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Masanori Hosokawa

Masanori Hosokawa

D-Index & Metrics

Biology and Biochemistry

D-Index
50
Citations
10879
World Ranking
17530
National Ranking
1267

Overview

Masanori Hosokawa is affiliated with Kyoto University in Japan and specializes in research intersecting Medicine and Computer Science. Their work predominantly focuses on Pharmacology, Computational Theory and Mathematics, and Molecular Biology, with additional contributions spanning Biomaterials and Cardiology and Cardiovascular Medicine.

Their research covers several main topics, including:

  • Computational Drug Discovery Methods
  • Cholinesterase and Neurodegenerative Diseases
  • Pharmacogenetics and Drug Metabolism
  • Muscle Physiology and Disorders
  • Silk-based biomaterials and applications
  • Cardiomyopathy and Myosin Studies
  • Zebrafish Biomedical Research Applications

Recent publications by Masanori Hosokawa and their collaborators demonstrate a focus on biochemical pharmacology and disease biomarkers. Key papers include:

  • "Effects of steric hindrance and electron density of ester prodrugs on controlling the metabolic activation by human carboxylesterase" (2021) published in Drug Metabolism and Pharmacokinetics
  • "Titin fragment is a sensitive biomarker in Duchenne muscular dystrophy model mice carrying full-length human dystrophin gene on human artificial chromosome" (2025) published in Scientific Reports
  • "Design, synthesis and biological evaluation of water-soluble phenytoin prodrugs considering the substrate recognition ability of human carboxylesterase 1" (2020) published in European Journal of Pharmaceutical Sciences
  • "The Zebrafish Cerebellar Neural Circuits Are Involved in Orienting Behavior" (2024) published in eNeuro
  • "Synthesis and evaluation of indomethacin prodrugs with a diester structure that are metabolically activated by human carboxylesterases" (2023) published in Xenobiotica

Frequent coauthors in Hosokawa's research include Masato Takahashi, Masami Haba, Daisuke Takani, Kohei Takahashi, and Ibuki Hirota, indicating collaboration across multiple studies involving drug metabolism and pharmacokinetics.

Publication venues commonly featuring Hosokawa's work are:

  • Drug Metabolism and Pharmacokinetics
  • Scientific Reports
  • eNeuro
  • European Journal of Pharmaceutical Sciences
  • Xenobiotica

The interdisciplinary nature of Hosokawa's work bridges computational methods and biomedical applications. This includes computational approaches to drug discovery alongside studies addressing enzyme activity related to human carboxylesterases and their role in drug metabolism and activation. Additionally, research extends to muscle physiology and neuromuscular disorders, including investigations into biomarkers for muscular dystrophy and neural circuits in zebrafish models, reflecting an integration of molecular biology and experimental neuroscience.

Best Publications

  • Fluorometric determination of amyloid fibrils in vitro using the fluorescent dye, thioflavin T1.

    Hironobu Naiki;Keiichi Higuchi;Masanori Hosokawa;Toshio Takeda

  • Senescence-accelerated-mouse (SAM) : a novel murine model of accelerated senescence

    Toshio Takeda;Masanori Hosokawa;Keiichi Higuchi

  • Senescence-accelerated mouse (SAM): a novel murine model of senescence.

    Toshio Takeda;Masanori Hosokawa;Keiichi Higuchi

  • Embryonic lethality of molecular chaperone hsp47 knockout mice is associated with defects in collagen biosynthesis.

    Naoko Nagai;Masanori Hosokawa;Shigeyoshi Itohara;Eijiro Adachi

  • Grading score system: a method for evaluation of the degree of senescence in senescence accelerated mouse (SAM).

    Hosokawa M;Kasai R;Higuchi K;Takeshita S

  • Pathobiology of the senescence-accelerated mouse (SAM)

    Toshio Takeda;Takatoshi Matsushita;Mafumi Kurozumi;Kiminobu Takemura

  • SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda's legacy and future directions.

    Ichiro Akiguchi;Ichiro Akiguchi;Mercè Pallàs;Herbert Budka;Haruhiko Akiyama

  • Spontaneous Spongy Degeneration of the Brain Stem in SAM-P/8 Mice, a Newly Developed Memory-Deficient Strain

    Hideo Yagi;Mika Irino;Takatoshi Matsushita;Seika Katoh

  • A higher oxidative status accelerates senescence and aggravates age-dependent disorders in SAMP strains of mice

    Masanori Hosokawa

  • Systemic senile amyloid in senescence-accelerated mice. A unique fibril protein demonstrated in tissues from various organs by the unlabeled immunoperoxidase method.

    Higuchi K;Matsumura A;Honma A;Takeshita S

  • Purification and characterization of a senile amyloid-related antigenic substance (apoSASSAM) from mouse serum. apoSASSAM is an apoA-II apolipoprotein of mouse high density lipoproteins.

    K Higuchi;T Yonezu;K Kogishi;A Matsumura

  • Secreted frizzled-related protein 4 is a negative regulator of peak BMD in SAMP6 mice

    Rika Nakanishi;Motoyuki Shimizu;Masayuki Mori;Haruhiko Akiyama

  • Polymorphism of apolipoprotein A-II (apoA-II) among inbred strains of mice. Relationship between the molecular type of apoA-II and mouse senile amyloidosis.

    K Higuchi;K Kitagawa;H Naiki;K Hanada

  • Identification of peak bone mass QTL in a spontaneously osteoporotic mouse strain.

    Motoyuki Shimizu;Keiichi Higuchi;Beth Bennett;Chen Xia

  • Dietary α-linolenate/linoleate balance influences learning and memory in the senescence-accelerated mouse (SAM)

    Makiko Umezawa;Akira Ohta;Hiromasa Tojo;Hideo Yagi

  • Neuropathological studies on strains of senescence-accelerated mice (SAM) with age-related deficits in learning and memory.

    Toshio Kawamata;Ichiro Akiguchi;Hideo Yagi;Mika Irino

  • Accelerated accumulation of somatic mutations in the senescence-accelerated mouse

    Youichi Odagiri;Hiroyuki Uchida;Masanori Hosokawa;Kazuo Takemoto

  • Risk of Fall for Individuals With Intellectual Disability

    Yoichi Chiba;Atsuyoshi Shimada;Futoshi Yoshida;Hiromi Keino

  • Age-related changes in the temporomandibular joint of the senescence accelerated mouse. SAM-P/3 as a new murine model of degenerative joint disease.

    W H Chen;M Hosokawa;T Tsuboyama;T Ono

  • Fluorometric Examination of Tissue Amyloid Fibrils in Murine Senile Amyloidosis: Use of the Fluorescent Indicator, Thioflavine T

    Hironobu Naiki;Keiichi Higuchi;Kaori Kitagawa;Atsuyoshi Shimada

Frequent Co-Authors

Keiichi Higuchi
Keiichi Higuchi Shinshu University
Toshio Takeda
Toshio Takeda Kyoto University
Hironobu Naiki
Hironobu Naiki University of Fukui
Takashi Nakamura
Takashi Nakamura Kyoto University
Jun Kimura
Jun Kimura University of Iowa
Rudolf K. Zahn
Rudolf K. Zahn Johannes Gutenberg University of Mainz
Tetsuya Hayashi
Tetsuya Hayashi Kyushu University
Yasuyuki Nomura
Yasuyuki Nomura Kurume University
Haruhiko Akiyama
Haruhiko Akiyama Gifu University
Kazuhiro Nagata
Kazuhiro Nagata Kyoto Sangyo University

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