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J. Timothy Greenamyre

J. Timothy Greenamyre

D-Index & Metrics

Medicine

D-Index
94
Citations
37687
World Ranking
10376
National Ranking
5339

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

J. Timothy Greenamyre is affiliated with the University of Pittsburgh in the United States. Their research primarily centers on medicine and neuroscience, with particular focus on neurology, cellular and molecular neuroscience, molecular biology, and physiology.

The main topics addressed in their work include Parkinson's disease mechanisms and treatments, nuclear receptors and signaling, neuroinflammation and neurodegeneration mechanisms, Alzheimer's disease research and treatments, RNA regulation and disease, neurological diseases and metabolism, and neurological disorders and treatments.

Frequent publication venues for Greenamyre's research comprise bioRxiv (Cold Spring Harbor Laboratory), npj Parkinson's Disease, Neurobiology of Disease, Redox Biology, and SSRN Electronic Journal.

  • Sandra L. Castro
  • Briana R. De Miranda
  • Roberto Di Maio
  • Emily M. Rocha
  • Matthew T. Keeney

The most recent scientific papers authored or coauthored by Greenamyre include:

  • "The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability", 2022, Cell
  • "The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a rat model of Parkinson's disease", 2021, Neurobiology of Disease
  • "Trichloroethylene, a ubiquitous environmental contaminant in the risk for Parkinson's disease", 2020, Environmental Science Processes & Impacts
  • "Transient exposure to rotenone causes degeneration and progressive parkinsonian motor deficits, neuroinflammation, and synucleinopathy", 2023, npj Parkinson's Disease
  • "Acquired dysregulation of dopamine homeostasis reproduces features of Parkinson's disease", 2020, npj Parkinson's Disease

Greenamyre has been recognized as a Member of the Association of American Physicians. Their work engages deeply with the pathophysiological mechanisms underpinning Parkinson's disease and related neurodegenerative disorders.

Best Publications

  • Mechanism of toxicity in rotenone models of Parkinson's disease.

    Todd B. Sherer;Ranjita Betarbet;Claudia M. Testa;Byoung Boo Seo

  • Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines

    Alexander V. Panov;Claire-Anne Gutekunst;Blair R. Leavitt;Michael R. Hayden

  • Subcutaneous Rotenone Exposure Causes Highly Selective Dopaminergic Degeneration and α-Synuclein Aggregation

    Todd B Sherer;Jin Ho Kim;Jin Ho Kim;Ranjita Betarbet;J Timothy Greenamyre

  • A highly reproducible rotenone model of Parkinson's disease

    Jason R. Cannon;Victor M. Tapias;Hye Mee Na;Anthony S. Honick

  • Animal models of Parkinson's disease

    Ranjita Betarbet;Todd B. Sherer;J. Timothy Greenamyre

  • Alternative excitotoxic hypotheses.

    R. L. Albin;J. T. Greenamyre

  • An In Vitro Model of Parkinson's Disease: Linking Mitochondrial Impairment to Altered α-Synuclein Metabolism and Oxidative Damage

    Todd B. Sherer;Ranjita Betarbet;Amy K. Stout;Serena Lund

  • Excitatory amino acids and Alzheimer's disease.

    J.Timothy Greenamyre;Anne B. Young

  • α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

    Roberto Di Maio;Paul J. Barrett;Eric K. Hoffman;Caitlyn W. Barrett

  • LRRK2 activation in idiopathic Parkinson’s disease

    Roberto Di Maio;Eric K. Hoffman;Emily M. Rocha;Matthew T. Keeney

  • Parkinson's--Divergent Causes, Convergent Mechanisms

    J. Timothy Greenamyre;Teresa G. Hastings

  • Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization

    Akira Sawa;Gordon W. Wiegand;Jillian Cooper;Russell L. Margolis

  • N-Terminal Mutant Huntingtin Associates with Mitochondria and Impairs Mitochondrial Trafficking

    Adam L. Orr;Shihua Li;Chuan-En Wang;He Li

  • Intersecting pathways to neurodegeneration in Parkinson's disease: Effects of the pesticide rotenone on DJ-1, α-synuclein, and the ubiquitin–proteasome system

    Ranjita Betarbet;Rosa M. Canet-Aviles;Todd B. Sherer;Pier G. Mastroberardino

  • The Role of Environmental Exposures in Neurodegeneration and Neurodegenerative Diseases

    Jason R. Cannon;J. Timothy Greenamyre

  • Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives.

    Anthony H V Schapira;C Warren Olanow;J Timothy Greenamyre;Erwan Bezard;Erwan Bezard

  • Complex I and Parkinson's disease.

    J. Timothy Greenamyre;Todd B. Sherer;Ranjita Betarbet;Alexander V. Panov

  • Glutamate dysfunction in Alzheimer's disease: an hypothesis

    William F. Maragos;J.Timothy Greenamyre;John B. Penney;Anne B. Young

  • Alterations in L-glutamate binding in Alzheimer's and Huntington's diseases.

    JT Greenamyre;JB Penney;AB Young;CJ D'Amato

  • Selective microglial activation in the rat rotenone model of Parkinson's disease.

    Todd B Sherer;Ranjita Betarbet;Jin Ho Kim;J Timothy Greenamyre

Frequent Co-Authors

Anne B. Young
Anne B. Young Harvard University
Teresa G. Hastings
Teresa G. Hastings University of Pittsburgh
Fabio Blandini
Fabio Blandini University of Pavia
John B. Penney
John B. Penney University of Michigan–Ann Arbor
Gary W. Miller
Gary W. Miller Columbia University
Takao Yagi
Takao Yagi Scripps Research Institute
Ira Shoulson
Ira Shoulson Georgetown University
Karl Kieburtz
Karl Kieburtz University of Rochester Medical Center
Erwan Bezard
Erwan Bezard University of Bordeaux
Michael R. Hayden
Michael R. Hayden University of British Columbia

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