Toshio Takeda

Overview

Best Publications

• Fluorometric determination of amyloid fibrils in vitro using the fluorescent dye, thioflavin T1.

  Hironobu Naiki;Keiichi Higuchi;Masanori Hosokawa;Toshio Takeda

  1431
  Citations

• Age-related changes in learning and memory in the senescence-accelerated mouse (SAM)

  Masaomi Miyamoto;Yoshihiro Kiyota;Naoki Yamazaki;Akinobu Nagaoka

  532
  Citations

• Senescence-accelerated-mouse (SAM) : a novel murine model of accelerated senescence

  Toshio Takeda;Masanori Hosokawa;Keiichi Higuchi

  512
  Citations

• Induction of inflammatory arthropathy resembling rheumatoid arthritis in mice transgenic for HTLV-I.

  Yoichiro Iwakura;Mariko Tosu;Emi Yoshida;Masafumi Takiguchi

  499
  Citations

• Senescence-accelerated mouse (SAM): a novel murine model of senescence.

  Toshio Takeda;Masanori Hosokawa;Keiichi Higuchi

  427
  Citations

• Senescence-accelerated mouse (SAM): a biogerontological resource in aging research.

  Toshio Takeda

  408
  Citations

• Age-related deterioration of ability of acquisition in memory and learning in senescence accelerated mouse: SAM-P/8 as an animal model of disturbances in recent memory

  Hideo Yagi;Seika Katoh;Ichiro Akiguchi;Toshio Takeda

  338
  Citations

• Grading score system: a method for evaluation of the degree of senescence in senescence accelerated mouse (SAM).

  Hosokawa M;Kasai R;Higuchi K;Takeshita S

  278
  Citations

• Pathobiology of the senescence-accelerated mouse (SAM)

  Toshio Takeda;Takatoshi Matsushita;Mafumi Kurozumi;Kiminobu Takemura

  254
  Citations

• Spontaneous Spongy Degeneration of the Brain Stem in SAM-P/8 Mice, a Newly Developed Memory-Deficient Strain

  Hideo Yagi;Mika Irino;Takatoshi Matsushita;Seika Katoh

  161
  Citations

• Systemic senile amyloid in senescence-accelerated mice. A unique fibril protein demonstrated in tissues from various organs by the unlabeled immunoperoxidase method.

  Higuchi K;Matsumura A;Honma A;Takeshita S

  150
  Citations

• Inbred SAM-P/10 as a mouse model of spontaneous, inherited brain atrophy.

  Atsuyoshi Shimada;Akira Ohta;Ichiro Akiguchi;Toshio Takeda

  141
  Citations

• Purification and characterization of a senile amyloid-related antigenic substance (apoSASSAM) from mouse serum. apoSASSAM is an apoA-II apolipoprotein of mouse high density lipoproteins.

  K Higuchi;T Yonezu;K Kogishi;A Matsumura

  133
  Citations

• Beta/A4 proteinlike immunoreactive granular structures in the brain of senescence-accelerated mouse.

  M. Takemura;S. Nakamura;I. Akiguchi;M. Ueno

  133
  Citations

• Polymorphism of apolipoprotein A-II (apoA-II) among inbred strains of mice. Relationship between the molecular type of apoA-II and mouse senile amyloidosis.

  K Higuchi;K Kitagawa;H Naiki;K Hanada

  130
  Citations

• Experimental Studies on Connective Tissue of the Capsular Ligament: Influences of Aging and Sex Hormones

  Hiromichi Hama;Takao Yamamuro;Toshio Takeda

  130
  Citations

• Ubiquinol-10 Supplementation Activates Mitochondria Functions to Decelerate Senescence in Senescence-Accelerated Mice

  Geng Tian;Jinko Sawashita;Hiroshi Kubo;Shin-ya Nishio

  127
  Citations

• Periodic acid-Schiff (PAS)-positive, granular structures increase in the brain of senescence accelerated mouse (SAM).

  H. Akiyama;M. Kameyama;I. Akiguchi;H. Sugiyama

  117
  Citations

• Senescence-Accelerated Mouse (SAM). A novel murine model of aging

  T. Takeda

  114
  Citations

• Methods in laboratory investigation : fluroremetric examination of tissue amyloid fibrils in murine senile amyloidosis : use of the fluorescent indicator, thioflavine T

  H. Naiki;K. Higuchi;K. Martsushima;A. Shimada

  111
  Citations