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Chemistry

D-Index
48
Citations
10941
World Ranking
15081
National Ranking
3840

Research.com Recognitions

  • 1995 - Fellow of Alfred P. Sloan Foundation

Overview

Eric J. Toone is affiliated with Duke University in the United States and focuses their research primarily in the field of Biochemistry, Genetics and Molecular Biology. Their work spans various subfields including Molecular Medicine, Genetics, Microbiology, Immunology, and Endocrinology.

Their research addresses multiple core topics, notably:

  • Antibiotic Resistance in Bacteria
  • Antimicrobial Peptides and Activities
  • Immune Response and Inflammation
  • Bacterial Genetics and Biotechnology
  • Vibrio bacteria research studies
  • Monoclonal and Polyclonal Antibodies Research
  • Yersinia bacterium, plague, ectoparasites research

Among recent publications, Eric J. Toone has contributed to the following papers:

  • "Preclinical safety and efficacy characterization of an LpxC inhibitor against Gram-negative pathogens," 2023, Science Translational Medicine
  • "Degradation of Components of the Lpt Transenvelope Machinery Reveals LPS-Dependent Lpt Complex Stability in Escherichia coli," 2021, Frontiers in Molecular Biosciences
  • "Species-Specific and Inhibitor-Dependent Conformations of LpxC: Implications for Antibiotic Design," 2020, UNC Libraries
  • "Assessing the threat of Yersinia pestis harboring a multi-resistant IncC plasmid and the efficacy of an antibiotic targeting LpxC," 2025, Antimicrobial Agents and Chemotherapy

Frequent co-authors in their work include:

  • Pei Zhou (4 collaborations)
  • David M. Gooden (2 collaborations)
  • Nadine Lemaître (2 collaborations)
  • Robert A. Nicholas (2 collaborations)
  • Florent Sebbane (2 collaborations)

Their research has been published in various scientific venues such as:

  • Science Translational Medicine
  • Frontiers in Molecular Biosciences
  • UNC Libraries
  • Antimicrobial Agents and Chemotherapy

Eric J. Toone was awarded the title of Fellow of the Alfred P. Sloan Foundation in 1995.

Best Publications

  • The cluster glycoside effect.

    Joseph J Lundquist;Eric J Toone

  • (S)NO signals: translocation, regulation, and a consensus motif.

    Jonathan S. Stamler;Eric J. Toone;Stuart A. Lipton;Nikolaus J. Sucher

  • Enzyme-catalyzed synthesis of carbohydrates

    Eric J. Toone;Ethan S. Simon;Mark D. Bednarski;George M. Whitesides

  • Structure and energetics of protein-carbohydrate complexes

    Eric J. Toone

  • A Direct Measure of the Contribution of Solvent Reorganization to the Enthalpy of Binding

    Mary C. Chervenak;Eric J. Toone

  • On the Meaning of Affinity: Cluster Glycoside Effects and Concanavalin A

    Sarah M. Dimick;Steven C. Powell;Stephen A. McMahon;Davina N. Moothoo

  • Enzymes in organic synthesis. 47. Active-site model for interpreting and predicting the specificity of pig liver esterase

    Eric J. Toone;Michael J. Werth;J. Bryan Jones

  • Polymers for delivering nitric oxide in vivo

    Jonathan S. Stamler;Eric J. Toone;Richard S. Stack

  • In situ growth of a stoichiometric PEG-like conjugate at a protein's N-terminus with significantly improved pharmacokinetics.

    Weiping Gao;Wenge Liu;J. Andrew Mackay;Michael R. Zalutsky

  • A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells

    Ann M. Winter-Vann;Rudi A. Baron;Waihay Wong;June dela Cruz

  • The decomposition of thionitrites

    Jonathan S Stamler;Eric J Toone

  • Calorimetric analysis of the binding of lectins with overlapping carbohydrate-binding ligand specificities

    Mary C. Chervenak;Eric J. Toone

  • Interaction of the Shiga-like toxin type 1 B-subunit with its carbohydrate receptor.

    P. M. St. Hilaire;M. K. Boyd;E. J. Toone

  • Exploring the basis of peptide-carbohydrate crossreactivity: evidence for discrimination by peptides between closely related anti-carbohydrate antibodies.

    Shannon L. Harris;Lisa Craig;Jarnail S. Mehroke;Michael Rashed

  • S-N dissociation energies of S-nitrosothiols: on the origins of nitrosothiol decomposition rates.

    Michael D. Bartberger;Joseph D. Mannion;Steven C. Powell;Jonathan S. Stamler

  • Regioselective reduction of 4,6-O-benzylidenes using triethylsilane and BF3·Et2O

    Sheryl D Debenham;Eric J Toone

  • Specificity of C-glycoside complexation by mannose/glucose specific lectins.

    Ross V. Weatherman;Kathleen H. Mortell;Mary Chervenak;Laura L. Kiessling

  • Additivity and the physical basis of multivalency effects: a thermodynamic investigation of the calcium EDTA interaction.

    Trine Christensen;David M. Gooden;Joyce E. Kung;Eric J. Toone

  • A comparison of biological and calorimetric analyses of multivalent glycodendrimer ligands for concanavalin A

    Jayme B. Corbell;Joseph J. Lundquist;Eric J. Toone

  • Theory, Spectroscopy, and Crystallographic Analysis of S-Nitrosothiols: Conformational Distribution Dictates Spectroscopic Behavior

    Michael D. Bartberger;K. N. Houk;Steven C. Powell;Joseph D. Mannion

  • Enzyme-catalyzed synthesis of carbohydrates.

    Nathan Wymer;Eric J Toone

Frequent Co-Authors

Jonathan S. Stamler
Jonathan S. Stamler Case Western Reserve University
Robert L. Clark
Robert L. Clark North Carolina State University
Carol A. Fierke
Carol A. Fierke Texas A&M University
James H. Naismith
James H. Naismith Rosalind Franklin Institute
George M. Whitesides
George M. Whitesides Harvard University
Michael D. Bartberger
Michael D. Bartberger Amgen (United States)
Richard S. Stack
Richard S. Stack Duke University
David N. Beratan
David N. Beratan Duke University
Andrew J. Gow
Andrew J. Gow Rutgers, The State University of New Jersey

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