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D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
14211
World Ranking
13051
National Ranking
1018

Overview

Vittorio Bellotti is affiliated with University College London in the United Kingdom. Their research spans biochemistry, genetics, molecular biology, and medicine, with a strong focus on molecular biology and physiology as key subfields. Surgery and oncology also form part of their research scope, contributing to a multidisciplinary approach within biomedical sciences.

Their scientific work covers multiple topics, prominently including amyloidosis diagnosis, treatment, and outcomes, Alzheimer's disease research and treatments, and protein kinase regulation and GTPase signaling. Other notable areas include protein structure and dynamics, hip disorders and treatments, peptidase inhibition and analysis, and orthopaedic implants and arthroplasty.

Bellotti has contributed to several recent papers published between 2020 and 2022. These publications include:

  • A Narrative Review of the Role of Transthyretin in Health and Disease, 2020, Neurology and Therapy
  • Diagnostic amyloid proteomics: experience of the UK National Amyloidosis Centre, 2020, Clinical Chemistry and Laboratory Medicine (CCLM)
  • L444P Gba1 mutation increases formation and spread of α-synuclein deposits in mice injected with mouse α-synuclein pre-formed fibrils, 2020, PLoS ONE
  • Comparative study of the stabilities of synthetic in vitro and natural ex vivo transthyretin amyloid fibrils, 2020, Journal of Biological Chemistry
  • Amyloid Formation by Globular Proteins: The Need to Narrow the Gap Between in Vitro and in Vivo Mechanisms, 2022, Frontiers in Molecular Biosciences

Their frequent co-authors include Guglielmo Verona, Diana Canetti, Sofia Giorgetti, P. Patrizia Mangione, and Julian D. Gillmore, indicating ongoing collaborative relationships in their research endeavors.

Bellotti's publications appear regularly in several scientific journals, with notable venues including the Journal of Biological Chemistry, The Journal of Arthroplasty, Amyloid, Revista Española de Cirugía Ortopédica y Traumatología, and Neurology and Therapy. Their work in the Journal of Biological Chemistry is especially prominent, with three publications within this journal.

Best Publications

  • Molecular mechanisms of amyloidosis.

    Giampaolo Merlini;Vittorio Bellotti

  • Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis

    David R. Booth;Margaret Sunde;Vittorio Bellotti;Vittorio Bellotti;Carol V. Robinson

  • Targeting C-reactive protein for the treatment of cardiovascular disease

    Mark B Pepys;Gideon M Hirschfield;Glenys A Tennent;J Ruth Gallimore

  • Antibodies to human serum amyloid P component eliminate visceral amyloid deposits

    Karl Bodin;Stephan Ellmerich;Melvyn C. Kahan;Glenys A. Tennent

  • Rapid Proton-Detected NMR Assignment for Proteins with Fast Magic Angle Spinning

    Emeline Barbet-Massin;Andrew J. Pell;Joren S. Retel;Loren B. Andreas;Loren B. Andreas

  • Removal of the N-terminal hexapeptide from human beta2-microglobulin facilitates protein aggregation and fibril formation.

    G. Esposito;R. Michelutti;G. Verdone;P. Viglino

  • Review: immunoglobulin light chain amyloidosis--the archetype of structural and pathogenic variability.

    Vittorio Bellotti;Palma Mangione;Giampaolo Merlini

  • Hereditary systemic amyloidosis due to Asp76Asn variant β2-microglobulin

    Sophie Valleix;Julian D Gillmore;Franck Bridoux;Palma P Mangione;Palma P Mangione

  • The solution structure of human β2-microglobulin reveals the prodromes of its amyloid transition

    Giuliana Verdone;Alessandra Corazza;Paolo Viglino;Fabio Pettirossi

  • Structure, function and amyloidogenic propensity of apolipoprotein A-I

    Laura Obici;Guido Franceschini;Laura Calabresi;Sofia Giorgetti

  • A partially structured species of beta 2-microglobulin is significantly populated under physiological conditions and involved in fibrillogenesis.

    Fabrizio Chiti;Ersilia De Lorenzi;Silvia Grossi;Palma Mangione

  • The New Apolipoprotein A-I Variant Leu174 → Ser Causes Hereditary Cardiac Amyloidosis, and the Amyloid Fibrils Are Constituted by the 93-Residue N-Terminal Polypeptide

    Laura Obici;Vittorio Bellotti;Palma Mangione;Monica Stoppini

  • Detection of two partially structured species in the folding process of the amyloidogenic protein beta 2-microglobulin.

    Fabrizio Chiti;Palma Mangione;Alessia Andreola;Sofia Giorgetti

  • Collagen Plays an Active Role in the Aggregation of β2-Microglobulin under Physiopathological Conditions of Dialysis-related Amyloidosis

    Annalisa Relini;Claudio Canale;Silvia De Stefano;Ranieri Rolandi

  • Biological activity and pathological implications of misfolded proteins.

    Vittorio Bellotti;Palma Mangione;Monica Stoppini

  • Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology.

    María Izco;Javier Blesa;Martin Schleef;Marco Schmeer

  • Amyloidogenic and Associated Proteins in Systemic Amyloidosis Proteome of Adipose Tissue

    Francesca Lavatelli;David H. Perlman;Brian Spencer;Tatiana Prokaeva

  • A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis

    Julien Marcoux;Julien Marcoux;P Patrizia Mangione;P Patrizia Mangione;Riccardo Porcari;Matteo T Degiacomi

  • Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic β2-microglobulin variant

    Katarzyna Domanska;Saskia Vanderhaegen;Vasundara Srinivasan;Els Pardon

  • Amyloidogenesis in its biological environment: challenging a fundamental issue in protein misfolding diseases.

    Vittorio Bellotti;Fabrizio Chiti

Frequent Co-Authors

Giampaolo Merlini
Giampaolo Merlini University of Pavia
Gennaro Esposito
Gennaro Esposito New York University Abu Dhabi
Martino Bolognesi
Martino Bolognesi University of Milan
Mark B. Pepys
Mark B. Pepys University College London
Julian D. Gillmore
Julian D. Gillmore University College London
Piero Pucci
Piero Pucci University of Naples Federico II
Maria Chiara Monti
Maria Chiara Monti University of Salerno
Carol V. Robinson
Carol V. Robinson University of Oxford
Massimo Stefani
Massimo Stefani University of Florence
Fabrizio Chiti
Fabrizio Chiti University of Florence

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