Keiichi Higuchi

Overview

Best Publications

• Fluorometric determination of amyloid fibrils in vitro using the fluorescent dye, thioflavin T1.

  Hironobu Naiki;Keiichi Higuchi;Masanori Hosokawa;Toshio Takeda

  1431
  Citations

• Senescence-accelerated-mouse (SAM) : a novel murine model of accelerated senescence

  Toshio Takeda;Masanori Hosokawa;Keiichi Higuchi

  512
  Citations

• Senescence-accelerated mouse (SAM): a novel murine model of senescence.

  Toshio Takeda;Masanori Hosokawa;Keiichi Higuchi

  427
  Citations

• Age-related changes in bone mass in the senescence-accelerated mouse (SAM). SAM-R/3 and SAM-P/6 as new murine models for senile osteoporosis.

  M Matsushita;T Tsuboyama;R Kasai;H Okumura

  322
  Citations

• Grading score system: a method for evaluation of the degree of senescence in senescence accelerated mouse (SAM).

  Hosokawa M;Kasai R;Higuchi K;Takeshita S

  278
  Citations

• Pathobiology of the senescence-accelerated mouse (SAM)

  Toshio Takeda;Takatoshi Matsushita;Mafumi Kurozumi;Kiminobu Takemura

  254
  Citations

• Human liver apolipoprotein B-100 cDNA: complete nucleic acid and derived amino acid sequence

  S W Law;S M Grant;K Higuchi;A Hospattankar

  248
  Citations

• Kinetic analysis of amyloid fibril polymerization in vitro.

  H Naiki;K Higuchi;K Nakakuki;T Takeda

  245
  Citations

• Cardiac amyloid in patients with familial amyloid polyneuropathy consists of abundant wild-type transthyretin.

  Masahide Yazaki;Takahiko Tokuda;Akihiro Nakamura;Takeo Higashikata

  225
  Citations

• Exercise effects on methylation of ASC gene.

  K. Nakajima;M. Takeoka;M. Mori;S. Hashimoto

  204
  Citations

• SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda's legacy and future directions.

  Ichiro Akiguchi;Ichiro Akiguchi;Mercè Pallàs;Herbert Budka;Haruhiko Akiyama

  173
  Citations

• Fecal transmission of AA amyloidosis in the cheetah contributes to high incidence of disease.

  Beiru Zhang;Yumi Une;Xiaoying Fu;Jingmin Yan

  164
  Citations

• Systemic senile amyloid in senescence-accelerated mice. A unique fibril protein demonstrated in tissues from various organs by the unlabeled immunoperoxidase method.

  Higuchi K;Matsumura A;Honma A;Takeshita S

  150
  Citations

• Purification and characterization of a senile amyloid-related antigenic substance (apoSASSAM) from mouse serum. apoSASSAM is an apoA-II apolipoprotein of mouse high density lipoproteins.

  K Higuchi;T Yonezu;K Kogishi;A Matsumura

  133
  Citations

• Secreted frizzled-related protein 4 is a negative regulator of peak BMD in SAMP6 mice

  Rika Nakanishi;Motoyuki Shimizu;Masayuki Mori;Haruhiko Akiyama

  131
  Citations

• Polymorphism of apolipoprotein A-II (apoA-II) among inbred strains of mice. Relationship between the molecular type of apoA-II and mouse senile amyloidosis.

  K Higuchi;K Kitagawa;H Naiki;K Hanada

  130
  Citations

• Lanosterol synthase mutations cause cholesterol deficiency–associated cataracts in the Shumiya cataract rat

  Masayuki Mori;Guixin Li;Ikuro Abe;Jun Nakayama

  129
  Citations

• Identification of peak bone mass QTL in a spontaneously osteoporotic mouse strain.

  Motoyuki Shimizu;Keiichi Higuchi;Beth Bennett;Chen Xia

  127
  Citations

• Ubiquinol-10 Supplementation Activates Mitochondria Functions to Decelerate Senescence in Senescence-Accelerated Mice

  Geng Tian;Jinko Sawashita;Hiroshi Kubo;Shin-ya Nishio

  127
  Citations

• Coenzyme Q10 Improves Lipid Metabolism and Ameliorates Obesity by Regulating CaMKII-Mediated PDE4 Inhibition.

  Zhe Xu;Jia Huo;Xin Ding;Mu Yang

  113
  Citations