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Michael D. Bartberger

Michael D. Bartberger

D-Index & Metrics

Chemistry

D-Index
43
Citations
8398
World Ranking
17106
National Ranking
4209

Overview

Michael D. Bartberger is affiliated with Amgen in the United States. Their research spans multiple fields with a focus on Chemistry and Biochemistry, Genetics and Molecular Biology. Within these broad areas, their work frequently involves Organic Chemistry, Molecular Biology, Inorganic Chemistry, Materials Chemistry, and Oncology.

The scientist's investigations have concentrated notably on several topics that include Asymmetric Hydrogenation and Catalysis, Asymmetric Synthesis and Catalysis, Advanced Synthetic Organic Chemistry, Biochemical and Molecular Research, Peptidase Inhibition and Analysis, Crystallization and Solubility Studies, and X-ray Diffraction in Crystallography.

Their recent scholarly outputs consist of diverse publications in well-known scientific venues. Selected recent papers include:

  • Systematic Study of the Glutathione Reactivity of N-Phenylacrylamides: 2. Effects of Acrylamide Substitution, 2020, Journal of Medicinal Chemistry
  • Ir-Catalyzed Asymmetric Allylic Alkylation of Dialkyl Malonates Enabling the Construction of Enantioenriched All-Carbon Quaternary Centers, 2022, Journal of the American Chemical Society
  • Iridium-Catalyzed Enantioselective and Diastereoselective Hydrogenation of 1,3-Disubstituted Isoquinolines, 2020, ACS Catalysis
  • Enantioselective total synthesis of (−)-myrifabral A and B, 2020, Chemical Science
  • Enantioselective synthesis of highly oxygenated acyclic quaternary center-containing building blocks via palladium-catalyzed decarboxylative allylic alkylation of cyclic siloxyketones, 2020, Chemical Science

Their frequent publication venues demonstrate a recurring presence in:

  • Cancer Research
  • Chemical Science
  • Journal of the American Chemical Society
  • The Cambridge Structural Database
  • Journal of Medicinal Chemistry

Collaboration forms a significant part of their research activity, often working alongside several coauthors. Frequent collaborators include Brian M. Stoltz, Aurapat Ngamnithiporn, Alexia Kim, Martina S.J. McDermott, and Neil A. O'Brien.

Best Publications

  • A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design

    Brett R. Beno;Kap-Sun Yeung;Michael D. Bartberger;Lewis D. Pennington

  • Anion−Aromatic Bonding: A Case for Anion Recognition by π-Acidic Rings

    Mark Mascal;Alan Armstrong;Michael D. Bartberger

  • The reduction potential of nitric oxide (NO) and its importance to NO biochemistry

    Michael D. Bartberger;Wei Liu;Eleonora Ford;Katrina M. Miranda

  • A Standard Set of Pericyclic Reactions of Hydrocarbons for the Benchmarking of Computational Methods: The Performance of ab Initio, Density Functional, CASSCF, CASPT2, and CBS-QB3 Methods for the Prediction of Activation Barriers, Reaction Energetics, and Transition State Geometries

    Vildan Guner;Kelli S. Khuong;Andrew G. Leach;Patrick S. Lee

  • A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system

    Katrina M. Miranda;Nazareno Paolocci;Tatsuo Katori;Douglas D. Thomas

  • Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development.

    Daqing Sun;Zhihong Li;Yosup Rew;Michael Gribble

  • Insertion of Helium and Molecular Hydrogen Through the Orifice of an Open Fullerene.

    Yves Rubin;Thibaut Jarrosson;Guan-Wu Wang;Michael D. Bartberger

  • The magnitude of [C-H...O] hydrogen bonding in molecular and supramolecular assemblies.

    F. M. Raymo;M. D. Bartberger;K. N. Houk;J. F. Stoddart

  • The physiological chemistry and biological activity of nitroxyl (HNO): the neglected, misunderstood, and enigmatic nitrogen oxide.

    Jon M. Fukuto;Michael D. Bartberger;Andrew S. Dutton;Nazareno Paolocci

  • Structure-based design of novel inhibitors of the MDM2-p53 interaction

    Yosup Rew;Daqing Sun;Felix Gonzalez-Lopez De Turiso;Michael D. Bartberger

  • On the acidity and reactivity of HNO in aqueous solution and biological systems.

    Michael D. Bartberger;Jon M. Fukuto;K. N. Houk

  • Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction.

    John G Allen;Matthew P Bourbeau;G Erich Wohlhieter;Michael D Bartberger

  • Systematic Study of the Glutathione (GSH) Reactivity of N-Arylacrylamides: 1. Effects of Aryl Substitution

    Victor J. Cee;Laurie P. Volak;Yuping Chen;Michael D. Bartberger

  • From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1).

    Yuan Cheng;Ted C. Judd;Michael D. Bartberger;James Brown

  • Photophysics of π-Conjugated Polymers That Incorporate Metal to Ligand Charge Transfer Chromophores

    Kevin D. Ley;C. Ed Whittle;and Michael D. Bartberger;Kirk S. Schanze

  • S-N dissociation energies of S-nitrosothiols: on the origins of nitrosothiol decomposition rates.

    Michael D. Bartberger;Joseph D. Mannion;Steven C. Powell;Jonathan S. Stamler

  • Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins. A chemical discussion of the differential biological effects of these redox related products of NOS.

    Katrina M. Miranda;Raymond W. Nims;Douglas D. Thomas;Michael G. Espey

  • Theory, Spectroscopy, and Crystallographic Analysis of S-Nitrosothiols: Conformational Distribution Dictates Spectroscopic Behavior

    Michael D. Bartberger;K. N. Houk;Steven C. Powell;Joseph D. Mannion

  • Discovery of a Potent, Orally Active 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor for Clinical Study: Identification of (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221)

    Murielle M. Véniant;Clarence Hale;Randall W. Hungate;Kyung Gahm

  • C62, a Non-Classical Fullerene Incorporating a Four-Membered Ring

    Wenyuan Qian;Michael D. Bartberger;Salvador J. Pastor;Kendall N. Houk

Frequent Co-Authors

Mark H. Norman
Mark H. Norman Amgen (Canada)
Kendall N. Houk
Kendall N. Houk University of California, Los Angeles
Stephen J. Wood
Stephen J. Wood University of Melbourne
Brian M. Stoltz
Brian M. Stoltz California Institute of Technology
William R. Dolbier
William R. Dolbier University of Florida
Jon M. Fukuto
Jon M. Fukuto Sonoma State University

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