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Molecular Biology

D-Index
74
Citations
16180
World Ranking
1245
National Ranking
640

Overview

André Lieber is affiliated with the University of Washington in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with notable work in several subfields including Molecular Biology, Genetics, Oncology, Infectious Diseases, and Immunology.

Their work addresses core topics such as virus-based gene therapy research, CRISPR and genetic engineering, RNA interference and gene delivery, CAR-T cell therapy research, hemoglobinopathies and related disorders, HIV research and treatment, and prenatal screening and diagnostics.

Frequent coauthors collaborating with André Lieber include Sucheol Gil, Hans-Peter Kiem, Hongjie Wang, Aphrodite Georgakopoulou, and Chang Li.

The scientist's publication record shows a concentration of articles in several key venues with repeated contributions, including Blood, Molecular Therapy - Methods & Clinical Development, Molecular Therapy, Blood Advances, and JCI Insight.

Representative recent papers authored or coauthored by André Lieber include:

  • In vivo HSPC gene therapy with base editors allows for efficient reactivation of fetal γ-globin in β-YAC mice, 2021, Blood Advances
  • In vivo HSC prime editing rescues Sickle Cell Disease in a mouse model, 2023, Blood
  • In Vivo HSC Gene Therapy Using a Bi-modular HDAd5/35++ Vector Cures Sickle Cell Disease in a Mouse Model, 2020, Molecular Therapy
  • Safe and efficient in vivo hematopoietic stem cell transduction in nonhuman primates using HDAd5/35++ vectors, 2021, Molecular Therapy - Methods & Clinical Development
  • Enhanced HbF reactivation by multiplex mutagenesis of thalassemic CD34+ cells in vitro and in vivo, 2021, Blood

Best Publications

  • CD46 is a cellular receptor for group B adenoviruses

    Anuj Gaggar;Dmitry M Shayakhmetov;André Lieber

  • The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors.

    Andre Lieber;Cheng Yi He;Leonard Meuse;David Schowalter

  • Adenovirus Binding to Blood Factors Results in Liver Cell Infection and Hepatotoxicity

    Dmitry M. Shayakhmetov;Anuj Gaggar;Shaoheng Ni;Zong Yi Li

  • Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14

    Hongjie Wang;Hongjie Wang;Zong Yi Li;Ying Liu;Jonas Persson

  • Efficient Gene Transfer into Human CD34+ Cells by a Retargeted Adenovirus Vector

    Dmitry M. Shayakhmetov;Thalia Papayannopoulou;George Stamatoyannopoulos;André Lieber

  • Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes

    Alan L. Parker;Simon N. Waddington;Campbell G. Nicol;Dmitry M. Shayakhmetov

  • Targeted delivery of proapoptotic peptides to tumor-associated macrophages improves survival

    Maryelise Cieslewicz;Jingjing Tang;Jonathan L. Yu;Hua Cao

  • Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo.

    André Lieber;Cheng Yi He;Irina Kirillova;Mark A. Kay

  • Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: comparisons between immunocompetent and immunodeficient inbred strains.

    D Barr;J Tubb;D Ferguson;A Scaria

  • Analysis of Adenovirus Sequestration in the Liver, Transduction of Hepatic Cells, and Innate Toxicity after Injection of Fiber-Modified Vectors

    Dmitry M. Shayakhmetov;Zong Yi Li;Shaoheng Ni;André Lieber

  • Analysis of Epithelial and Mesenchymal Markers in Ovarian Cancer Reveals Phenotypic Heterogeneity and Plasticity

    Robert Strauss;Zong-Yi Li;Ying Liu;Ines Beyer

  • Dependence of Adenovirus Infectivity on Length of the Fiber Shaft Domain

    Dmitry M. Shayakhmetov;André Lieber

  • Cutting Edge: Mechanical Forces Acting on T Cells Immobilized via the TCR Complex Can Trigger TCR Signaling

    Ya-Chen Li;Bing-Mae Chen;Pei-Chun Wu;Tian-Lu Cheng

  • SELECTION OF EFFICIENT CLEAVAGE SITES IN TARGET RNAS BY USING A RIBOZYME EXPRESSION LIBRARY

    Andre Lieber;Michael Strauss

  • Discovery of Novel Methylation Biomarkers in Cervical Carcinoma by Global Demethylation and Microarray Analysis

    Pavel Sova;Qinghua Feng;Gary Geiss;Troy Wood

  • Directed evolution generates a novel oncolytic virus for the treatment of colon cancer.

    Irene Kuhn;Paul Harden;Maxine Bauzon;Cecile Chartier

  • Insulation from viral transcriptional regulatory elements improves inducible transgene expression from adenovirus vectors in vitro and in vivo.

    D S Steinwaerder;A Lieber

  • Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1

    Adel Benlahrech;Julian Harris;Andrea Meiser;Timos Papagatsias

  • Adenovirus-platelet interaction in blood causes virus sequestration to the reticuloendothelial system of the liver.

    Daniel Stone;Ying Liu;Dmitry Shayakhmetov;Zong Yi Li

  • A new group B adenovirus receptor is expressed at high levels on human stem and tumor cells.

    Sebastian Tuve;Hongjie Wang;Carol Ware;Ying Liu

Frequent Co-Authors

Thalia Papayannopoulou
Thalia Papayannopoulou University of Washington
Mark A. Kay
Mark A. Kay Stanford University
Hans Peter Kiem
Hans Peter Kiem Fred Hutchinson Cancer Research Center
Akseli Hemminki
Akseli Hemminki University of Helsinki
Nancy B. Kiviat
Nancy B. Kiviat University of Washington
Zsuzsanna Izsvák
Zsuzsanna Izsvák Max Delbrück Center for Molecular Medicine
Nicole Urban
Nicole Urban Fred Hutchinson Cancer Research Center
Michael A. Strauss
Michael A. Strauss University of Oklahoma
Jiri Bartek
Jiri Bartek Karolinska Institute
Tanja D. de Gruijl
Tanja D. de Gruijl Vrije Universiteit Amsterdam

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