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Biology and Biochemistry

D-Index
58
Citations
11574
World Ranking
13225
National Ranking
940

Overview

Dieter Niederacher is affiliated with Heinrich Heine University Düsseldorf in Germany. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a particular focus on Oncology, Molecular Biology, Cancer Research, Genetics, and Pulmonary and Respiratory Medicine.

Their scholarly output highlights key topics including:

  • Cancer Genomics and Diagnostics
  • Cancer Cells and Metastasis
  • BRCA gene mutations in cancer
  • Advanced Breast Cancer Therapies
  • Estrogen and related hormone effects
  • Genetic factors in colorectal cancer
  • Single-cell and spatial transcriptomics

Notable recent papers by Niederacher and collaborators include:

  • Ovarian and Breast Cancer Risks Associated With Pathogenic Variants in RAD51C and RAD51D, 2020, published in JNCI Journal of the National Cancer Institute
  • Efficacy of Lapatinib in Patients with HER2-Negative Metastatic Breast Cancer and HER2-Positive Circulating Tumor Cells-The DETECT III Clinical Trial, 2024, Clinical Chemistry
  • Progesterone receptor membrane component 1 regulates lipid homeostasis and drives oncogenic signaling resulting in breast cancer progression, 2020, Breast Cancer Research
  • Ultra-sensitive CTC-based liquid biopsy for pancreatic cancer enabled by large blood volume analysis, 2023, Molecular Cancer
  • Comparative analysis of EpCAM high-expressing and low-expressing circulating tumour cells with regard to their clonal relationship and clinical value, 2023, British Journal of Cancer

Their frequent co-authors include:

  • Tanja Fehm
  • Hans Neubauer
  • André Franken
  • Mahdi Rivandi
  • Liwen Yang

Common venues for Niederacher's publications are:

  • Senologie - Zeitschrift für Mammadiagnostik und -therapie
  • Geburtshilfe und Frauenheilkunde
  • Cancers
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research

Best Publications

  • Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene

    Alfons Meindl;Heide Hellebrand;Constanze Wiek;Verena Erven

  • Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).

    Nasim Mavaddat;Daniel Barrowdale;Irene L. Andrulis;Susan M. Domchek

  • The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer.

    Magali Olivier;Anita Langerød;Patrizia Carrieri;Jonas Bergh

  • Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

    Stig E. Bojesen;Stig E. Bojesen;Karen A. Pooley;Sharon E. Johnatty;Jonathan Beesley

  • Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.

    Timothy R. Rebbeck;Nandita Mitra;Fei Wan;Olga M. Sinilnikova

  • Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

    Catherine M Phelan;Karoline B Kuchenbaecker;Karoline B Kuchenbaecker;Jonathan P Tyrer;Siddhartha P Kar

  • A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population

    Antonis C. Antoniou;Xianshu Wang;Zachary S. Fredericksen;Lesley McGuffog

  • Multistep carcinogenesis of breast cancer and tumour heterogeneity.

    M. W. Beckmann;Dieter Niederacher;Hans-Georg Schnürch;Barry A. Gusterson

  • Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.

    Roger L Milne;Roger L Milne;Karoline B Kuchenbaecker;Karoline B Kuchenbaecker;Kyriaki Michailidou;Kyriaki Michailidou;Jonathan Beesley

  • Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers

    Antonis C. Antoniou;Antonis C. Antoniou;Amanda B. Spurdle;Amanda B. Spurdle;Olga M. Sinilnikova;Olga M. Sinilnikova;Sue Healey;Sue Healey

  • Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk

    Fergus J. Couch;Xianshu Wang;Lesley McGuffog;Andrew Lee

  • Evaluation of polygenic risk scores for breast and ovarian cancer risk prediction in BRCA1 and BRCA2 mutation carriers

    Karoline B Kuchenbaecker;Karoline B Kuchenbaecker;Lesley McGuffog;Daniel Barrowdale;Andrew Lee

  • RAD51 135G→C Modifies Breast Cancer Risk among BRCA2 Mutation Carriers: Results from a Combined Analysis of 19 Studies

    Antonis C. Antoniou;Olga M. Sinilnikova;Jacques Simard;Mélanie Léoné

  • Aberrant methylation of the Wnt antagonist SFRP1 in breast cancer is associated with unfavourable prognosis

    J Veeck;D Niederacher;H An;H An;E Klopocki

  • Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations

    Timothy R. Rebbeck;Tara M. Friebel;Eitan Friedman;Ute Hamann

  • Diagnostic leukapheresis enables reliable detection of circulating tumor cells of nonmetastatic cancer patients

    Johannes C. Fischer;Dieter Niederacher;Stefan A. Topp;Ellen Honisch

  • Common Breast Cancer Susceptibility Alleles and the Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Implications for Risk Prediction

    Antonis C. Antoniou;Jonathan Beesley;Lesley McGuffog;Olga M. Sinilnikova

  • Prevalence of BRCA1/2 germline mutations in 21 401 families with breast and ovarian cancer

    Karin Kast;Karin Kast;Kerstin Rhiem;Barbara Wappenschmidt;Eric Hahnen

  • Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as low-penetrance alleles in German and Italian familial breast cancer cases

    Irene Catucci;Rongxi Yang;Rongxi Yang;Paolo Verderio;Sara Pizzamiglio

  • Role of DNA methylation in miR-200c/141 cluster silencing in invasive breast cancer cells

    Rui Neves;Christina Scheel;Sandra Weinhold;Ellen Honisch

Frequent Co-Authors

Tanja Fehm
Tanja Fehm Heinrich Heine University Düsseldorf
Rita K. Schmutzler
Rita K. Schmutzler University of Cologne
Alfons Meindl
Alfons Meindl Technical University of Munich
Christoph Engel
Christoph Engel Leipzig University
Barbara Wappenschmidt
Barbara Wappenschmidt University of Cologne
Irene L. Andrulis
Irene L. Andrulis University of Toronto
Heli Nevanlinna
Heli Nevanlinna University of Helsinki
Georgia Chenevix-Trench
Georgia Chenevix-Trench QIMR Berghofer Medical Research Institute
Fergus J. Couch
Fergus J. Couch Mayo Clinic

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