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Hironobu Naiki

Hironobu Naiki

D-Index & Metrics

Biology and Biochemistry

D-Index
76
Citations
20018
World Ranking
5065
National Ranking
331

Overview

Hironobu Naiki is affiliated with the University of Fukui in Japan. Their research focuses primarily on medical and biochemical fields, with significant contributions to the study and diagnosis of amyloidosis. Their work frequently appears in venues such as Pathology International, Amyloid, and Scientific Reports, reflecting a focused expertise in pathology and related biomedical sciences.

Naiki's publication record features key papers that address the pathology and clinical diagnosis of amyloidosis and related conditions. Notable papers include:

  • Human amyloidosis, still intractable but becoming curable: The essential role of pathological diagnosis in the selection of type-specific therapeutics (2020, Pathology International)
  • Steep increase in the number of transthyretin-positive cardiac biopsy cases in Japan: evidence obtained by the nation-wide pathology consultation for the typing diagnosis of amyloidosis (2023, Amyloid)

The scope of Naiki's research includes molecular biology and genetics, as well as clinical nephrology and rheumatology, indicating a multidisciplinary approach to understanding disease mechanisms and treatment outcomes. The main fields of study are:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

More specialized subfields cover:

  • Molecular Biology
  • Nephrology
  • Rheumatology
  • Genetics
  • Physiology

The major research topics explored involve amyloidosis diagnosis, treatment, and outcomes, with additional work on trace elements in health, Alzheimer's disease research, IgG4-related and inflammatory diseases, parathyroid disorders, drug transport, and dermatological and skeletal disorders. Main topics of Naiki's work include:

  • Amyloidosis: Diagnosis, Treatment, Outcomes
  • Trace Elements in Health
  • Alzheimer's disease research and treatments
  • IgG4-Related and Inflammatory Diseases
  • Parathyroid Disorders and Treatments
  • Drug Transport and Resistance Mechanisms
  • Dermatological and Skeletal Disorders

Collaboration is a notable aspect of Naiki's research activity. Frequent coauthors include:

  • Yoshiki Sekijima
  • Mitsuharu Ueda
  • Masayuki Iwano
  • Aina Yamaguchi
  • Naoki Takahashi

Common publication venues for Naiki's contributions are:

  • Pathology International
  • Amyloid
  • Scientific Reports
  • Neurobiology of Disease
  • Clinical Journal of Gastroenterology

The research output demonstrates a sustained focus on amyloidosis and related systemic diseases, combining pathological analysis with clinical and molecular approaches. Naiki's work features a combination of original research papers and collaborative studies that contribute to the understanding of complex diseases within the medical and biochemical realms.

Best Publications

  • Fluorometric determination of amyloid fibrils in vitro using the fluorescent dye, thioflavin T1.

    Hironobu Naiki;Keiichi Higuchi;Masanori Hosokawa;Toshio Takeda

  • Curcumin has potent anti-amyloidogenic effects for Alzheimer's β-amyloid fibrils in vitro

    Kenjiro Ono;Kazuhiro Hasegawa;Hironobu Naiki;Masahito Yamada

  • Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease

    Kenjiro Ono;Yuji Yoshiike;Akihiko Takashima;Kazuhiro Hasegawa

  • Direct observation of amyloid fibril growth monitored by thioflavin T fluorescence.

    Tadato Ban;Daizo Hamada;Kazuhiro Hasegawa;Hironobu Naiki

  • ThT 101: a primer on the use of thioflavin T to investigate amyloid formation

    Kirsten Gade Malmos;Luis M. Blancas-Mejia;Benedikt Weber;Johannes Buchner

  • A toxic monomeric conformer of the polyglutamine protein.

    Yoshitaka Nagai;Takashi Inui;Takashi Inui;Takashi Inui;H Akiko Popiel;Nobuhiro Fujikake

  • Mapping the core of the beta(2)-microglobulin amyloid fibril by H/D exchange.

    Masaru Hoshino;Hidenori Katou;Yoshihisa Hagihara;Yoshihisa Hagihara;Kazuhiro Hasegawa

  • Distinguishing crystal-like amyloid fibrils and glass-like amorphous aggregates from their kinetics of formation

    Yuichi Yoshimura;Yuxi Lin;Hisashi Yagi;Young-Ho Lee

  • First-order kinetic model of Alzheimer's beta-amyloid fibril extension in vitro.

    H Naiki;K Nakakuki

  • Iron (III) induces aggregation of hyperphosphorylated τ and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease

    Akira Yamamoto;Akira Yamamoto;Ryong Woon Shin;Kazuhiro Hasegawa;Hironobu Naiki

  • Iron (III) induces aggregation of hyperphosphorylated τ and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease: τ Aggregation by iron (III)

    Akira Yamamoto;Ryong-Woon Shin;Kazuhiro Hasegawa;Hironobu Naiki

  • Anti-amyloidogenic activity of tannic acid and its activity to destabilize Alzheimer's β-amyloid fibrils in vitro

    Kenjiro Ono;Kazuhiro Hasegawa;Hironobu Naiki;Masahito Yamada

  • A Seed for Alzheimer Amyloid in the Brain

    Hideki Hayashi;Nobuyuki Kimura;Haruyasu Yamaguchi;Kazuhiro Hasegawa

  • Establishment of a kinetic model of dialysis-related amyloid fibril extension in vitro

    Hironobu Naiki;Norikazu Hashimoto;Satoru Suzuki;Hideki Kimura

  • Direct observation of Aβ amyloid fibril growth and inhibition

    Tadato Ban;Masaru Hoshino;Satoshi Takahashi;Daizo Hamada

  • 3D structure of amyloid protofilaments of beta2-microglobulin fragment probed by solid-state NMR

    Kentaro Iwata;Toshimichi Fujiwara;Yoh Matsuki;Hideo Akutsu

  • Interaction between Aβ (1-42) and Aβ (1-40) in Alzheimer's β-amyloid fibril formation in vitro

    Kazuhiro Hasegawa;Itaru Yamaguchi;Saburou Omata;Fumitake Gejyo

  • Kinetic analysis of amyloid fibril polymerization in vitro.

    H Naiki;K Higuchi;K Nakakuki;T Takeda

  • Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2

    Josephine C. Ferreon;Chul Won Lee;Munehito Arai;Maria A. Martinez-Yamout

  • Presence of ras oncogene mutations and human papillomavirus DNA in human prostate carcinomas.

    Anwar K;Nakakuki K;Shiraishi T;Naiki H

Frequent Co-Authors

Yuji Goto
Yuji Goto Osaka University
Masahito Yamada
Masahito Yamada Kanazawa University
Keiichi Higuchi
Keiichi Higuchi Shinshu University
Fumitake Gejyo
Fumitake Gejyo Niigata University
Toshio Takeda
Toshio Takeda Kyoto University
Masanori Hosokawa
Masanori Hosokawa Kyoto University
Tomoji Kawai
Tomoji Kawai Osaka University
Satoshi Takahashi
Satoshi Takahashi Tohoku University
Katsumi Matsuzaki
Katsumi Matsuzaki Kyoto University
Akihiko Takashima
Akihiko Takashima Gakushuin University

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