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Christophe L. M. J. Verlinde

Christophe L. M. J. Verlinde

D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
9316
World Ranking
15210
National Ranking
6359

Overview

Christophe L. M. J. Verlinde is affiliated with the University of Washington in the United States. Their research primarily focuses on the fields of Medicine and Immunology and Microbiology, with particular attention to parasitology, infectious diseases, molecular biology, epidemiology, and organic chemistry as subfields of study.

The scientist's work spans a variety of topics, including parasitic infections and diagnostics, Pneumocystis jirovecii pneumonia detection and treatment, Clostridium difficile and Clostridium perfringens research, viral gastroenteritis research and epidemiology, RNA and protein synthesis mechanisms, biochemical and molecular research, and the synthesis and biological evaluation of compounds.

Verlinde has authored several recent research papers, among them:

  • Spontaneous Selection of Cryptosporidium Drug Resistance in a Calf Model of Infection, 2021, published in Antimicrobial Agents and Chemotherapy
  • Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei, 2020, published in RSC Medicinal Chemistry
  • Repurposing Infectious Disease Hits as Anti-Cryptosporidium Leads, 2021, published in ACS Infectious Diseases
  • Spontaneous selection of Cryptosporidium drug resistance in a calf model of infection, 2021, published in bioRxiv (Cold Spring Harbor Laboratory)
  • Towards a primary care based COVID-19 adult vaccination strategy in Flanders, 2025, published in International Journal of Integrated Care

Their collaborative work includes frequent co-authorship with researchers such as Robert K. M. Choy, J. Robert Gillespie, Aisha Mushtaq, Ranae M. Ranade, and Zhongsheng Zhang.

Verlinde's publications have appeared in a range of scientific venues, including:

  • Antimicrobial Agents and Chemotherapy
  • RSC Medicinal Chemistry
  • ACS Infectious Diseases
  • bioRxiv (Cold Spring Harbor Laboratory)
  • International Journal of Integrated Care

Best Publications

  • Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase.

    F S Buckner;C L Verlinde;A C La Flamme;W C Van Voorhis

  • Structure-based drug design: progress, results and challenges

    Christophe Lmj Verlinde;Wim Gj Hol

  • Genomic-scale prioritization of drug targets: the TDR Targets database

    Fernán Agüero;Bissan Al-Lazikani;Martin Aslett;Matthew Berriman

  • Glycolysis as a target for the design of new anti-trypanosome drugs

    Christophe L.M.J. Verlinde;Véronique Hannaert;Casimir Blonski;Michèle Willson

  • Five Members of a Novel Ca2+-binding Protein (CABP) Subfamily with Similarity to Calmodulin

    Françoise Haeseleer;Izabela Sokal;Christophe L. M. J. Verlinde;Hediye Erdjument-Bromage

  • Missense Mutations in the Regulatory Domain of PKCγ: A New Mechanism for Dominant Nonepisodic Cerebellar Ataxia

    Dong Hui Chen;Zoran Brkanac;Christophe L M J Verlinde;Xiao Jian Tan

  • Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors.

    Kayode K Ojo;Eric T Larson;Katelyn R Keyloun;Lisa J Castaneda

  • Rational Modification of a Candidate Cancer Drug for Use Against Chagas Disease

    James M. Kraus;Christophe L. M. J. Verlinde;Mandana Karimi;Galina I. Lepesheva

  • Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase

    A. M. Aronov;S. Suresh;F. S. Buckner;W. C. Van Voorhis

  • AB5 toxins: structures and inhibitor design

    Erkang Fan;Ethan A Merritt;Christophe Lmj Verlinde;Wim Gj Hol

  • Solution and crystallographic studies of branched multivalent ligands that inhibit the receptor-binding of cholera toxin.

    Zhongsheng Zhang;Ethan A. Merritt;Misol Ahn;Claudia Roach

  • Alternatively spliced isoforms of the human constitutive androstane receptor.

    Scott S. Auerbach;Richard Ramsden;Matthew A. Stoner;Christophe Verlinde

  • Three-dimensional structure of the diphtheria toxin repressor in complex with divalent cation co-repressors

    Xiayang Qiu;Christophe Lmj Verlinde;Suping Zhang;Michael P Schmitt

  • Crystal structure of glycosomal glyceraldehyde-3-phosphate dehydrogenase from Leishmania mexicana: implications for structure-based drug design and a new position for the inorganic phosphate binding site

    Hidong Kim;Ingeborg K. Feil;Christophe L. M. J. Verlinde;Philip H. Petra

  • Discovery of Potent and Selective Inhibitors of CDPK1 from C. parvum and T. gondii

    Ryan C. Murphy;Kayode K. Ojo;Eric T. Larson;Alejandro Castellanos-Gonzalez

  • Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design.

    Jerome C. Bressi;Christophe L. M. J. Verlinde;Alex M. Aronov;My Le Shaw

  • Structure-based exploration of the ganglioside GM1 binding sites of Escherichia coli heat-labile enterotoxin and cholera toxin for the discovery of receptor antagonists.

    Wendy E. Minke;Claudia Roach;Wim G. J. Hol;Christophe L. M. J. Verlinde

  • Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery.

    James M. Kraus;Hari Babu Tatipaka;Sarah A. McGuffin;Naveen Kumar Chennamaneni

  • Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: elucidation of a novel binding mode for a 2-amino-N(6)-substituted adenosine.

    Jerome C. Bressi;Jungwoo Choe;Melinda T. Hough;Frederick S. Buckner

  • Structure of glycosomal glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma brucei determined from Laue data.

    Fred M. D. Vellieux;Janos Hajdu;Christophe L. M. J. Verlinde;Hillie Groendijk

Frequent Co-Authors

Wim G. J. Hol
Wim G. J. Hol University of Washington
Frederick S. Buckner
Frederick S. Buckner University of Washington
Wesley C. Van Voorhis
Wesley C. Van Voorhis University of Washington
Ethan A. Merritt
Ethan A. Merritt University of Washington
Michael H. Gelb
Michael H. Gelb University of Washington
Krzysztof Palczewski
Krzysztof Palczewski University of California, Irvine
Kor H. Kalk
Kor H. Kalk University of Groningen
Fred R. Opperdoes
Fred R. Opperdoes Université Catholique de Louvain
Paul A. M. Michels
Paul A. M. Michels University of Edinburgh

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