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Daan M. F. van Aalten

Daan M. F. van Aalten

D-Index & Metrics

Biology and Biochemistry

D-Index
79
Citations
25497
World Ranking
4264
National Ranking
320

Overview

Daan M. F. van Aalten is affiliated with the University of Dundee in the United Kingdom. Their research encompasses fields primarily in Biochemistry, Genetics and Molecular Biology, as well as Chemistry. More specifically, their subfields of study include Molecular Biology, Organic Chemistry, Immunology, Physiology, and Plant Science.

The main topics addressed in van Aalten's work focus on:

  • Glycosylation and Glycoproteins Research
  • Carbohydrate Chemistry and Synthesis
  • Galectins and Cancer Biology
  • Lysosomal Storage Disorders Research
  • Chromosomal and Genetic Variations
  • Biochemical and Molecular Research
  • Antifungal resistance and susceptibility

Van Aalten has contributed to numerous scientific papers. Selected recent publications include:

  • "An intellectual disability syndrome with single-nucleotide variants in O-GlcNAc transferase", 2020, European Journal of Human Genetics
  • "Loss of O-GlcNAcase catalytic activity leads to defects in mouse embryogenesis", 2021, Journal of Biological Chemistry
  • "Tools for functional dissection of site-specific O-GlcNAcylation", 2020, RSC Chemical Biology
  • "O-GlcNAcase contributes to cognitive function in Drosophila", 2020, Journal of Biological Chemistry
  • "A mechanism-inspired UDP- N -acetylglucosamine pyrophosphorylase inhibitor", 2020, RSC Chemical Biology

Frequent coauthors in van Aalten's publications include Andrew T. Ferenbach, Ignacy Czajewski, Olawale G. Raimi, Florence Authier, and Sergio G. Bartual.

Van Aalten's work is regularly published in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Biological Chemistry
  • RSC Chemical Biology
  • Disease Models & Mechanisms
  • Nature Communications

Best Publications

  • PRODRG: a tool for high-throughput crystallography of protein–ligand complexes

    Alexander W. Schüttelkopf;Daan M. F. van Aalten

  • PDK1, the master regulator of AGC kinase signal transduction.

    Alfonso Mora;David Komander;Daan M.F. van Aalten;Dario R. Alessi

  • The Non-catalytic Chitin-binding Protein CBP21 from Serratia marcescens Is Essential for Chitin Degradation

    Gustav Vaaje-Kolstad;Svein J. Horn;Daan M.F. van Aalten;Bjørnar Synstad

  • High-Resolution Structure of the Pleckstrin Homology Domain of Protein Kinase B/Akt Bound to Phosphatidylinositol (3,4,5)-Trisphosphate

    Christine C Thomas;Maria Deak;Dario R Alessi;Daan M.F van Aalten

  • Structure of the Lkb1-Strad-Mo25 Complex Reveals an Allosteric Mechanism of Kinase Activation.

    Elton Zeqiraj;Beatrice Maria Filippi;Maria Deak;Dario R. Alessi

  • Crystal structure and binding properties of the Serratia marcescens chitin-binding protein CBP21

    Gustav Vaaje-Kolstad;Douglas R. Houston;Anna H.K. Riemen;Vincent G.H. Eijsink

  • Binding of Phosphatidylinositol 3,4,5-Trisphosphate to the Pleckstrin Homology Domain of Protein Kinase B Induces a Conformational Change

    Christine C Milburn;Maria Deak;Sharon M Kelly;Nick C Price

  • N-Myristoyltransferase Inhibitors as New Leads to Treat Sleeping Sickness.

    Julie A. Frearson;Stephen Brand;Stuart P. McElroy;Laura A.T. Cleghorn

  • BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm

    Laura Hobley;Adam Ostrowski;Francesco V. Rao;Keith M. Bromley

  • Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

    Mahima Swamy;Shalini Pathak;Katarzyna M Grzes;Sebastian Damerow

  • Structure of human chitotriosidase. Implications for specific inhibitor design and function of mammalian chitinase-like lectins.

    Fabrizia Fusetti;Holger von Moeller;Douglas Houston;Henriëtte J. Rozeboom

  • Structure and metal-dependent mechanism of peptidoglycan deacetylase, a streptococcal virulence factor

    David E. Blair;Alexander W. Schüttelkopf;James I. MacRae;Daan M. F. van Aalten

  • High Resolution Crystal Structure of the Human Pdk1 Catalytic Domain Defines the Regulatory Phosphopeptide Docking Site

    Ricardo M. Biondi;David Komander;Christine C. Thomas;Jose M. Lizcano

  • Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis

    Francesco V Rao;Helge C Dorfmueller;Fabrizio Villa;Matthew Allwood

  • Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation

    Agne Kazlauskaite;R. Julio Martinez-Torres;Scott Wilkie;Atul Kumar

  • Mutational and computational analysis of the role of conserved residues in the active site of a family 18 chitinase.

    Bjørnar Synstad;Sigrid Gåseidnes;Daan M. F. van Aalten;Gert Vriend

  • Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity

    Kuan-Chuan Pao;Nicola T. Wood;Axel Knebel;Karim Rafie

  • Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates

    David Komander;Alison Fairservice;Maria Deak;Gursant S Kular

  • Structure and mechanism of chitin deacetylase from the fungal pathogen Colletotrichum lindemuthianum.

    David E. Blair;Omid Hekmat;Alexander W. Schüttelkopf;Binesh Shrestha

  • Analysis of the LKB1-STRAD-MO25 Complex

    Jérôme Boudeau;John W. Scott;Nicoletta Resta;Maria Deak

Frequent Co-Authors

Dario R. Alessi
Dario R. Alessi University of Dundee
Maria Deak
Maria Deak University of Dundee
David Komander
David Komander Walter and Eliza Hall Institute of Medical Research
Vincent G. H. Eijsink
Vincent G. H. Eijsink Norwegian University of Life Sciences
Michael A. J. Ferguson
Michael A. J. Ferguson University of Dundee
Wim Crielaard
Wim Crielaard Academic Center for Dentistry Amsterdam
Alan R. Prescott
Alan R. Prescott University of Dundee
Gustav Vaaje-Kolstad
Gustav Vaaje-Kolstad Norwegian University of Life Sciences
Mark Peggie
Mark Peggie University of Dundee
Paul R. Crocker
Paul R. Crocker University of Dundee

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