;Urs Hobom;Stefan Odenbreit

Frequent Co-Authors

Ulrich H. Koszinowski
Ulrich H. Koszinowski Ludwig-Maximilians-Universität München
Stipan Jonjić
Stipan Jonjić University of Rijeka
Peter Ghazal
Peter Ghazal Cardiff University
Reinhold Förster
Reinhold Förster Hannover Medical School
Hartmut Hengel
Hartmut Hengel University of Freiburg
Ulrich Kalinke
Ulrich Kalinke Hannover Medical School
Michael Meyer-Hermann
Michael Meyer-Hermann Technische Universität Braunschweig
Thomas F. Schulz
Thomas F. Schulz Hannover Medical School
Günther M. Keil
Günther M. Keil Friedrich-Loeffler-Institut

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