His primary scientific interests are in Biochemistry, Protein structure, Cell biology, Kinase and Phosphorylation. His study involves Enzyme, Hydrolase, Binding site, Transferase and Serratia marcescens, a branch of Biochemistry. His Enzyme study integrates concerns from other disciplines, such as Chitin deacetylase and Peptide sequence.
Daan M. F. van Aalten has included themes like Hydrophobin, Plasma protein binding and Scaffold protein in his Protein structure study. His research in the fields of Protein kinase A overlaps with other disciplines such as PINK1. Daan M. F. van Aalten interconnects Signal transduction and Ubiquitin ligase in the investigation of issues within Phosphorylation.
His scientific interests lie mostly in Biochemistry, Enzyme, Transferase, Stereochemistry and Protein structure. In his research, Cell wall is intimately related to Aspergillus fumigatus, which falls under the overarching field of Biochemistry. His Enzyme research includes themes of Antifungal drug and Saccharomyces cerevisiae, Yeast.
His Transferase research is multidisciplinary, incorporating elements of Genetics, Glycosylation, Serine, Tetratricopeptide and Cell biology. His work deals with themes such as Cyclic peptide, Peptide, Substrate and Residue, which intersect with Stereochemistry. His Protein structure study which covers Plasma protein binding that intersects with Protein phosphorylation.
His primary areas of study are Biochemistry, Transferase, Enzyme, Cell biology and Glycosylation. He frequently studies issues relating to Aspergillus fumigatus and Biochemistry. His Transferase research integrates issues from Genetics, Intellectual disability, Serine, Tetratricopeptide and Glycosyltransferase.
His Enzyme research incorporates themes from Protein structure, Aspartic acid, Antifungal drug and Mutagenesis. He has researched Cell biology in several fields, including Phenotype, Drosophila melanogaster, Glutamine and Point mutation. His research integrates issues of Acceptor, Biophysics, Proteolysis, Stereochemistry and Substrate in his study of Glycosylation.
Daan M. F. van Aalten mainly investigates Biochemistry, Transferase, Serine, Gene and Cell biology. His work in IL-2 receptor, Uridine diphosphate N-acetylglucosamine, CD28, Glutamine transport and ZAP70 are all subfields of Biochemistry research. His study on Transferase is covered under Enzyme.
In his study, Peptide, Thio-, Glycosyltransferase and HeLa is inextricably linked to Cysteine, which falls within the broad field of Serine. His work on Mutation as part of his general Gene study is frequently connected to Parkinson's disease and In patient, thereby bridging the divide between different branches of science. His Cell biology research includes elements of Model organism, Hox gene, Drosophila melanogaster and Mutant, Homeotic gene.
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PDK1, the master regulator of AGC kinase signal transduction.
Alfonso Mora;David Komander;Daan M.F. van Aalten;Dario R. Alessi.
Seminars in Cell & Developmental Biology (2004)
The Non-catalytic Chitin-binding Protein CBP21 from Serratia marcescens Is Essential for Chitin Degradation
Gustav Vaaje-Kolstad;Svein J. Horn;Daan M.F. van Aalten;Bjørnar Synstad.
Journal of Biological Chemistry (2005)
High-Resolution Structure of the Pleckstrin Homology Domain of Protein Kinase B/Akt Bound to Phosphatidylinositol (3,4,5)-Trisphosphate
Christine C Thomas;Maria Deak;Dario R Alessi;Daan M.F van Aalten.
Current Biology (2002)
Binding of Phosphatidylinositol 3,4,5-Trisphosphate to the Pleckstrin Homology Domain of Protein Kinase B Induces a Conformational Change
Christine C Milburn;Maria Deak;Sharon M Kelly;Nick C Price.
Biochemical Journal (2003)
Structure of the Lkb1-Strad-Mo25 Complex Reveals an Allosteric Mechanism of Kinase Activation.
Elton Zeqiraj;Beatrice Maria Filippi;Maria Deak;Dario R. Alessi.
Crystal structure and binding properties of the Serratia marcescens chitin-binding protein CBP21
Gustav Vaaje-Kolstad;Douglas R. Houston;Anna H.K. Riemen;Vincent G.H. Eijsink.
Journal of Biological Chemistry (2005)
Structure of human chitotriosidase. Implications for specific inhibitor design and function of mammalian chitinase-like lectins.
Fabrizia Fusetti;Holger von Moeller;Douglas Houston;Henriëtte J. Rozeboom.
Journal of Biological Chemistry (2002)
N-Myristoyltransferase Inhibitors as New Leads to Treat Sleeping Sickness.
Julie A. Frearson;Stephen Brand;Stuart P. McElroy;Laura A.T. Cleghorn.
Structure and metal-dependent mechanism of peptidoglycan deacetylase, a streptococcal virulence factor
David E. Blair;Alexander W. Schüttelkopf;James I. MacRae;Daan M. F. van Aalten.
Proceedings of the National Academy of Sciences of the United States of America (2005)
BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm
Laura Hobley;Adam Ostrowski;Francesco V. Rao;Keith M. Bromley.
Proceedings of the National Academy of Sciences of the United States of America (2013)
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