World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
44
Citations
8928
World Ranking
2913
National Ranking
1389

Overview

Andrew J. Holland is affiliated with Johns Hopkins University School of Medicine in the United States. Their research primarily falls within the domain of Biochemistry, Genetics and Molecular Biology, with a specific focus on Molecular Biology, Cell Biology, Genetics, Plant Science, and Oncology.

The scientist's work covers various main topics, which include:

  • Microtubule and mitosis dynamics
  • Ubiquitin and proteasome pathways
  • Genetic and Kidney Cyst Diseases
  • DNA Repair Mechanisms
  • Cancer-related Molecular Pathways
  • Protist diversity and phylogeny
  • Genomics and Chromatin Dynamics

Andrew J. Holland has contributed numerous publications in notable scientific venues. Frequent journals include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Genes & Development
  • The Journal of Cell Biology
  • Nature Structural & Molecular Biology
  • The EMBO Journal

Recent papers authored or co-authored by the scientist demonstrate a focus on cellular mechanisms related to centrosome function, genetic regulation, and molecular pathways influencing cell biology:

  • "Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication," 2020, Nature Structural & Molecular Biology
  • "Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer," 2020, Nature
  • "Time is of the essence: the molecular mechanisms of primary microcephaly," 2021, Genes & Development
  • "ANKRD26 recruits PIDD1 to centriolar distal appendages to activate the PIDDosome following centrosome amplification," 2020, The EMBO Journal
  • "Centrosome defects cause microcephaly by activating the 53BP1-USP28-TP53 mitotic surveillance pathway," 2020, The EMBO Journal

Collaborative work is a significant aspect of their research output with frequent co-authors including Colin R. Gliech, Cayla E Jewett, Margaret A. Strong, Phillip M. Scott, and Gina M LoMastro.

Best Publications

  • Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

    Andrew J. Holland;Don W. Cleveland

  • Once and only once: mechanisms of centriole duplication and their deregulation in disease

    Erich A. Nigg;Andrew J. Holland

  • Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals

    Michelle S. Levine;Bjorn Bakker;Bram Boeckx;Julia Moyett

  • Losing balance: the origin and impact of aneuploidy in cancer

    Andrew J Holland;Don W Cleveland

  • Inducible, reversible system for the rapid and complete degradation of proteins in mammalian cells

    Andrew J. Holland;Daniele Fachinetti;Daniele Fachinetti;Joo Seok Han;Joo Seok Han;Don W. Cleveland;Don W. Cleveland

  • Cep152 interacts with Plk4 and is required for centriole duplication

    Emily M. Hatch;Anita Kulukian;Andrew J. Holland;Don W. Cleveland

  • Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability

    Andrew J. Holland;Weijie Lan;Sherry Niessen;Heather Hoover

  • Aurora Kinases and Protein Phosphatase 1 Mediate Chromosome Congression through Regulation of CENP-E

    Yumi Kim;Andrew J. Holland;Weijie Lan;Don W. Cleveland;Don W. Cleveland

  • Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements

    Andrew J Holland;Don W Cleveland

  • A two-step mechanism for epigenetic specification of centromere identity and function

    Daniele Fachinetti;H. Diego Folco;H. Diego Folco;Yael Nechemia-Arbely;Luis P. Valente

  • Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors

    Alain D. Silk;Lauren M. Zasadil;Andrew J. Holland;Andrew J. Holland;Benjamin Vitre;Benjamin Vitre

  • Mechanism and Regulation of Centriole and Cilium Biogenesis.

    David K. Breslow;Andrew J. Holland

  • The impact of mitotic errors on cell proliferation and tumorigenesis.

    Michelle S. Levine;Andrew J. Holland

  • Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells

    Reto Gassmann;Andrew J. Holland;Dileep Varma;Xiaohu Wan

  • A USP28-53BP1-p53-p21 signaling axis arrests growth after centrosome loss or prolonged mitosis.

    Bramwell G. Lambrus;Vikas Daggubati;Yumi Uetake;Phillip M. Scott

  • Binding of STIL to Plk4 activates kinase activity to promote centriole assembly.

    Tyler C. Moyer;Kevin M. Clutario;Bramwell G. Lambrus;Vikas Daggubati

  • The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation.

    Stephen S Taylor;Maria I F Scott;Andrew J Holland

  • The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle

    Andrew J. Holland;Daniele Fachinetti;Quan Zhu;Manuel Bauer

  • Requirements for NuMA in maintenance and establishment of mammalian spindle poles.

    Alain D. Silk;Andrew J. Holland;Don W. Cleveland

  • p53 protects against genome instability following centriole duplication failure

    Bramwell G. Lambrus;Yumi Uetake;Kevin M. Clutario;Vikas Daggubati

Frequent Co-Authors

Don W. Cleveland
Don W. Cleveland University of California, San Diego
Stephen S. Taylor
Stephen S. Taylor University of Manchester
Arshad Desai
Arshad Desai University of California, San Diego
Elaine Fuchs
Elaine Fuchs Rockefeller University
Inder M. Verma
Inder M. Verma Salk Institute for Biological Studies
Sherry Niessen
Sherry Niessen Pfizer (United States)
Scott A. Gerber
Scott A. Gerber Dartmouth College
Denis Wirtz
Denis Wirtz Johns Hopkins University
Erich A. Nigg
Erich A. Nigg University of Basel
Kun-Liang Guan
Kun-Liang Guan Westlake University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Molecular Biology opens doors to a variety of related online degrees and career paths. If you are interested in expanding your knowledge beyond pure molecular sciences, there are numerous flexible online programs to consider.

For those curious about the historical context of scientific developments, pursuing an online history master's degree can provide valuable perspective and research skills. Alternatively, understanding how scientific materials and resources are organized can be achieved through investigating what schools offer library science degrees fully online.

If you want to apply your scientific background directly to healthcare, look at accredited speech pathology programs that are available online and meet rigorous industry standards. Plus, if you have a non-health science undergraduate degree, you can bridge your qualifications through speech pathology bridge programs online.

These diverse programs can complement a background in Molecular Biology, enhancing your career versatility in science, healthcare, education, and research sectors.

Best Scientists Citing Andrew J. Holland

Trending Scientists